Combination of Ph3P and I2 with an appropriate reagent addition sequence could enable effective amidation of carboxylic acids with tertiary amines under mild conditions.
The oxidative radical decarboxylation of carboxylic acids with TEMPO as radical scavenger in a biphasic solvent system is reported which is successfully used in a new synthetic approach for the antidepressants indatraline.
A metal-free photoredox catalyzed decarboxylative radical coupling of free-carboxylic acids and glyoxylic oximes was developed to synthesize α,β-diamino acids.