ChemInform Abstract: Broensted Acid Catalyzed [3 + 2]-Cycloaddition of 2-Vinylindoles with in situ Generated 2-Methide-2H-indoles: Highly Enantioselective Synthesis of Pyrrolo[1,2-a]indoles.

ChemInform ◽  
2016 ◽  
Vol 47 (40) ◽  
Author(s):  
Kalisankar Bera ◽  
Christoph Schneider
Keyword(s):  
Enantioselective Synthesis ◽  
Acid Catalyzed

scholarly journals Chiral Brønsted acid-catalyzed Friedel–Crafts alkylation of electron-rich arenes with in situ-generated ortho-quinone methides: highly enantioselective synthesis of diarylindolylmethanes and triarylmethanes

2015 ◽  
Vol 51 (8) ◽  
pp. 1461-1464 ◽  
Author(s):  
Satyajit Saha ◽  
Santosh Kumar Alamsetti ◽  
Christoph Schneider
Keyword(s):  
Enantioselective Synthesis ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Quinone Methides ◽  
Reaction Conditions ◽  
Brönsted Acid ◽  
Acid Catalyzed ◽  
Chiral Bronsted Acid ◽  
Hydrogen Bonded

Hydrogen-bonded, in situ-generated ortho-quinone methides undergo highly enantioselective Friedel–Crafts reactions with indoles and naphthols under mild reaction conditions.

Brønsted acid-catalyzed, enantioselective synthesis of 1,4-dihydroquinoline-3-carboxylates via in situ generated ortho-quinone methide imines

2017 ◽  
Vol 15 (17) ◽  
pp. 3706-3716 ◽  
Author(s):  
Tomáš Hodík ◽  
Christoph Schneider
Keyword(s):  
Phosphoric Acid ◽  
Acid Catalysis ◽  
Nitrogen Heterocycles ◽  
Enantioselective Synthesis ◽  
Quinone Methide ◽  
Keto Esters ◽  
Brönsted Acid ◽  
Acid Catalyzed ◽  
Straightforward Approach

A straightforward approach toward the synthesis of a broad range of 1,4-dihydroquinoline-3-carboxylates is described. Under phosphoric acid catalysis in situ-generated ortho-quinone methide imines reacted with β-keto esters to form the nitrogen heterocycles with good chemical yields and enantioselectivities.

Chiral Brønsted acid-catalysed enantioselective synthesis of isoindolinone-derived N(acyl),S-acetals

2016 ◽  
Vol 52 (10) ◽  
pp. 2071-2074 ◽  
Author(s):  
Josipa Suć ◽  
Irena Dokli ◽  
Matija Gredičak
Keyword(s):  
Enantioselective Synthesis ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Brönsted Acid ◽  
Acid Catalyzed ◽  
Chiral Bronsted Acid ◽  
High Yields

Chiral Brønsted acid catalyzed synthesis of N(acyl),S-acetals from in situ generated ketimines proceeds in high yields and enantioselectivities.

Enantioselective Synthesis of Difluoroalkylated Isoindolinones via Chiral Spirocyclic Phosphoric Acid Catalyzed Mannich-Type Reaction

Synlett ◽  
2020 ◽  
Author(s):  
Xufeng Lin ◽  
Lei Wang ◽  
Jialing Zhong
Keyword(s):  
Phosphoric Acid ◽  
Enantioselective Synthesis ◽  
Type Reaction ◽  
Acid Catalyzed ◽  
High Yields ◽  
Stereogenic Center ◽  
Facile Route

AbstractAn enantioselective Mannich-type reaction of in situ generated cyclic ketimines with difluoroenoxysilanes catalyzed by chiral spirocyclic phosphoric acid has been developed. This methodology provides a facile route to difluoroalkyl-substituted chiral isoindolinones bearing a quaternary stereogenic center in high yields and up to 96% enantioselectivity.

Sign in / Sign up

Export Citation Format

Share Document