Comparison of Chiral Separations of Aminophosphonic Acids and Their Aminocarboxylic Acid Analogs Using a Crown Ether Column

Chirality ◽  
2013 ◽  
Vol 25 (7) ◽  
pp. 369-378 ◽  
Author(s):  
Wesley W. Barnhart ◽  
Xiaoyang Xia ◽  
Randy Jensen ◽  
Kyung H. Gahm
2020 ◽  
Vol 2 (1) ◽  
pp. 1-12
Author(s):  
Gulgina Mamtimin ◽  
Halisa Arkin ◽  
Patima Nizamidin ◽  
Erkin Tursun ◽  
Abliz Yimit

2019 ◽  
Vol 576 ◽  
pp. 182-189 ◽  
Author(s):  
Zhuliu Xiao ◽  
Binghua Zhou ◽  
Jirong Wang ◽  
Cai Zuo ◽  
Dan He ◽  
...  

2008 ◽  
Vol 47 (3) ◽  
pp. 1218-1223 ◽  
Author(s):  
Mei-Jin Li ◽  
Zuofeng Chen ◽  
Nianyong Zhu ◽  
Vivian Wing-Wah Yam ◽  
Yanbing Zu
Keyword(s):  

2021 ◽  
Author(s):  
Imran Ali ◽  
Mohd. Suhail ◽  
Hassan Y. Aboul-Enein ◽  
Tatiana Kon’kova

Author(s):  
Kai Guo ◽  
Sitong Liu ◽  
Haoming Tu ◽  
Zhikun Wang ◽  
Liang Chen ◽  
...  

Crown ethers could serve as hosts to selectively incorporate various guest atoms or molecules within the macrocycles. However, the high flexibility of crown ether molecules limits their applications in areas...


Separations ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 112
Author(s):  
Marine Morvan ◽  
Ivan Mikšík

Like many biological compounds, proteins are found primarily in their homochiral form. However, homochirality is not guaranteed throughout life. Determining their chiral proteinogenic sequence is a complex analytical challenge. This is because certain D-amino acids contained in proteins play a role in human health and disease. This is the case, for example, with D-Asp in elastin, β-amyloid and α-crystallin which, respectively, have an action on arteriosclerosis, Alzheimer's disease and cataracts. Sequence-dependent and sequence-independent are the two strategies for detecting the presence and position of D-amino acids in proteins. These methods rely on enzymatic digestion by a site-specific enzyme and acid hydrolysis in a deuterium or tritium environment to limit the natural racemization of amino acids. In this review, chromatographic and electrophoretic techniques, such as LC, SFC, GC and CE, will be recently developed (2018–2020) for the enantioseparation of amino acids and peptides. For future work, the discovery and development of new chiral stationary phases and derivatization reagents could increase the resolution of chiral separations.


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