A miniaturized analytical method based on molecularly imprinted absorbents for selective extraction of ( S )‐1,1′‐binaphthyl‐2,2′‐diamine and combinatorial screening of polymer precursors by computational simulation

Chirality ◽  
2021 ◽  
Author(s):  
Xin Xu ◽  
Feng Huo ◽  
Yongxia Zhu ◽  
Hongxing Dong ◽  
Yanhui Wang ◽  
...  
Keyword(s):  
Analytical Method ◽  
Computational Simulation ◽  
Selective Extraction ◽  
Combinatorial Screening ◽  
Molecularly Imprinted ◽  
Polymer Precursors

scholarly journals A Molecularly Imprinted Polymer for Selective Extraction of Phenolic Acids from Human Urine

2021 ◽  
Vol 11 (4) ◽  
pp. 1577
Author(s):  
Marco Mora-Granados ◽  
David González-Gómez ◽  
Jin Su Jeong ◽  
Alejandrina Gallego-Picó
Keyword(s):  
Phenolic Acids ◽  
Molecularly Imprinted Polymer ◽  
Human Urine ◽  
Limit Of Detection ◽  
Ph Dependence ◽  
Selective Extraction ◽  
Screening Methods ◽  
Specific Method ◽  
Imprinted Polymer ◽  
Molecularly Imprinted

Studies for monitoring the bioavailability of dietary flavonoid compounds generate great interest. Among them, low-molecular-weight phenolic acids, secondary metabolites present in colonic catabolism and urinary excretion, have been proposed as biomarkers of polyphenol intake. Using 4-hydroxyphenylacetic acid as a template, a molecularly imprinted polymer (MIP) was synthesized for selective extraction of these hydroxylated metabolites from human urine samples and posterior analysis in an HPLC-DAD-MS system. Polymers were characterized by Scanning electron microscopy (SEM), Attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), Brunauer-Emmett-Teller (BET) method, and binding experiments. MIP presents specific recognition ability for template and analogues molecules. This capacity of recognition and the pH dependence of the binding strength was also studied. The method was validated over a concentration range of 0.25–40 mg/L, r2 > 0.995. In the optimized conditions, the recovery value was 94% with RSD 1.2%. The Limit of Detection (LOD) and Limit of Quantification (LOQ) were 1.22 and 3.69 mg/L, respectively. In our knowledge, it is the first time that this methodology is applied to analyze urinary catabolites of the polyphenol compound and to provide a specific method and simple analysis alternative. The selective extraction of these metabolites improves the application and results obtained by other less sensitive analysis methods than the validation method. It also facilitates the development of new screening methods.

Selective extraction of progesterone hormones from environmental and biological samples using a polypyrrole molecularly imprinted polymer and determination by gas chromatography

2016 ◽  
Vol 8 (8) ◽  
pp. 1813-1827 ◽  
Author(s):  
A. Nezhadali ◽  
Z. Es’haghi ◽  
A. Khatibi
Keyword(s):  
Gas Chromatography ◽  
Molecularly Imprinted Polymer ◽  
Biological Samples ◽  
Selective Extraction ◽  
Chemical Oxidation ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Batch Extraction ◽  
Environmental And Biological Samples

A Molecularly Imprinted Polymer (MIP) was chemically prepared for the selective batch extraction of progesterone (PGN) hormones by chemical oxidation of pyrrole using FeCl3.

Synthesis and characterization of molecularly imprinted polymers with modified rosin as a cross-linker and selective SPE-HPLC detection of basic orange II in foods

2014 ◽  
Vol 6 (16) ◽  
pp. 6397-6406 ◽  
Author(s):  
Xiaoyan Li ◽  
Mei Li ◽  
Junjie Li ◽  
Fuhou Lei ◽  
Xiaomeng Su ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Selective Extraction ◽  
Synthesis And Characterization ◽  
Orange Ii ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Cross Linker

A novel sample clean-up technique, i.e., molecularly imprinted solid-phase extraction (MISPE) combined with HPLC, was developed and validated for the selective extraction and determination of basic orange II in foods.

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