Factors screening to statistical experimental design of racemic atenolol kinetic resolution via transesterification reaction in organic solvent using free Pseudomonas fluorescens lipase

Chirality ◽  
2017 ◽  
Vol 29 (7) ◽  
pp. 376-385 ◽  
Author(s):  
Joni Agustian ◽  
Azlina Harun Kamaruddin ◽  
Hassan Y. Aboul-Enein
Keyword(s):  
Experimental Design ◽  
Organic Solvent ◽  
Pseudomonas Fluorescens ◽  
Kinetic Resolution ◽  
Transesterification Reaction ◽  
Statistical Experimental Design

Enantio-conversion and -selectivity of racemic atenolol kinetic resolution using free Pseudomonas fluorescens lipase (Amano) conducted via transesterification reaction

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 26077-26085 ◽  
Author(s):  
Joni Agustian ◽  
Azlina Harun Kamaruddin ◽  
Hassan Y. Aboul-Enein
Keyword(s):  
Pseudomonas Fluorescens ◽  
Kinetic Resolution ◽  
Enantiomeric Purity ◽  
Transesterification Reaction ◽  
Reaction Parameters ◽  
Pharmacologically Active

Effects of reaction parameters on kinetic resolution of racemic atenolol usingPseudomonas fluorescenslipase were investigatedviatransesterification for production of pharmacologically active eutomer (S)-atenolol with high enantiomeric purity.

Kinetic resolution of heptan-2-ol-enantiomers by lipase-catalysed esteri�ication in organic solvent

1989 ◽  
Vol 188 (2) ◽  
pp. 144-147
Author(s):  
Karl-Heinz Engel ◽  
Martina Bohnen ◽  
Roland Tressl
Keyword(s):  
Organic Solvent ◽  
Kinetic Resolution

A Statistical Experimental Design to Plastein Synthesis with the Mixture of Soy Protein Isolate(SPI) Hydrolysate and Whey Protein Isolate(WPI) Hydrolysate

2011 ◽  
Vol 236-238 ◽  
pp. 2773-2779
Author(s):  
Ying Cao Xu ◽  
Zhi Biao Feng ◽  
Chun Hong Liu
Keyword(s):  
Experimental Design ◽  
Whey Protein ◽  
Soy Protein ◽  
Soy Protein Isolate ◽  
Whey Protein Isolate ◽  
Protein Isolate ◽  
Statistical Experimental Design ◽  
Operating Variables ◽  
Enzyme Substrate ◽  
Predicted Values

A statistical experimental design to plastein synthesis which was catalyzed by transglutaminase, using the mixture of soy protein isolate(SPI) hydrolysate and whey protein isolate (WPI) hydrolysate, was investigated. Enzyme/Substrate(E/S:5-25U/g), pH(5-9) and temperature (35-65°C) were selected as major operating variables. To investigate the effects of variables to yield of plastein, the statistical experiment of Box-Behnken design(BBD) and Response Surface methodology(RSM) was employed. Regression analysis showed that the experiment data accorded with the predicted values obtained from quadratic regression equation in BBD with R-Squared of 0.9866 and F-value of 102.51. The optimum results estimated by BBD were as follows: E/S(19.5U/g), pH(6.8), and temperature(50.0°C), gave a maximum plastein yield of 54%. In the present experiment, the preliminary study on plastein functions such as foaming, emulsifying, were showed that plastein had a good biological function.

Exploration of the expeditious potential of Pseudomonas fluorescens lipase in the kinetic resolution of racemic intermediates and its validation through molecular docking

Chirality ◽  
2017 ◽  
Vol 30 (1) ◽  
pp. 85-94 ◽  
Author(s):  
Surbhi Soni ◽  
Bharat P. Dwivedee ◽  
Vishnu K. Sharma ◽  
Gopal Patel ◽  
Uttam C. Banerjee
Keyword(s):  
Molecular Docking ◽  
Pseudomonas Fluorescens ◽  
Kinetic Resolution

Chitinase Production in Solid-State Fermentation by Enterobacter sp. NRG4 Using Statistical Experimental Design

2005 ◽  
Vol 51 (4) ◽  
pp. 222-228 ◽  
Author(s):  
Neetu Dahiya ◽  
Rupinder Tewari ◽  
Ram Prakash Tiwari ◽  
Gurinder Singh Hoondal
Keyword(s):  
Solid State ◽  
Experimental Design ◽  
Solid State Fermentation ◽  
Statistical Experimental Design ◽  
Chitinase Production
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