ChemInform Abstract: Efficient Synthesis of β-Lactam Containing α-Hydroxy Phosphonates Using Tartaric Acid and Fumaric Acid as Mild Catalysts.

ChemInform ◽  
2016 ◽  
Vol 47 (30) ◽  
Author(s):  
Vijaya Bhaskar Vangala ◽  
Hari N. Pati
Keyword(s):  
Tartaric Acid ◽  
Fumaric Acid ◽  
Efficient Synthesis ◽  
Hydroxy Phosphonates

Simultaneous Gas Chromatographic Determination of Carboxylic Acids in Soft Drinks and Jams

1985 ◽  
Vol 68 (5) ◽  
pp. 902-905
Author(s):  
Taizo Tsuda ◽  
Hiroshi Nakanishi ◽  
Takashi Morita ◽  
Junko Takebayashi
Keyword(s):  
Benzoic Acid ◽  
Succinic Acid ◽  
Tartaric Acid ◽  
Carboxylic Acids ◽  
Fumaric Acid ◽  
Malic Acid ◽  
Sorbic Acid ◽  
Chromatographic Determination ◽  
Dehydroacetic Acid

Abstract A method was developed for simultaneous gas chromatographic determination of sorbic acid, dehydroacetic acid, and benzoic acid used as preservatives, and succinic acid, fumaric acid, malic acid, and tartaric acid used as acidulants in soft drinks and jams. A sample was dissolved in NH4OH-NH4CI pH 9 buffer solution, and an aliquot of the solution was passed through a QAE-Sephadex A 25 column. The column was washed with water, and the carboxylic acids were eluted with 0.1N HC1. Sorbic acid, dehydroacetic acid, and benzoic acid were extracted with ethyl ether-petroleum ether (1 + 1), and determined on a 5% DEGS + 1% H3PO4 column. Succinic acid, fumaric acid, malic acid, and tartaric acid in the lower layer were derivatized with N,0- bis(trimethylsilyl)acetamide and trimethylchlorosilane, and determined on a 3% SE-30 column. Recoveries from soft drink and jam samples fortified with 0.1% each of 7 carboxylic acids ranged from 92.4 to 102.6% for preservatives, and from 88.1 to 103.2% for acidulants.

ChemInform Abstract: Highly Efficient Synthesis of Quaternary α-Hydroxy Phosphonates via Lewis Acid Catalyzed Hydrophosphonylation of Ketones.

ChemInform ◽  
2010 ◽  
Vol 41 (11) ◽  
pp. no-no
Author(s):  
Xin Zhou ◽  
Yanling Liu ◽  
Lu Chang ◽  
Jiannan Zhao ◽  
Deju Shang ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
Hydroxy Phosphonates ◽  
Acid Catalyzed

scholarly journals BX795-Organic Acid Coevaporates: Evaluation of Solid-State Characteristics, In Vitro Cytocompatibility and In Vitro Activity against HSV-1 and HSV-2

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1920
Author(s):  
Yogesh Sutar ◽  
Tejabhiram Yadavalli ◽  
Sagar Kumar Paul ◽  
Sudipta Mallick ◽  
Raghuram Koganti ◽  
...  
Keyword(s):  
Citric Acid ◽  
Antiviral Activity ◽  
Organic Acids ◽  
Organic Acid ◽  
Tartaric Acid ◽  
Fumaric Acid ◽  
Amorphous Systems ◽  
Amorphous System ◽  
Hsv 1

BX795 is a TANK binding kinase-1 inhibitor that has shown excellent therapeutic activity in murine models of genital and ocular herpes infections on topical delivery. Currently, only the BX795 free base and its hydrochloride salt are available commercially. Here, we evaluate the ability of various organic acids suitable for vaginal and/or ocular delivery to form BX795 salts/cocrystals/co-amorphous systems with the aim of facilitating pharmaceutical development of BX795. We characterized BX795-organic acid coevaporates using powder X-ray diffractometry, Fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, 1H-nuclear magnetic resonance spectroscopy, thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) to elucidate the interaction between BX795 and various organic acids such as taurine, maleic acid, fumaric acid, tartaric acid, and citric acid. Furthermore, using human corneal epithelial cells and HeLa cells, we evaluated BX795-organic acid coevaporates for in vitro cytocompatibility and in vitro antiviral activity against herpes simplex virus-type 1 (HSV-1) and type-2 (HSV-2). Our studies indicate that BX795 forms co-amorphous systems with tartaric acid and citric acid. Interestingly, the association of organic acids with BX795 improved its thermal stability. Our in vitro cytocompatibility and in vitro antiviral studies to screen suitable BX795-organic acid coevaporates for further development show that all BX795-organic acid systems, at a concentration equivalent to 10 µM BX795, retained antiviral activity against HSV-1 and HSV-2 but showed differential cytocompatibility. Further, dose-dependent in vitro cytocompatibility and antiviral activity studies on the BX795-fumaric acid system, BX795-tartaric acid co-amorphous system, and BX795-citric acid co-amorphous system show similar antiviral activity against HSV-1 and HSV-2 compared to BX795, whereas only the BX795-citric acid co-amorphous system showed higher in vitro cytocompatibility compared to BX795.

