High-Throughput Screening Technology for Automotive Applications

2014 ◽  
Vol 86 (11) ◽  
pp. 1941-1947 ◽  
Author(s):  
Andreas Sundermann ◽  
Olga Gerlach
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Automotive Applications ◽  
Screening Technology

scholarly journals Phytochemicals potently inhibit migration of metastatic breast cancer cells

2015 ◽  
Vol 7 (7) ◽  
pp. 792-800 ◽  
Author(s):  
Stephanie Lemmo Ham ◽  
Samila Nasrollahi ◽  
Kush N. Shah ◽  
Andrew Soltisz ◽  
Sailaja Paruchuri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Cancer Cells ◽  
High Throughput ◽  
High Throughput Screening ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Natural Compounds ◽  
Screening Technology

A high throughput screening technology enables identifying natural compounds, phytochemicals, that potently inhibit migration of metastatic breast cancer cells.

scholarly journals Cas-CLIP: a method for customizing pooled CRISPR libraries

2018 ◽  
Author(s):  
Jiyeon Kweon ◽  
Da-eun Kim ◽  
An-Hee Jang ◽  
Yongsub Kim
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Target Genes ◽  
Biological Processes ◽  
Precise Method ◽  
Library Construction ◽  
Expensive Process ◽  
Screening Technology

ABSCTRACTAlthough pooled CRISPR libraries are widely used in high-throughput screening to study various biological processes, library construction for researcher’s own study is a time-consuming, labor-intensive, and expensive process. In this study, we develop a simple, scalable method, called Cas-CLIP, to customize conventional pooled CRISPR libraries using the CRISPR/Cas9 system. We show that conventional pooled CRISPR libraries can be modified by eliminating gRNAs that target positive genes, enabling the identification of unknown target genes in CRISPR screening. Cas-CLIP is a precise method for customizing conventional pooled CRISPR libraries and will broaden the scope of high-throughput screening technology.

The maturation of DNA encoded libraries: opportunities for new users

2020 ◽  
Author(s):  
Daniel Conole ◽  
James H Hunter ◽  
Michael J Waring
Keyword(s):  
Data Analysis ◽  
Cost Effectiveness ◽  
Drug Discovery ◽  
High Throughput ◽  
High Throughput Screening ◽  
New Technology ◽  
Combinatorial Libraries ◽  
Library Design ◽  
First Time ◽  
Screening Technology

DNA-encoded combinatorial libraries (DECLs) represent an exciting new technology for high-throughput screening, significantly increasing its capacity and cost–effectiveness. Historically, DECLs have been the domain of specialized academic groups and industry; however, there has recently been a shift toward more drug discovery academic centers and institutes adopting this technology. Key to this development has been the simplification, characterization and standardization of various DECL subprotocols, such as library design, affinity screening and data analysis of hits. This review examines the feasibility of implementing DECL screening technology as a first-time user, particularly in academia, exploring the some important considerations for this, and outlines some applications of the technology that academia could contribute to the field.

Abstract 4206: Utilizing a Drosophila high throughput screening technology for cancer drug discovery

2010 ◽  
Author(s):  
Elena M. Gracheva ◽  
Eduardo J. Martinez ◽  
Jill Thompson ◽  
Dominick Thompson ◽  
Ross L. Cagan
Keyword(s):  
Drug Discovery ◽  
High Throughput ◽  
High Throughput Screening ◽  
Cancer Drug ◽  
Cancer Drug Discovery ◽  
Screening Technology
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