Simultaneous separation of atenolol enantiomers and its acid/alkaline degradation impurities on mixed‐mode chiral ligand exchange stationary phases

Chirality ◽  
2021 ◽  
Author(s):  
Hui Bai ◽  
Lei Chen
Keyword(s):  
Ligand Exchange ◽  
Mixed Mode ◽  
Stationary Phases ◽  
Chiral Ligand ◽  
Alkaline Degradation ◽  
Simultaneous Separation ◽  
Chiral Ligand Exchange

New chemically bonded chiral ligand-exchange chromatographic stationary phases

1994 ◽  
Vol 666 (1-2) ◽  
pp. 91-97 ◽  
Author(s):  
G. Gübitz ◽  
S. Mihellyes ◽  
G. Kobinger ◽  
A. Wutte
Keyword(s):  
Ligand Exchange ◽  
Stationary Phases ◽  
Chiral Ligand ◽  
Chiral Ligand Exchange

scholarly journals Research progress of chiral ligand exchange stationary phases in the enantiomer resolution

2021 ◽  
Vol 271 ◽  
pp. 04020
Author(s):  
Hui Bai
Keyword(s):  
Quality Control ◽  
Ligand Exchange ◽  
Stationary Phases ◽  
Research Progress ◽  
Chiral Ligand ◽  
Enantiomeric Resolution ◽  
Chiral Drugs ◽  
Enantiomer Resolution ◽  
Chiral Ligand Exchange

The structure of chiral drugs contains at least one asymmetric center. When the enantiomers act on the human body, they are recognized by chiral receptors and enzymes in vivo, which will show different physiological effects and even adverse reactions. Therefore, it is very important for the development of chiral pharmacy to obtain chiral enantiomers with a single configuration by racemic resolution. Some general impurities will be introduced in the production of chiral drugs, thus the detection of impurities is also a crucial step in the quality control of chiral medicines. The chiral ligand exchange stationary phase has a strong recognition effect on enantiomer analytes with multiple chelating sites, and is very suitable for the separation and control of biological samples such as amino acids. In this work, the development of chiral ligand exchange stationary phases in enantiomeric resolution is reviewed, which is expected to provide a basis for the quality control of complex chiral drug components.

Separation of fudosteine on an achiral C18column by HPLC with chiral ligand-exchange selectors as mobile phase additives

2008 ◽  
Vol 20 (4) ◽  
pp. 585-594 ◽  
Author(s):  
J. Ma ◽  
J. Cao ◽  
M. J. Ding ◽  
L. H. Yuan ◽  
M. J. Zhai ◽  
...  
Keyword(s):  
Ligand Exchange ◽  
Mobile Phase ◽  
Chiral Ligand ◽  
Mobile Phase Additives ◽  
Chiral Ligand Exchange

Chitosan chiral ligand exchange membranes for sorption resolution of amino acids

2009 ◽  
Vol 64 (7) ◽  
pp. 1462-1473 ◽  
Author(s):  
Hai-Dong Wang ◽  
Rui Xie ◽  
Catherine Hui Niu ◽  
Hang Song ◽  
Mei Yang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ligand Exchange ◽  
Chiral Ligand ◽  
Chiral Ligand Exchange

Isoleucine ionic liquids as additives to separate mandelic acid and their derivative enantiomers by HPLC

2014 ◽  
Vol 6 (15) ◽  
pp. 5627-5631 ◽  
Author(s):  
Jie Zhou ◽  
Suzhen Zhao ◽  
Guangjun Fu ◽  
Zhenzhong Zhang
Keyword(s):  
Ionic Liquids ◽  
Ligand Exchange ◽  
Mandelic Acid ◽  
Exchange Chromatography ◽  
Chiral Ligands ◽  
Chiral Ligand ◽  
Ligand Exchange Chromatography ◽  
Chiral Ligand Exchange

In this study, functional isoleucine ionic liquids were synthesized and used as novel chiral ligands coordinated with Cu(ii) in chiral ligand exchange chromatography.

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