ChemInform Abstract: (+)- and (-)-Ganodilactone, a Pair of Meroterpenoid Dimers with Pancreatic Lipase Inhibitory Activities from the Macromycete Ganoderma leucocontextum.

ChemInform ◽  
2016 ◽  
Vol 47 (48) ◽  
Author(s):  
He-Ping Chen ◽  
Zhen-Zhu Zhao ◽  
Yu Zhang ◽  
Xue Bai ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Inhibitory Activities

scholarly journals Bioactivity-Guided Isolation of Phytochemicals from Vaccinium dunalianum Wight and Their Antioxidant and Enzyme Inhibitory Activities

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2075
Author(s):  
Tianrui Zhao ◽  
Mengxue Sun ◽  
Lingpeng Kong ◽  
Qingwang Xue ◽  
Yudan Wang ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Antioxidant Activities ◽  
Bioactive Components ◽  
Inhibitory Effects ◽  
Macroporous Resin ◽  
Ultrasound Assisted Extraction ◽  
Assisted Extraction ◽  
Ic50 Values ◽  
Trolox Equivalent ◽  
Inhibitory Activities

Vaccinium dunalianum Wight, usually processed as a traditional folk tea beverage, is widely distributed in the southwest of China. The present study aimed to investigate the antioxidant, α-glucosidase and pancreatic lipase inhibitory activities of V.dunalianum extract and isolate the bioactive components. In this study, the crude extract (CE) from the buds of V. dunalianum was prepared by the ultrasound-assisted extraction method in 70% methanol and then purified with macroporous resin D101 to obtain the purified extract (PM). Five fractions (Fr. A–E) were further obtained by MPLC column (RP-C18). Bioactivity assays revealed that Fr. B with 40% methanol and Fr. D with 80% methanol had better antioxidant with 0.48 ± 0.03 and 0.62 ± 0.01 nM Trolox equivalent (TE)/mg extract for DPPH, 0.87 ± 0.02 and 1.58 ± 0.02 nM TE/mg extract for FRAP, 14.42 ± 0.41 and 19.25 ± 0.23 nM TE/mg extract for ABTS, and enzyme inhibitory effects with IC50 values of 95.21 ± 2.21 and 74.55 ± 3.85 for α-glucosidase, and 142.53 ± 11.45 and 128.76 ± 13.85 µg/mL for pancreatic lipase. Multivariate analysis indicated that the TPC and TFC were positively related to the antioxidant activities. Further phytochemical purification led to the isolation of ten compounds (1–10). 6-O-Caffeoylarbutin (7) showed significant inhibitory effects on α-glucosidase and pancreatic lipase enzymes with values of 38.38 ± 1.84 and 97.56 ± 7.53 µg/mL, and had the highest antioxidant capacity compared to the other compounds.

Citrinin and α-pyrone derivatives with pancreatic lipase inhibitory activities from Penicillium sp. SCSIO 41302

2021 ◽  
pp. 1-10
Author(s):  
Wen-Rong Han ◽  
Meng-Meng Song ◽  
Yi-Wei Hu ◽  
Xiao-Yan Pang ◽  
Sheng-Rong Liao ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Penicillium Sp ◽  
Inhibitory Activities

Isolation and identification of cholesterol esterase and pancreatic lipase inhibitory peptides from brewer's spent grain by consecutive chromatography and mass spectrometry

2020 ◽  
Vol 11 (6) ◽  
pp. 4994-5003
Author(s):  
Antonela Guadalupe Garzón ◽  
Raúl Esteban Cian ◽  
Marilin Estefanía Aquino ◽  
Silvina Rosa Drago
Keyword(s):  
Mass Spectrometry ◽  
Pancreatic Lipase ◽  
Cholesterol Esterase ◽  
Added Value ◽  
Isolation And Identification ◽  
Brewer’S Spent Grain ◽  
Inhibitory Peptides ◽  
Beer Industry ◽  
Spent Grain ◽  
Inhibitory Activities

New peptides with cholesterol esterase and pancreatic lipase inhibitory activities were identified from brewer's spent grain hydrolysate, providing added value to this by-product obtained from the beer industry.

scholarly journals New Biflavonoids with α-Glucosidase and Pancreatic Lipase Inhibitory Activities from Boesenbergia rotunda

