A Validated Normal Phase LC Method for Enantiomeric Separation of Rasagiline Mesylate and Its (S )-Enantiomer on Cellulose Derivative-Based Chiral Stationary Phase

Chirality ◽  
2013 ◽  
Vol 25 (6) ◽  
pp. 324-327 ◽  
Author(s):  
P. Sunil Reddy ◽  
K. Sudhakar Babu ◽  
Navneet Kumar
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Normal Phase ◽  
Cellulose Derivative ◽  
Rasagiline Mesylate

scholarly journals Enantiomeric Separation and Molecular Modelling of Bioactive 4-aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase

Separations ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 7
Author(s):  
Isabella Bolognino ◽  
Antonio Carrieri ◽  
Rosa Purgatorio ◽  
Marco Catto ◽  
Rocco Caliandro ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Molecular Descriptors ◽  
Enantiomeric Separation ◽  
Normal Phase ◽  
Chiral Selector ◽  
X Ray ◽  
Enantioselective Recognition ◽  
Highly Active ◽  
Molecular Dynamics Calculations

The enantiomeric separation of 15 racemic 4-aryl-3,4-dihydropyrimidin-2(1H)-one (DHP) alkoxycarbonyl esters, some of which proved to be highly active as A2B adenosine receptor antagonists, was carried out by HPLC on ChirobioticTM TAG, a chiral stationary phase (CSP) bearing teicoplanin aglycone (TAG) as the chiral selector. The racemic compounds were separated under polar organic (PO) conditions. Preliminarily, the same selectands were investigated on three different Pirkle-type CSPs in normal-phase (NP) conditions. A baseline separation was successfully obtained on TAG-based CSPs for the majority of compounds, some of which achieved high enantioselectivity ratios (α > 2) in contrast with the smaller α values (1–1.5) and the lack of baseline resolution observed with the Pirkle-type CSPs. In particular, the racemic tetrazole-fused DHP ester derivatives, namely compounds 8 and 9, were separated on TAG-based HPLC columns with noteworthy α values (8.8 and 6.0, respectively), demonstrating the potential of the method for preparative purposes. A competition experiment, carried out with a racemic analyte (6) by adding N-acetyl-d-alanine (NADA) to the mobile phase, suggested that H-bonding interactions involved in the recognition of the natural dipeptide ligand d-Ala-d-Ala into the TAG cleft should be critical for enantioselective recognition of 4-aryl DHPs by TAG. The X-ray crystal structure of TAG was elucidated at a 0.77 Å resolution, whereas the calculation of molecular descriptors of size, polar, and H-bond interactions, were complemented with molecular docking and molecular dynamics calculations, shedding light on repulsive (steric effects) and attractive (H-bond—polar and apolar) interactions between 4-aryl DHP selectands and TAG chiral selectors.

Enantioseparation of novel chiral tetrahedral clusters on an amylose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase by normal phase HPLC

2010 ◽  
Vol 22 (10) ◽  
pp. 1070-1074 ◽  
Author(s):  
Wen-Zhi Li ◽  
Xia Wang ◽  
Wei-Qiang Zhang ◽  
Chen Li-Ren ◽  
Yong-Min Li ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Normal Phase ◽  
Normal Phase Hplc

Enantioselective Gas Chromatographic Separation of Racemic N-alkylated Barbiturates: Application of C11-Chirasil-Dex as Chiral Stationary Phase in GC

2007 ◽  
Vol 2 ◽  
pp. 117739010700200
Author(s):  
Ashraf Ghanem
Keyword(s):  
Gas Chromatography ◽  
Stationary Phase ◽  
Chromatographic Separation ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Enantioselective Gas Chromatography ◽  
Gas Chromatographic Separation ◽  
New Stationary Phase

Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as chiral stationary phase (CSP) in enantioselective gas chromatography (GC). The versatility of the new stationary phase in the simultaneous enantiomeric separation of a set of N-alkylated barbiturates is demonstrated.

Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC

2018 ◽  
Vol 42 (14) ◽  
pp. 11724-11731 ◽  
Author(s):  
Meng Li ◽  
Bo Zhang ◽  
Jia Yu ◽  
Jian Wang ◽  
Xingjie Guo
Keyword(s):  
Stationary Phase ◽  
Simulation Study ◽  
Chiral Recognition ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Separation Process ◽  
Anticholinergic Drugs

Enantiomeric separation process of anticholinergic drugs and chiral recognition mechanisms on Chiralpak ID column.

Enantiomeric Separation of (±)-Amino Acid Esters on (−)-Phenylurea Chiral Stationary Phase

1999 ◽  
Vol 63 (1) ◽  
pp. 18-23
Author(s):  
Kwang-Pill Lee ◽  
Hyun-Bong Lee ◽  
Young Cheol Lee ◽  
Seong-Ho Choi ◽  
Jae Jeong Ryoo ◽  
...  
Keyword(s):  
Amino Acid ◽  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Amino Acid Esters ◽  
Acid Esters
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