ChemInform Abstract: Zika Virus Drug Targets: A Missing Link in Drug Design and Discovery - A Route Map to Fill the Gap

ChemInform ◽  
2016 ◽  
Vol 47 (39) ◽  
Author(s):  
Pritika Ramharack ◽  
Mahmoud E. S. Soliman
Keyword(s):  
Drug Design ◽  
Zika Virus ◽  
Drug Targets ◽  
Missing Link

Zika virus drug targets: a missing link in drug design and discovery – a route map to fill the gap

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 68719-68731 ◽  
Author(s):  
Pritika Ramharack ◽  
Mahmoud E. S. Soliman
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Viral Replication ◽  
Zika Virus ◽  
In Silico ◽  
Drug Targets ◽  
Missing Link ◽  
Potential Inhibitors

This review depicts anin silicoroute map for ZIKV drug discovery, thus revealing novel potential inhibitors of viral replication.

Recent Advances towards Drug Design Targeting the Protease of 2019 novel coronavirus (2019-nCoV)

2020 ◽  
Vol 27 ◽  
Author(s):  
Sehrish Bano ◽  
Abdul Hameed ◽  
Mariya Al-Rashida ◽  
Shafia Iftikhar ◽  
Jamshed Iqbal
Keyword(s):  
Drug Design ◽  
Rna Polymerase ◽  
Drug Targets ◽  
Antiviral Agents ◽  
Structural Features ◽  
Antiviral Drugs ◽  
Rna Dependent Rna Polymerase ◽  
Mortality And Morbidity ◽  
Functional Relationships ◽  
Novel Coronavirus

Background: The 2019 novel coronavirus (2019-nCoV), also known as coronavirus 2 (SARS-CoV-2) acute respiratory syndrome has recently emerged and continued to spread rapidly with high level of mortality and morbidity rates. Currently, no efficacious therapy is available to relieve coronavirus infections. As new drug design and development takes much time, there is a possibility to find an effective treatment from existing antiviral agents. Objective: In this case, there is a need to find out the relationship between possible drug targets and mechanism of action of antiviral drugs. This review discusses about the efforts to develop drug from known or new molecules. Methods: Viruses usually have two structural integrities, proteins and nucleic acids, both of which can be possible drug targets. Herein, we systemically discuss the structural-functional relationships of the spike, 3-chymotrypsin-like protease (3CLpro), papain like protease (PLpro) and RNA-dependent RNA polymerase (RdRp), as these are prominent structural features of corona virus. Certain antiviral drugs such as Remdesivir are RNA dependent RNA polymerase inhibitor. It has the ability to terminate RNA replication by inhibiting ATP. Results: It is reported that ATP is involved in synthesis of coronavirus non-structural proteins from 3CLpro and PLpro. Similarly, mechanisms of action of many other antiviral agents has been discussed in this review. It will provide new insights into the mechanism of inhibition, and let us develop new therapeutic antiviral approaches against novel SARS-CoV-2 coronavirus. Conclusion: In conclusion, this review summarizes recent progress in developing protease inhibitors for SARS-CoV-2.

Phytochemicals for drug discovery in Alzheimer’s disease: In silico Advances

2020 ◽  
Vol 26 ◽  
Author(s):  
Smriti Sharma ◽  
Vinayak Bhatia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Design ◽  
In Silico ◽  
Drug Targets ◽  
Development Process ◽  
Phytochemical Analysis ◽  
Computational Drug Design ◽  
Novel Drugs ◽  
Game Changer

: The search for novel drugs that can prevent or control Alzheimer’s disease has attracted lot of attention from researchers across the globe. Phytochemicals are increasingly being used to provide scaffolds to design drugs for AD. In silico techniques, have proven to be a game-changer in this drug design and development process. In this review, the authors have focussed on current advances in the field of in silico medicine, applied to phytochemicals, to discover novel drugs to prevent or cure AD. After giving a brief context of the etiology and available drug targets for AD, authors have discussed the latest advances and techniques in computational drug design of AD from phytochemicals. Some of the prototypical studies in this area are discussed in detail. In silico phytochemical analysis is a tool of choice for researchers all across the globe and helps integrate chemical biology with drug design.

The missing link between clinical endpoints and drug targets in depression

2010 ◽  
Vol 31 (4) ◽  
pp. 144-152 ◽  
Author(s):  
Oscar Della Pasqua ◽  
Gijs W. Santen ◽  
Meindert Danhof
Keyword(s):  
Drug Targets ◽  
Missing Link ◽  
Clinical Endpoints

scholarly journals Structure and function of Zika virus NS5 protein: perspectives for drug design

2018 ◽  
Vol 75 (10) ◽  
pp. 1723-1736 ◽  
Author(s):  
Boxiao Wang ◽  
Stephanie Thurmond ◽  
Rong Hai ◽  
Jikui Song
Keyword(s):  
Drug Design ◽  
Zika Virus ◽  
Structure And Function ◽  
And Function

scholarly journals Novel method to identify group-specific non-catalytic pockets of human kinome for drug design

RSC Advances ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 2004-2015 ◽  
Author(s):  
Huiwen Wang ◽  
Zeyu Guan ◽  
Jiadi Qiu ◽  
Ya Jia ◽  
Chen Zeng ◽  
...  
Keyword(s):  
Drug Design ◽  
Drug Targets ◽  
Hybrid Approach ◽  
Biological Pathways ◽  
Novel Method ◽  
Human Kinome

Kinase proteins have been intensively investigated as drug targets for decades because of their crucial involvement in many biological pathways. We developed hybrid approach to identify non-catalytic pockets and will benefit the kinome drug design.

Computer-Aided Drug Design for NS5 Protein of Zika Virus

2017 ◽  
Vol 179 (8) ◽  
pp. 19-23
Author(s):  
Jayasree Ganugapati ◽  
Vaishnavi Tammara ◽  
Mary Nikitha ◽  
M. Shaistha
Keyword(s):  
Drug Design ◽  
Zika Virus ◽  
Computer Aided Drug Design ◽  
Computer Aided
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