Liquid chromatographic retention behavior and enantiomeric separation of three chiral center ?-blocker drug (nadolol) using heptakis (6-azido-6-deoxy-2, 3-di-O-phenylcarbamolyted) ?-cyclodextrin bonded chiral stationary phase

Chirality ◽  
2002 ◽  
Vol 14 (10) ◽  
pp. 798-805 ◽  
Author(s):  
Xin Wang ◽  
Chi Bun Ching
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Chiral Center ◽  
Chromatographic Retention ◽  
Retention Behavior ◽  
Liquid Chromatographic

Preparation of chiral stationary phase via activated carbamate intermediate for liquid chromatographic optical resolution

1987 ◽  
Vol 23 (10) ◽  
pp. 727-730 ◽  
Author(s):  
K. Iwaki ◽  
S. Yoshida ◽  
N. Nimura ◽  
T. Kinoshita ◽  
K. Takeda ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chiral Stationary Phase ◽  
Optical Resolution ◽  
Liquid Chromatographic

scholarly journals Immobilization of Chondroitin Sulfate A onto Monolithic Epoxy Silica Column as a New Chiral Stationary Phase for High-Performance Liquid Chromatographic Enantioseparation

2021 ◽  
Vol 14 (2) ◽  
pp. 98
Author(s):  
Ratih Ratih ◽  
Hermann Wätzig ◽  
Azminah Azminah ◽  
Mufarreh Asmari ◽  
Benjamin Peters ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Chondroitin Sulfate ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
High Performance Liquid Chromatographic ◽  
Schiff Base Formation ◽  
The Individual ◽  
Liquid Chromatographic ◽  
Base Formation ◽  
Chondroitin Sulfate A

Chondroitin sulfate A was covalently immobilized onto a monolithic silica epoxy column involving a Schiff base formation in the presence of ethylenediamine as a spacer and evaluated in terms of its selectivity in enantioseparation. The obtained column was utilized as a chiral stationary phase in enantioseparation of amlodipine and verapamil using a mobile phase consisting of 50 mM phosphate buffer pH 3.5 and UV detection. Sample dilution by organic solvents (preferably 25% v/v acetonitrile-aqueous solution) was applied to achieve baseline enantioresolution (Rs > 3.0) of the individual drug models within 7 min, an excellent linearity (R2 = 0.999) and an interday repeatability of 1.1% to 1.8% RSD. The performance of the immobilized column for quantification of racemate in commercial tablets showed a recovery of 86–98% from tablet matrices. Computational modeling by molecular docking was employed to investigate the feasible complexes between enantiomers and the chiral selector.

Enantioselective Gas Chromatographic Separation of Racemic N-alkylated Barbiturates: Application of C11-Chirasil-Dex as Chiral Stationary Phase in GC

2007 ◽  
Vol 2 ◽  
pp. 117739010700200
Author(s):  
Ashraf Ghanem
Keyword(s):  
Gas Chromatography ◽  
Stationary Phase ◽  
Chromatographic Separation ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Enantioselective Gas Chromatography ◽  
Gas Chromatographic Separation ◽  
New Stationary Phase

Chirasil-β-Dex containing an undecamethylene spacer (C11-Chirasil-Dex) was synthesized and used as chiral stationary phase (CSP) in enantioselective gas chromatography (GC). The versatility of the new stationary phase in the simultaneous enantiomeric separation of a set of N-alkylated barbiturates is demonstrated.

Enantiomeric separation and simulation study of eight anticholinergic drugs on an immobilized polysaccharide-based chiral stationary phase by HPLC

2018 ◽  
Vol 42 (14) ◽  
pp. 11724-11731 ◽  
Author(s):  
Meng Li ◽  
Bo Zhang ◽  
Jia Yu ◽  
Jian Wang ◽  
Xingjie Guo
Keyword(s):  
Stationary Phase ◽  
Simulation Study ◽  
Chiral Recognition ◽  
Chiral Stationary Phase ◽  
Enantiomeric Separation ◽  
Separation Process ◽  
Anticholinergic Drugs

Enantiomeric separation process of anticholinergic drugs and chiral recognition mechanisms on Chiralpak ID column.

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