ChemInform Abstract: Potassium Carbonate-Mediated Tandem C-S and C-N Coupling Reaction for the Synthesis of Phenothiazines under Transition-Metal-Free and Ligand-Free Conditions.

ChemInform ◽  
2016 ◽  
Vol 47 (29) ◽  
Author(s):  
San Wu ◽  
Wei-Ye Hu ◽  
Song-Lin Zhang
Keyword(s):  
Transition Metal ◽  
Potassium Carbonate ◽  
Coupling Reaction ◽  
Metal Free ◽  
Ligand Free

Potassium carbonate-mediated tandem C–S and C–N coupling reaction for the synthesis of phenothiazines under transition-metal-free and ligand-free conditions

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24257-24260 ◽  
Author(s):  
San Wu ◽  
Wei-Ye Hu ◽  
Song-Lin Zhang
Keyword(s):  
Transition Metal ◽  
Potassium Carbonate ◽  
Coupling Reaction ◽  
Metal Catalyst ◽  
Phenothiazine Derivatives ◽  
Transition Metal Catalyst ◽  
Metal Free ◽  
Efficient Approach ◽  
Ligand Free

A potassium carbonate-mediated tandem coupling reaction for the synthesis of phenothiazines is described. This protocol affords an efficient approach for the construction of phenothiazine derivatives without the need for addition of transition-metal catalyst or ligand.

Transition-metal-free radical cleavage of a hydrazonyl N–S bond: tosyl radical-initiated cascade C(sp3)–OAr cleavage, sulfonyl rearrangement and atropisomeric cyclopropanation

2018 ◽  
Vol 5 (24) ◽  
pp. 3567-3573 ◽  
Author(s):  
Yao-Zhong Chen ◽  
Teng Liu ◽  
Jie Zhu ◽  
Hui Zhang ◽  
Lei Wu
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Potassium Carbonate ◽  
Coupling Reaction ◽  
Metal Free ◽  
Radical Cleavage

Combination of 1,10-phenanthroline and potassium carbonate enables a radical cleavage of a hydrazonyl N–S bond, allowing a coupling reaction of N-tosylhydrazone and phosphinyl allene via cascade C–O cleavage, sulfonyl rearrangement and atropisomeric cyclopropanation.

Transition metal free intramolecular selective oxidative C(sp3)–N coupling: synthesis of N-aryl-isoindolinones from 2-alkylbenzamides

2015 ◽  
Vol 51 (7) ◽  
pp. 1371-1374 ◽  
Author(s):  
Ajay Verma ◽  
Saket Patel ◽  
Meenakshi Meenakshi ◽  
Amit Kumar ◽  
Abhimanyu Yadav ◽  
...  
Keyword(s):  
Transition Metal ◽  
Potassium Carbonate ◽  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Metal Free ◽  
Oxidative Coupling Reaction ◽  
Butyl Peroxide

A transition metal-free intramolecular selective oxidative coupling reaction of C(sp3)–H and N–H bonds has been presented utilizing iodine, potassium carbonate and di-tert-butyl peroxide in acetonitrile at 110–140 °C.

ChemInform Abstract: A Transition-Metal-Free Cross-Coupling Reaction of Allylic Bromides with Aryl- and Vinylboronic Acids.

ChemInform ◽  
2012 ◽  
Vol 43 (33) ◽  
pp. no-no
Author(s):  
Mitsuhiro Ueda ◽  
Kota Nishimura ◽  
Ryo Kashima ◽  
Ilhyong Ryu
Keyword(s):  
Transition Metal ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Metal Free ◽  
Cross Coupling Reaction

scholarly journals K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2225 ◽  
Author(s):  
Yongjun Bian ◽  
Xingyu Qu ◽  
Yongqiang Chen ◽  
Jun Li ◽  
Leng Liu
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Sulfur Atom ◽  
Coupling Reaction ◽  
Sulfur Source ◽  
Atom Transfer ◽  
Free Condition ◽  
Metal Free ◽  
Aryl Aldehydes ◽  
Three Component Coupling

Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.

Transition metal-free tandem pyridinyl–allyl–allyl cross-coupling reaction

2017 ◽  
Vol 47 (18) ◽  
pp. 1668-1675 ◽  
Author(s):  
Lili Zhang ◽  
Zhengkai Chen ◽  
Hongli Li ◽  
Wenguang Yin ◽  
Jianfeng Xu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Metal Free ◽  
Cross Coupling Reaction

scholarly journals Retraction: Transition-metal-free synthesis of conjugated microporous polymers via amine-catalyzed Suzuki–Miyaura coupling reaction

2021 ◽  
Author(s):  
Qingmin Liu ◽  
Shangbin Jin ◽  
Bien Tan
Keyword(s):  
Transition Metal ◽  
Coupling Reaction ◽  
Metal Free ◽  
Microporous Polymers ◽  
Conjugated Microporous Polymers

Retraction of ‘Transition-metal-free synthesis of conjugated microporous polymers via amine-catalyzed Suzuki–Miyaura coupling reaction’ by Qingmin Liu et al., Chem. Sci., 2021, DOI: 10.1039/d1sc03970a.

An Iodide-Mediated Transition-Metal-Free Strategy towards Unsymmetrical Diaryl Sulfides via Arylhydrazines and Thiols

Synthesis ◽  
2019 ◽  
Vol 52 (05) ◽  
pp. 727-734 ◽  
Author(s):  
Farnaz Jafarpour ◽  
Mohammad Asadpour ◽  
Meysam Azizzade ◽  
Mehran Ghasemi ◽  
Saideh Rajai-Daryasarei
Keyword(s):  
Transition Metal ◽  
Room Temperature ◽  
Bond Formation ◽  
Antidepressant Drug ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Potential Utility ◽  
Metal Free ◽  
Cross Coupling Reaction ◽  
High Yields

A mild, scalable iodine-mediated oxidative cross-coupling reaction of arylhydrazines and thiols for construction of thioethers (sulfides) in the absence of any transition metals or photocatalysts is disclosed. A variety of unsymmetrical diaryl sulfides with broad substrate scope both on thiols and hydrazines were synthesized in high yields in water at room temperature. Furthermore, to demonstrate the utility of the protocol, the above C–S bond formation was applied in the synthesis of the key structure of vortioxetine as an antidepressant drug. The gram-scale outcome also added to the potential utility of this protocol.

(Diacetoxyiodo)benzene-Mediated Transition-Metal-Free Amination of C(sp3)–H Bonds Adjacent to Heteroatoms with Azoles: Synthesis of N-Alkylated Azoles

Synlett ◽  
2018 ◽  
Vol 29 (18) ◽  
pp. 2432-2436 ◽  
Author(s):  
Can Jin ◽  
Weike Su ◽  
Bin Sun ◽  
Zhiyang Yan
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Coupling Reaction ◽  
Metal Catalyst ◽  
Metal Free ◽  
Alternative Method ◽  
Dehydrogenative Coupling ◽  
Wide Range ◽  
Ready Access

A novel PhI(OAc)2-mediated cross-dehydrogenative coupling reaction of α-C(sp3)–H bonds adjacent to a hetero atom with various azoles has been developed, which provides an alternative method for constructing C–N bonds with high atom efficiency. This new protocol requires no metal catalyst and it provides ready access to a wide range of N-alkylated azole derivatives in moderate to excellent yields by using commercially available PhI(OAc)2 as the sole oxidant. Furthermore, the method is effective on a gram scale, which highlights the practicality of this transformation. The result of radical-captured experiments indicated that the transformation might involve a free-radical pathway.

Sign in / Sign up

Export Citation Format

Share Document