scholarly journals Preparation of polyaniline nanostructures doped with different dicarboxylic acids through template-free method

2014 ◽  
Vol 32 (3) ◽  
pp. 419-422
Author(s):  
Chuanyu Sun ◽  
Yu Wang
Keyword(s):  
Dicarboxylic Acid ◽  
Succinic Acid ◽  
Tartaric Acid ◽  
Fumaric Acid ◽  
Maleic Acid ◽  
Dicarboxylic Acids ◽  
Template Free ◽  
Acid Dopants

AbstractIn this article nanoscaled polyanilines (PANI) were prepared based on template-free method in the presence of dicarboxylic acid dopants (e.g. D-tartaric acid, succinic acid, maleic acid and fumaric acid). The trans-cis isomerization of butenedioic acid played an important role in the formation of nanostructures from the plane-like to nanofibers, and the PANI doped with maleic acid (MA) had larger diameter, higher crystallinity and conductivity than PANI doped with fumaric acid (FA).

An efficient synthesis of α-hydroxy phosphonates and 2-nitroalkanols using Ba(OH)2 as catalyst

2012 ◽  
Vol 441-442 ◽  
pp. 119-123 ◽  
Author(s):  
Muthupandi Pandi ◽  
Prem Kumar Chanani ◽  
Sekar Govindasamy
Keyword(s):  
Efficient Synthesis ◽  
Hydroxy Phosphonates

Nanoscaled Polyaniline Doped with Different Dicarboxylic Acids Based On Template-Free Method

2011 ◽  
Vol 239-242 ◽  
pp. 219-222 ◽  
Author(s):  
Shao Jin Jia ◽  
Zhen Liu ◽  
Ping Kai Jiang ◽  
Jian Zhou
Keyword(s):  
Succinic Acid ◽  
Tartaric Acid ◽  
Fumaric Acid ◽  
Maleic Acid ◽  
Dicarboxylic Acids ◽  
Average Diameter ◽  
Template Free

With an average diameter of 148-285 nm and a conductivity of 2.38E-2- 5.88 E-2S/cm, Nanoscaled polyaniline (PANI) were synthesized based on template-free method in the presence of dicarboxylic acids dopants (e.g., D-tartaric acid, Succinic acid, maleic acid and fumaric acid). Furthermore, the trans-cis isomerization of butenedioic acid plays an important role in the formation of nanostructures from plane-like to nanofibers, and PANI-MA has larger diameter, higher crystallinity and conductivity than PANI-FA.

scholarly journals Molecular Crystal Forms of Antitubercular Ethionamide with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 818
Author(s):  
Simone Bordignon ◽  
Paolo Cerreia Vioglio ◽  
Elena Amadio ◽  
Federica Rossi ◽  
Emanuele Priola ◽  
...  
Keyword(s):  
Solid State ◽  
Tartaric Acid ◽  
Fumaric Acid ◽  
Dicarboxylic Acids ◽  
Active Pharmaceutical Ingredient ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Multicomponent Systems ◽  
Crystal Forms

We report on the preparation, characterization, and bioavailability properties of three new crystal forms of ethionamide, an antitubercular agent used in the treatment of drug-resistant tuberculosis. The new adducts were obtained by combining the active pharmaceutical ingredient with three dicarboxylic acids, namely glutaric, malonic and tartaric acid, in equimolar ratios. Crystal structures were obtained for all three adducts and were compared with two previously reported multicomponent systems of ethionamide with maleic and fumaric acid. The ethionamide-glutaric acid and the ethionamide-malonic acid adducts were thoroughly characterized by means of solid-state NMR (13C and 15N Cross-Polarization Magic Angle Spinning or CPMAS) to confirm the position of the carboxylic proton, and they were found to be a cocrystal and a salt, respectively; they were compared with two previously reported multicomponent systems of ethionamide with maleic and fumaric acid. Ethionamide-tartaric acid was found to be a rare example of kryptoracemic cocrystal. In vitro bioavailability enhancements up to a factor 3 compared to pure ethionamide were assessed for all obtained adducts.

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