ChemInform Abstract: Chemoselective Synthesis of Enamino-Coumarin Derivatives Identified as Potent Antitumor Agents.

ChemInform ◽  
2016 ◽  
Vol 47 (49) ◽  
Author(s):  
Mona E. Ibrahim ◽  
Wafaa S. Hamama ◽  
Asmaa E. Metwalli ◽  
Hanafi H. Zoorob
Keyword(s):  
Antitumor Agents ◽  
Coumarin Derivatives ◽  
Chemoselective Synthesis

Chemoselective Synthesis of Enamino-Coumarin Derivatives Identified as Potent Antitumor Agents

2015 ◽  
Vol 53 (4) ◽  
pp. 1318-1323 ◽  
Author(s):  
Mona E. Ibrahim ◽  
Wafaa S. Hamama ◽  
Asmaa E. Metwalli ◽  
Hanafi H. Zoorob
Keyword(s):  
Antitumor Agents ◽  
Coumarin Derivatives ◽  
Chemoselective Synthesis

Design, synthesis and biological evaluation of novel furoxan-based coumarin derivatives as antitumor agents

2018 ◽  
Vol 27 (4) ◽  
pp. 1198-1205 ◽  
Author(s):  
Zhuo Zhang ◽  
Zhi-Wei Bai ◽  
Yong Ling ◽  
Li-Qin He ◽  
Peng Huang ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Coumarin Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents

2018 ◽  
Vol 9 (5) ◽  
pp. 502-506 ◽  
Author(s):  
Yalan Guo ◽  
Yujie Wang ◽  
Haihong Li ◽  
Ke Wang ◽  
Qi Wan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antitumor Agents ◽  
Nitric Oxide Donors ◽  
Coumarin Derivatives

Coumarin derivatives as potential antitumor agents: Growth inhibition, apoptosis induction and multidrug resistance reverting activity

2017 ◽  
Vol 127 ◽  
pp. 577-585 ◽  
Author(s):  
Alessandra Bisi ◽  
Concettina Cappadone ◽  
Angela Rampa ◽  
Giovanna Farruggia ◽  
Azzurra Sargenti ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Growth Inhibition ◽  
Antitumor Agents ◽  
Coumarin Derivatives ◽  
Apoptosis Induction ◽  
Potential Antitumor

scholarly journals Biochemical Studies on Coumarin Derivatives as Antioxidant and Antitumor Agents

2019 ◽  
pp. 1-16
Author(s):  
F. Z. Mohammed ◽  
I. M. EL-Deen ◽  
A. S. Tmamm
Keyword(s):  
Antitumor Agents ◽  
Antioxidant Activities ◽  
Bromine Atom ◽  
Tumor Model ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Coumarin Derivatives ◽  
Anti Oxidant

Background: Coumarin derivatives have attracted intense interest in recent years, because they have anti-tumor, antioxidant activities, and induce apoptosis. Aims and Objective: Our study aims to evaluate the antitumor and anti-oxidant activities of new Coumarin derivatives: N-(P-chlorophenyl)-7-hydroxycoumarin-3-yl carboxamide and Ethyl 7-hydroxycoumarin-3-yl ester against in vivo tumor model. Methodology: the toxicity for the synthesized compounds was determined. The anticancer and anti-oxidant activities were studied by evaluation the viability of tumor cells, life span prolongation, and estimation of antioxidants. Results: Our compounds exhibited significant anti-oxidant activity towards Ehrlich ascites carcinoma (EAC) cells by reduction the MDA and NO concentration (p<0.001) compared to the positive control group. Whereas significantly increase in the G. peroxidase activity (p<0.001) in treated groups compared to the positive control group. Anticancer agent kills tumors by induction of apoptosis that showing significantly increases in Caspase-3 and Bax activity compared to positive control group. Discussion: The compound N-(P-chlorophenyl)-7-hydroxycoumarin-3-yl carboxamide is better than Ethyl 7-hydroxycoumarin-3-yl ester compound because of the nature of the halogen atom (a chlorine or a bromine atom) in the ‘meta’ position of the phenyl ring relative to the ester oxygen atom of 2-oxo-2H-1-benzopyran- 3-carboxylate led to a better anti-tumor effect than that observed in the absence of any substituent.

Coumarin derivatives from the roots of Heptaptera cilicica

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
Z Güvenalp ◽  
H Özbek ◽  
G Yılmaz ◽  
C Kazaz
Keyword(s):  
Coumarin Derivatives

Chemoselective Synthesis of Aminobenzylic Derivative of Mackinazolinone and its X-ray Investigations

2019 ◽  
Vol 9 (3) ◽  
pp. 109-114
Author(s):  
Nuritdinova R. R. ◽  
Elmuradov B. Zh. ◽  
Okmanov R. Ya. ◽  
Zakhidov K. A. ◽  
Tadjimukhamedov Kh.S.
Keyword(s):  
X Ray ◽  
Chemoselective Synthesis
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