ChemInform Abstract: A Novel One-Pot Method for the Synthesis of Pyrimidine Derivatives Using Ketene N,S-Acetal with Aryl Aldehydes.

ChemInform ◽  
2016 ◽  
Vol 47 (23) ◽  
Author(s):  
Masayori Hagimori ◽  
Yuka Murakami ◽  
Naoko Mizuyama ◽  
Yoshinori Tominaga
Keyword(s):  
Pyrimidine Derivatives ◽  
One Pot ◽  
Aryl Aldehydes

PTSA-Catalyzed One Pot Domino Synthesis of Dihydropyrido[2,3-d]pyrimidine Derivatives and their Antimicrobial Activity

2021 ◽  
Vol 6 (3) ◽  
pp. 222-227
Author(s):  
Krishna A. Bhensdadia ◽  
Prakash L. Kalavadiya ◽  
Nilam H. Lalavani ◽  
Shipra H. Baluja
Keyword(s):  
Antimicrobial Activity ◽  
Spectral Analysis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
In Vitro Antimicrobial Activity ◽  
Aryl Aldehydes ◽  
Three Component Reaction ◽  
The One

A novel series of dihydropyrido[2,3-d]pyrimidine derivatives were synthesized by multicomponent domino cyclization via the one-pot three component reaction of 6-amino uracil, substituted aryl aldehydes and N-methyl-1-(methylthio)-2-nitroethenamine in the presence of PTSA 10 mol% as a catalyst. The structures of these synthesized compounds were characterized by spectral analysis. Further the synthesized compounds screened for in vitro antimicrobial activity. Among all the compounds, compound 4b containing flouro substitution exhibited good inhibition against the tested species.

A Novel One-Pot Method for the Synthesis of Pyrimidine Derivatives Using Ketene N,S-Acetal with Aryl Aldehydes

2015 ◽  
Vol 53 (1) ◽  
pp. 197-201 ◽  
Author(s):  
Masayori Hagimori ◽  
Yuka Murakami ◽  
Naoko Mizuyama ◽  
Yoshinori Tominaga
Keyword(s):  
Pyrimidine Derivatives ◽  
One Pot ◽  
Aryl Aldehydes

scholarly journals Ultrasound-promoted synthesis of novel dihydropyrido[2,3-d:5,6- d`]dipyrimidine derivatives

2015 ◽  
Vol 11 (5) ◽  
pp. 3567-3575
Author(s):  
Manouchehr Mamaghani
Keyword(s):  
Acetic Acid ◽  
Glacial Acetic Acid ◽  
Mixed Solvent ◽  
Reaction Times ◽  
Efficient Synthesis ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Aryl Aldehydes ◽  
Three Component Reaction ◽  
High Yields

An efficient synthesis of dihydropyrido[2,3-d:5,6-d`]pyrimidine derivatives was developed via one-pot three-component reaction of 6-amino-2-(alkylthio)-pyrimidine-4(3H)one and aryl aldehydes in the mixed solvent of glacial acetic acid and DMF (1:1, v:v) under ultrasonic irradiation. In this protocol novel fused dihydropyrido[2,3-d]pyrimidines were synthesized in high yields (80-97%) and lower reaction times (5-25 min).

Solvent-free, one-pot synthesis of 2,4,6-triarylpyridines using trichloroisocyanuric acid or N-bromosuccinimide as a novel and neutral catalyst

2011 ◽  
Vol 76 (11) ◽  
pp. 1307-1315 ◽  
Author(s):  
Behrooz Maleki ◽  
Hafezeh Salehabadi ◽  
Zeinalabedin Sepehr ◽  
Mina Kermanian
Keyword(s):  
Ammonium Acetate ◽  
Solvent Free ◽  
One Pot ◽  
Aryl Aldehydes ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Trichloroisocyanuric Acid

A simple and benign protocol has been explored for the preparation of 2,4,6-triarylpyridines by a one-pot reaction between aryl aldehydes, enolizable ketones and ammonium acetate in the presence of N-bromosuccinimide or trichloroisocyanuric acid as green and neutral catalysts. The reactions proceed smoothly at 130 °C under solvent-free conditions to provide 2,4,6-triarylpyridines in good yields.

Three-Component, One-Pot Synthesis of Pyrido[2,3-d]pyrimidine Derivatives Catalyzed by KF-Alumina.

ChemInform ◽  
2005 ◽  
Vol 36 (49) ◽  
Author(s):  
Xiang-Shan Wang ◽  
Zhao-Sen Zeng ◽  
Da-Qing Shi ◽  
Shu-Jiang Tu ◽  
Xian-Yong Wei ◽  
...  
Keyword(s):  
Pyrimidine Derivatives ◽  
One Pot ◽  
One Pot Synthesis

Unexpected straightforward formation of trifluoromethylated pyrido[2,3- d ]pyrimidine derivatives via one-pot, MCRs

2017 ◽  
Vol 200 ◽  
pp. 162-168 ◽  
Author(s):  
Yang Wang ◽  
Lu Zhou ◽  
Yingjun Zhu ◽  
Min Zhang ◽  
Liping Song ◽  
...  
Keyword(s):  
Pyrimidine Derivatives ◽  
One Pot

scholarly journals NiO nanoparticles: A highly efficient catalyst for the one-pot three-component synthesis of pyrano [2, 3-d] pyrimidine derivatives in green media.

2021 ◽  
Vol 18 ◽  
Author(s):  
Ellahe Sabbaghnasab ◽  
Enayatollah Sheikhhosseini
Keyword(s):  
Barbituric Acid ◽  
Nio Nanoparticles ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Efficient Catalyst ◽  
Environmental Friendliness ◽  
Short Reaction Time ◽  
Pyrimidine Synthesis ◽  
Simple Processing ◽  
The One

: NiO nanoparticles are utilized to effectively strengthen annulated pyrano [2, 3- d] pyrimidine synthesis through primary Knoevenagel, following Micheal and ultimate heterocyclization reactions of aldehyde, malononitrile, and barbituric acid. The characteristics of NiO nanoparticles are identified using advanced techniques, such as IR, UV, EDX, XRD, SEM, and TEM. The nano-NiO particles are mostly below < 100 nm in size with uniform spherical shapes. The adopted approach is advantages thanks to its simple processing, relatively short reaction time, often good to high average yields, convenient workability, and environmental friendliness.

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