scholarly journals Stevens‐Johnson syndrome/toxic epidermal necrolysis‐like acute cutaneous lupus erythematosus in a patient with systemic lupus erythematosus

2021 ◽  
Author(s):  
Aya Tanaka ◽  
Shota Bun
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Toxic Epidermal Necrolysis ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Stevens Johnson Syndrome ◽  
Systemic Lupus ◽  
Johnson Syndrome ◽  
Cutaneous Lupus

Systemic Lupus Erythematosus Presenting as Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

2014 ◽  
Vol 20 (3) ◽  
pp. 167-171 ◽  
Author(s):  
Mary Grace Baker ◽  
Nicole D. Cresce ◽  
Mariam Ameri ◽  
Adam A. Martin ◽  
James W. Patterson ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Toxic Epidermal Necrolysis ◽  
Lupus Erythematosus ◽  
Stevens Johnson Syndrome ◽  
Systemic Lupus ◽  
Johnson Syndrome

scholarly journals A Rare Presentation of Toxic Epidermal Necrolysis – Like Acute Systemic Lupus Erythematosus

2018 ◽  
Vol 2 (2) ◽  
pp. 144-149
Author(s):  
Brandon T Beal ◽  
Taryn Blaha ◽  
David D Xiong ◽  
Sarah H Schneider ◽  
Steven D Billings ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Toxic Epidermal Necrolysis ◽  
Lupus Erythematosus ◽  
Stevens Johnson Syndrome ◽  
Direct Immunofluorescence ◽  
Systemic Lupus ◽  
Rare Presentation ◽  
Johnson Syndrome ◽  
Perivascular Infiltrate ◽  
Erythematous Plaques

A 25-year-old woman with a history of systemic lupus erythematosus (SLE) was transferred from an outside hospital with a worsening painful generalized rash and oral ulcerations for the prior 3 weeks due to concern for Stevens-Johnson Syndrome / toxic epidermal necrolysis (TEN). Exam revealed denuded erythematous plaques covering over 80% of the patient’s body surface area and a 4.2 x 2.6 cm ulcerated plaque of the superior hard palate. Histology demonstrated parakeratosis and compact hyperkeratosis overlying an atrophic epidermis with vacuolar interface change, prominent keratinocyte dyskeratosis, and a thickened basement membrane zone (BMZ). The superficial dermis had a mild predominantly lymphocytic perivascular infiltrate and superficial dermal mucin deposition. Direct immunofluorescence was positive for IgG (granular, BMZ), C3 (granular, BMZ), and IgA was negative. Labs were remarkable for positive ANA (1:160), ds-DNA, anti-Smith, anti-RNP, low C3/C4, with negative anti-SSA/SSB. The clinicopathological correlation was most consistent with the diagnosis of TEN-like acute systemic lupus erythematosus (TEN-like ASLE). Our patient improved with treatment for her ASLE. This case highlights a challenging clinicopathologic differential diagnosis.

scholarly journals Cutaneous Manifestations of “Lupus”: Systemic Lupus Erythematosus and Beyond

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Elizabeth E. Cooper ◽  
Catherine E. Pisano ◽  
Samantha C. Shapiro
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Treatment ◽  
Treatment Options ◽  
Cutaneous Lupus Erythematosus ◽  
Laboratory Studies ◽  
Systemic Lupus ◽  
Cutaneous Manifestations ◽  
Distinct Disease ◽  
Cutaneous Lupus

Lupus, Latin for “wolf,” is a term used to describe many dermatologic conditions, some of which are related to underlying systemic lupus erythematosus, while others are distinct disease processes. Cutaneous lupus erythematosus includes a wide array of visible skin manifestations and can progress to systemic lupus erythematosus in some cases. Cutaneous lupus can be subdivided into three main categories: acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus. Physical exam, laboratory studies, and histopathology enable differentiation of cutaneous lupus subtypes. This differentiation is paramount as the subtype of cutaneous lupus informs upon treatment, disease monitoring, and prognostication. This review outlines the different cutaneous manifestations of lupus erythematosus and provides an update on both topical and systemic treatment options for these patients. Other conditions that utilize the term “lupus” but are not cutaneous lupus erythematosus are also discussed.

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