Molecules ◽  
2017 ◽  
Vol 22 (11) ◽  
pp. 1862 ◽  
Author(s):  
Nutputsorn Chatsumpun ◽  
Boonchoo Sritularak ◽  
Kittisak Likhitwitayawuid
Keyword(s):  
Pancreatic Lipase ◽  
Inhibitory Activities ◽  
Boesenbergia Rotunda

scholarly journals Inhibitory Activities of Polyphenolic Extracts of Bangladeshi Vegetables against α-Amylase, α-Glucosidase, Pancreatic Lipase, Renin, and Angiotensin-Converting Enzyme

Foods ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 844
Author(s):  
Razia Sultana ◽  
Adeola M. Alashi ◽  
Khaleda Islam ◽  
Md Saifullah ◽  
C. Emdad Haque ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Inhibitory Activity ◽  
The Other ◽  
Converting Enzyme ◽  
Inhibitory Activities ◽  
Ash Gourd ◽  
Better Than

The aim of the study was to determine the in vitro enzyme inhibition activities of aqueous polyphenolic extracts of nine popular Bangladeshi vegetables, namely ash gourd, bitter gourd, brinjal, Indian spinach, kangkong, okra, ridge gourd, snake gourd, and stem amaranth. Polyphenolic glycosides were the major compounds present in the extracts. Inhibition of α-amylase (up to 100% at 1 mg/mL) was stronger than α-glucosidase inhibition (up to 70.78% at 10 mg/mL). The Indian spinach extract was the strongest inhibitor of pancreatic lipase activity (IC50 = 276.77 µg/mL), which was significantly better than that of orlistat (381.16 µg/mL), a drug. Ash gourd (76.51%), brinjal (72.48%), and snake gourd (66.82%) extracts were the most effective inhibitors of angiotensin-converting enzyme (ACE), an enzyme whose excessive activities have been associated with hypertension. Brinjal also had a significantly higher renin-inhibitory activity than the other vegetable extracts. We conclude that the vegetable extracts may have the ability to reduce enzyme activities that have been associated with hyperglycemia, hyperlipidemia, and hypertension.

Epipremnum pinnatum Activity on Chick Pancreatic Lipase

2015 ◽  
Vol 1113 ◽  
pp. 182-186 ◽  
Author(s):  
Fazlena Hamzah ◽  
Fatin Hafizah binti Mohd Yusop ◽  
Shareena Fairuz Abdul Manaf ◽  
Asdarina Yahya
Keyword(s):  
Pancreatic Lipase ◽  
Lipase Activity ◽  
Scientific Data ◽  
Tropical Country ◽  
Chromatography Analysis ◽  
Climbing Plant ◽  
Gas Chromatography Analysis ◽  
Phenolic Components ◽  
Inhibitory Activities ◽  
Folk Remedies

Epipremnum pinnatum is a vegetative, type of vines and climbing plant that can be found in a semitropical and tropical country in South East Asia and Asian region. It has been used as folk remedies due to its medicinal properties and capability in enhancing the immune system. However, limited scientific data are present to support this claim. Thus, the present study was focused on the determination of phytochemical properties of the extract E. pinnatum and the effect on the pancreatic lipase inhibitory activities. Phytochemical of E. pinnatum was extracted using supercritical carbon dioxide (CO2) at 6000 psi and 40°C. The extracted oil was analyzed using Follin- Ciocalteu method to determine the phenolic components and followed by gas chromatography analysis. Chicken pancreas was used to investigate pancreatic lipase inhibitory activities of the extracted E.pinnatum. The results indicated that extract E.pinnatum could inhibit the chicken pancreatic lipase activity and based on the analysis obtained, the amount of lipase activity inhibited was 74 % by using 48 μg/ml of extract E.pinnatum.

scholarly journals α-Glucosidase and pancreatic lipase inhibitory activities and glucose uptake stimulatory effect of phenolic compounds from Dendrobium formosum

2017 ◽  
Vol 27 (4) ◽  
pp. 480-487 ◽  
Author(s):  
Prachyaporn Inthongkaew ◽  
Nutputsorn Chatsumpun ◽  
Chonlakan Supasuteekul ◽  
Tharita Kitisripanya ◽  
Waraporn Putalun ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Glucose Uptake ◽  
Pancreatic Lipase ◽  
Inhibitory Activities
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