Development of an Integrated Continuous Crystallization Process of Vitamin D3

2016 ◽  
Vol 88 (9) ◽  
pp. 1213-1213 ◽  
Author(s):  
M. Escriba-Gelonch ◽  
V. Hessel ◽  
T. Noël ◽  
M. C. Maier ◽  
H. Gruber-Wölfler
Keyword(s):  
Vitamin D3 ◽  
Crystallization Process ◽  
Continuous Crystallization

scholarly journals Linear Analysis of a Continuous Crystallization Process for Enantiomer Separation

Processes ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 1337
Author(s):  
Michael Mangold ◽  
Nadiia Huskova ◽  
Jonathan Gänsch ◽  
Andreas Seidel-Morgenstern
Keyword(s):  
Analytical Solution ◽  
Linear Model ◽  
Process Design ◽  
Crystallization Process ◽  
Enantiomer Separation ◽  
Computational Domain ◽  
Process Dynamics ◽  
Continuous Crystallization ◽  
Operation Conditions ◽  
Insight Into

Continuous preferential crystallization is an innovative approach to the separation of chiral substances. The process considered in this work takes place in a gently agitated fluidized bed located in a tubular crystallizer. The feasibility of the process has been shown in previous work, but it also turned out that choosing suitable operation conditions is quite delicate. Hence, a model based process design is desirable. Existing models of the process are rather complicated and require long computational times. In this work, a simple linear dynamic model is suggested, which captures the main properties of the process. The model is distributed in space and in a property coordinate. Using the method of characteristics, a semi-analytical solution of the linear model is derived. As a challenge to the solution, there is a recycle loop in the process that causes a feedback and couples the boundary conditions at different boundaries of the computational domain. In order to deal with this, a numerical scheme is suggested. The semi-analytical solution provides a deeper insight into the process dynamics. A comparison with a more detailed mathematical model of the process and with experiments shows strengths and limitations of the linear model.

Closed-loop identification of a continuous crystallization process

AIChE Journal ◽  
1996 ◽  
Vol 42 (3) ◽  
pp. 767-776 ◽  
Author(s):  
R. A. Eek ◽  
J. A. Both ◽  
P. M. J. Van den Hof
Keyword(s):  
Closed Loop ◽  
Crystallization Process ◽  
Continuous Crystallization ◽  
Closed Loop Identification
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