Comparison of three S-β-CDs with different degrees of substitution for the chiral separation of 12 drugs in capillary electrophoresis

Chirality ◽  
2017 ◽  
Vol 29 (9) ◽  
pp. 558-565 ◽  
Author(s):  
Zhaokun Wang ◽  
Qiongwen Zhang ◽  
Linda Luo ◽  
Tiemin Sun ◽  
Xingjie Guo
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation

scholarly journals Chiral Selectors in Capillary Electrophoresis: Trends During 2017–2018

Molecules ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1135 ◽  
Author(s):  
Raymond B. Yu ◽  
Joselito P. Quirino
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Mass ◽  
Chiral Separation ◽  
Chiral Separations ◽  
Water Soluble ◽  
Resonance Spectroscopy ◽  
Electrokinetic Chromatography ◽  
Chiral Selectors ◽  
Analytical Technique ◽  
Pharmaceutical Industries

Chiral separation is an important process in the chemical and pharmaceutical industries. From the analytical chemistry perspective, chiral separation is required for assessing the fit-for-purpose and the safety of chemical products. Capillary electrophoresis, in the electrokinetic chromatography mode is an established analytical technique for chiral separations. A water-soluble chiral selector is typically used. This review therefore examines the use of various chiral selectors in electrokinetic chromatography during 2017–2018. The chiral selectors were both low and high (macromolecules) molecular mass molecules as well as molecular aggregates (supramolecules). There were 58 papers found by search in Scopus, indicating continuous and active activity in this research area. The macromolecules were sugar-, amino acid-, and nucleic acid-based polymers. The supramolecules were bile salt micelles. The low molecular mass selectors were mainly ionic liquids and complexes with a central ion. A majority of the papers were on the use or preparation of sugar-based macromolecules, e.g., native or derivatised cyclodextrins. Studies to explain chiral recognition of macromolecular and supramolecular chiral selectors were mainly done by molecular modelling and nuclear magnetic resonance spectroscopy. Demonstrations were predominantly on drug analysis for the separation of racemates.

Chiral separation of cetirizine by capillary electrophoresis

2006 ◽  
Vol 27 (12) ◽  
pp. 2376-2385 ◽  
Author(s):  
Ann Van Eeckhaut ◽  
Yvette Michotte
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation

scholarly journals Application of Hadamard transformation to chiral separation by capillary electrophoresis

2003 ◽  
Vol 52 (12) ◽  
pp. 1193-1197 ◽  
Author(s):  
Takashi KANETA ◽  
Miki NISHIDA ◽  
Totaro IMASAKA
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Hadamard Transformation

Study on improvement of chiral separation of capillary electrophoresis based on cyclodextrin by deep eutectic solvents

Talanta ◽  
2020 ◽  
Vol 220 ◽  
pp. 121419 ◽  
Author(s):  
Suya Deng ◽  
Jingmiao Pan ◽  
Min Wang ◽  
Yike Huang ◽  
Zhining Xia
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation ◽  
Deep Eutectic Solvents

Chiral separation of highly negatively charged enantiomers by capillary electrophoresis

2004 ◽  
Vol 1033 (2) ◽  
pp. 349-356 ◽  
Author(s):  
Qinfeng Liu ◽  
Takayo Inoue ◽  
Jon R. Kirchhoff ◽  
Chunli Huang ◽  
L.M.V. Tillekeratne ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Separation
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