ChemInform Abstract: Atom-Economic Dehydrogenative Amide Synthesis via Ruthenium Catalysis

ChemInform ◽  
2016 ◽  
Vol 47 (31) ◽  
Author(s):  
Cheng Chen ◽  
Francis Verpoort ◽  
Qiongyou Wu
Keyword(s):  
Amide Synthesis ◽  
Ruthenium Catalysis

Atom-economic dehydrogenative amide synthesis via ruthenium catalysis

RSC Advances ◽  
2016 ◽  
Vol 6 (60) ◽  
pp. 55599-55607 ◽  
Author(s):  
Cheng Chen ◽  
Francis Verpoort ◽  
Qiongyou Wu
Keyword(s):  
Amide Synthesis ◽  
Economic Transformations ◽  
Recent Developments ◽  
Ruthenium Catalysis

Recent developments of ruthenium-catalyzed atom-economic transformations for dehydrogenative amide synthesis are reviewed.

scholarly journals Discovery, characterization and engineering of ligases for amide synthesis

Nature ◽  
2021 ◽  
Vol 593 (7859) ◽  
pp. 391-398
Author(s):  
Michael Winn ◽  
Michael Rowlinson ◽  
Fanghua Wang ◽  
Luis Bering ◽  
Daniel Francis ◽  
...  
Keyword(s):  
Amide Synthesis

Remote C–H Functionalizations by Ruthenium Catalysis

Synthesis ◽  
2021 ◽  
Author(s):  
Korkit Korvorapun ◽  
Ramesh C. Samanta ◽  
Torben Rogge ◽  
Lutz Ackermann
Keyword(s):  
Steric Hindrance ◽  
Late Stage ◽  
Crop Protection ◽  
Full Control ◽  
Site Selectivity ◽  
Important Approach ◽  
Distinct Character ◽  
Ruthenium Catalysis ◽  
Material Sciences ◽  
Site Selective

Synthetic transformations of otherwise inert C–H bonds have emerged as a powerful tool for molecular modifications during the last decades, with broad applications towards pharmaceuticals, material sciences and crop protection. Consistently, a key challenge in C–H activation chemistry is the full control of site-selectivity. In addition to substrate control through steric hindrance or kinetic acidity of C–H bonds, one important approach for the site-selective C–H transformation of arenes is the use of chelation-assistance through directing groups, therefore leading to proximity-induced ortho-C–H metalation. In contrast, more challenging remote C–H activations at the meta- or para-positions continue to be scarce. Within this review, we demonstrate the distinct character of ruthenium catalysis for remote C–H activations until March 2021, highlighting among others late-stage modifications of bio-relevant molecules. Moreover, we highlight important mechanistic insights by experiments and computation, highlighting the key importance of carboxylate-assisted C–H activation with ruthenium(II) complexes.

Amide Synthesis from Alcohols and Amines Catalyzed by Ruthenium N-Heterocyclic Carbene Complexes

2010 ◽  
Vol 16 (23) ◽  
pp. 6820-6827 ◽  
Author(s):  
Johan Hygum Dam ◽  
Gyorgyi Osztrovszky ◽  
Lars Ulrik Nordstrøm ◽  
Robert Madsen
Keyword(s):  
Carbene Complexes ◽  
Amide Synthesis

scholarly journals Assembly of Four Diverse Heterocyclic Libraries Enabled by Prins Cyclization, Au-Catalyzed Enyne Cycloisomerization, and Automated Amide Synthesis

2012 ◽  
Vol 77 (17) ◽  
pp. 7435-7470 ◽  
Author(s):  
Jiayue Cui ◽  
David I. Chai ◽  
Christopher Miller ◽  
Jason Hao ◽  
Christopher Thomas ◽  
...  
Keyword(s):  
Prins Cyclization ◽  
Amide Synthesis

Rethinking the Dehydrogenative Amide Synthesis

ACS Catalysis ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. 6656-6662 ◽  
Author(s):  
Dmitry G. Gusev
Keyword(s):  
Amide Synthesis
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