Chiral separation and modeling of quinolones on teicoplanin macrocyclic glycopeptide antibiotics CSP

Chirality ◽  
2018 ◽  
Vol 30 (12) ◽  
pp. 1304-1311 ◽  
Author(s):  
Imran Ali ◽  
Mohd Suhail ◽  
Leonid Asnin
Keyword(s):  
Chiral Separation ◽  
Glycopeptide Antibiotics ◽  
Macrocyclic Glycopeptide

scholarly journals Enantioselective Liquid Chromatographic Separations Using Macrocyclic Glycopeptide-Based Chiral Selectors

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3380
Author(s):  
Róbert Berkecz ◽  
Dániel Tanács ◽  
Antal Péter ◽  
István Ilisz
Keyword(s):  
Liquid Chromatography ◽  
Stationary Phases ◽  
Practical Importance ◽  
Food Additives ◽  
Chemical Properties ◽  
Chiral Stationary Phases ◽  
Glycopeptide Antibiotics ◽  
Enantiomeric Separations ◽  
Chiral Selectors ◽  
Macrocyclic Glycopeptide

Numerous chemical compounds of high practical importance, such as drugs, fertilizers, and food additives are being commercialized as racemic mixtures, although in most cases only one of the isomers possesses the desirable properties. As our understanding of the biological actions of chiral compounds has improved, the investigation of the pharmacological and toxicological properties has become more and more important. Chirality has become a major issue in the pharmaceutical industry; therefore, there is a continuous demand to extend the available analytical methods for enantiomeric separations and enhance their efficiency. Direct liquid chromatography methods based on the application of chiral stationary phases have become a very sophisticated field of enantiomeric separations by now. Hundreds of chiral stationary phases have been commercialized so far. Among these, macrocyclic glycopeptide-based chiral selectors have proved to be an exceptionally useful class of chiral selectors for the separation of enantiomers of biological and pharmacological importance. This review focuses on direct liquid chromatography-based enantiomer separations, applying macrocyclic glycopeptide-based chiral selectors. Special attention is paid to the characterization of the physico-chemical properties of these macrocyclic glycopeptide antibiotics providing detailed information on their applications published recently.

Chiral separation of β-blockers after derivatization with (-)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride by gas chromatography

2001 ◽  
Vol 24 (5) ◽  
pp. 402-406 ◽  
Author(s):  
Kyeong Ho Kim ◽  
Joo Hyun Lee ◽  
Mi Young Ko ◽  
Seon-Pyo Hong ◽  
Jeong Rok Youm
Keyword(s):  
Gas Chromatography ◽  
Chiral Separation ◽  
Β Blockers

scholarly journals Immobilization of Trypsin onto Porous Methacrylate-Based Monolith for Flow-through Protein Digestion and Its Potential Application to Chiral Separation Using Liquid Chromatography

Heliyon ◽  
2021 ◽  
pp. e07707
Author(s):  
Suci Amalia ◽  
Stevin Carolius Angga ◽  
Elvina Dhiaul Iftitah ◽  
Dias Septiana ◽  
Baiq Octaviana D. Anggraeny ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Chiral Separation ◽  
Potential Application ◽  
Protein Digestion ◽  
Flow Through
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