Enantioselective chromatography of the antimalarial agents chloroquine, mefloquine, and enpiroline on a ?1 -acid glycoprotein chiral stationary phase: Evidence for a multiple-site chiral recognition mechanism

Chirality ◽  
1992 ◽  
Vol 4 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Anne-Fran�Coise Aubry ◽  
Fran�Cois Gimenez ◽  
Robert Farinotti ◽  
Irving W. Wainer
Keyword(s):  
Stationary Phase ◽  
Chiral Recognition ◽  
Chiral Stationary Phase ◽  
Multiple Site ◽  
Recognition Mechanism ◽  
Chiral Recognition Mechanism ◽  
Acid Glycoprotein ◽  
Antimalarial Agents ◽  
Enantioselective Chromatography

Resolution, determination of enantiomeric purity and chiral recognition mechanism of new xanthone derivatives on (S ,S )-whelk-O1 stationary phase

Chirality ◽  
2017 ◽  
Vol 29 (6) ◽  
pp. 247-256 ◽  
Author(s):  
Maria L. Carraro ◽  
Andreia Palmeira ◽  
Maria E. Tiritan ◽  
Carla Fernandes ◽  
Madalena M.M. Pinto
Keyword(s):  
Stationary Phase ◽  
Chiral Recognition ◽  
Enantiomeric Purity ◽  
Recognition Mechanism ◽  
Chiral Recognition Mechanism ◽  
Xanthone Derivatives

scholarly journals Synthesis of a Novel Chiral Stationary Phase by (R)-1,1′-Binaphthol and the Study on Mechanism of Chiral Recognition

Symmetry ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 704 ◽  
Author(s):  
Yongxi Wang ◽  
Dandan Liu ◽  
Yili Zhang ◽  
Yanmei Tang ◽  
Jingfeng Zhao ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Recognition ◽  
Chiral Stationary Phase ◽  
Separation Mechanism ◽  
The Novel ◽  
Experimental Conditions ◽  
Element Analysis ◽  
Recognition Mechanism ◽  
New Material ◽  
Conjugated Compounds

(R)-6-Acrylic-BINOL CSP, a novel chiral stationary phase was prepared by (R)-Binaphthol (R-BINOL) by introducing the acrylic group into the 6-position of (R)-BINOL before bonding it to the surface of silica gel. The structure of the CSP was characterized by IR, SEM, and element analysis. This new material was tested for its potential as a CSP for HPLC under normal phase conditions, especially for conjugated compounds. Six solutes were chosen to evaluate the chiral separation ability of the novel CSP. The effects of the mobile phase and temperature on enantioseparation were studied, and the chiral recognition mechanism was also discussed. The results showed that the space adaptability and π-π stacking between the solutes and the CSP affected the retention and enantioseparation. The Van’t Hoff curve indicated that under the experimental conditions, the separation mechanism of six solutes did not change, which were all enthalpy driven.

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