ChemInform Abstract: Self-Assembled DNA Nanostructures for Drug Delivery

ChemInform ◽  
2016 ◽  
Vol 47 (20) ◽  
Author(s):  
Ruokun Jia ◽  
Ting Wang ◽  
Qiao Jiang ◽  
Zhengang Wang ◽  
Chen Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dna Nanostructures ◽  
Self Assembled

Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures

2013 ◽  
Vol 25 (32) ◽  
pp. 4386-4396 ◽  
Author(s):  
Jiang Li ◽  
Chunhai Fan ◽  
Hao Pei ◽  
Jiye Shi ◽  
Qing Huang
Keyword(s):  
Drug Delivery ◽  
Dna Nanostructures ◽  
Self Assembled ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Chensheng Zhou ◽  
Heng Luo ◽  
Xiaolu Feng ◽  
Xingwang Li ◽  
Jie Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dna Sequences ◽  
Self Assembly ◽  
Web Server ◽  
Automatic Design ◽  
Dna Nanostructures ◽  
Complementary Dna ◽  
Dna Nanostructure ◽  
Comprehensive Information ◽  
Self Assembled

DNA self-assembly is a nanotechnology that folds DNA into desired shapes. Self-assembled DNA nanostructures, also known as origami, are increasingly valuable in nanomaterial and biosensing applications. Two ways to use DNA nanostructures in medicine are to form nanoarrays, and to work as vehicles in drug delivery. The DNA nanostructures perform well as a biomaterial in these areas because they have spatially addressable and size controllable properties. However, manually designing complementary DNA sequences for self-assembly is a technically demanding and time consuming task, which makes it advantageous for computers to do this job instead. We have developed a web server, FOLDNA, which can automatically design 2D self-assembled DNA nanostructures according to custom pictures and scaffold sequences provided by the users. It is the first web server to provide an entirely automatic design of self-assembled DNA nanostructure, and it takes merely a second to generate comprehensive information for molecular experiments including: scaffold DNA pathways, staple DNA directions, and staple DNA sequences. This program could save as much as several hours in the designing step for each DNA nanostructure. We randomly selected some shapes and corresponding outputs from our server and validated its performance in molecular experiments.

ChemInform Abstract: Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures

ChemInform ◽  
2013 ◽  
Vol 44 (46) ◽  
pp. no-no
Author(s):  
Jiang Li ◽  
Chunhai Fan ◽  
Hao Pei ◽  
Jiye Shi ◽  
Qing Huang
Keyword(s):  
Drug Delivery ◽  
Dna Nanostructures ◽  
Self Assembled ◽  
Smart Drug ◽  
Smart Drug Delivery

Self-Assembled DNA Nanostructures for Drug Delivery

2016 ◽  
Vol 34 (3) ◽  
pp. 265-272 ◽  
Author(s):  
Ruokun Jia ◽  
Ting Wang ◽  
Qiao Jiang ◽  
Zhengang Wang ◽  
Chen Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dna Nanostructures ◽  
Self Assembled

DNA Nanodevices: from Mechanical Motions to Biomedical Applications

2021 ◽  
Vol 21 ◽  
Author(s):  
Yiming Wang ◽  
Zhaoran Wang ◽  
Xiaohui Wu ◽  
Shaoli Liu ◽  
Fengsong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Deoxyribonucleic Acid ◽  
Molecular Machines ◽  
Dna Nanostructures ◽  
Spatial Accuracy ◽  
Recent Advances ◽  
Attractive Candidate ◽  
Self Assembled ◽  
Construction Strategies

: Inspired by molecular machines in nature, artificial nanodevices have been designed to realize various biomedical functions. Self-assembled deoxyribonucleic acid (DNA) nanostructures that feature designed geometries, excellent spatial accuracy, nanoscale addressability and marked biocompatibility provide an attractive candidate for constructing dynamic nanodevices with biomarker-targeting and stimuli-responsiveness for biomedical applications. Here, a summary of typical construction strategies of DNA nanodevices and their operating mechanisms are presented. We also introduced recent advances in employing DNA nanodevices as platforms for biosensing and intelligent drug delivery. Finally, the broad prospects and main challenges of the DNA nanodevices in biomedical applications are discussed.

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

Self-assembled drug delivery systems. Part 6: In vitro/in vivo studies of anticancer N-octadecanoyl gemcitabine nanoassemblies

2012 ◽  
Vol 430 (1-2) ◽  
pp. 276-281 ◽  
Author(s):  
Yiguang Jin ◽  
Yanju Lian ◽  
Lina Du ◽  
Shuangmiao Wang ◽  
Chang Su ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vivo Studies ◽  
Self Assembled

Thermo-responsive self-assembled polymeric micelles for drug delivery in vitro

2000 ◽  
Vol 205 (1-2) ◽  
pp. 165-172 ◽  
Author(s):  
In-Sook Kim ◽  
Young-Il Jeong ◽  
Chong-Su Cho ◽  
Sung-Ho Kim
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Self Assembled

Novel self-assembled pH-responsive biomimetic nanocarriers for drug delivery

2016 ◽  
Vol 64 ◽  
pp. 346-353 ◽  
Author(s):  
Minming Wu ◽  
Zhaoyu Cao ◽  
Yunfei Zhao ◽  
Rong Zeng ◽  
Mei Tu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Responsive ◽  
Self Assembled

Rapidly cell-penetrating and reductive milieu-responsive nanoaggregates assembled from an amphiphilic folate-camptothecin prodrug for enhanced drug delivery and controlled release

2017 ◽  
Vol 5 (3) ◽  
pp. 444-454 ◽  
Author(s):  
Zhigang Xu ◽  
Meili Hou ◽  
Xiaoxiao Shi ◽  
Yong-E. Gao ◽  
Peng Xue ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Folate Receptors ◽  
Tumour Detection ◽  
Cell Penetrating ◽  
Self Assembled

Self-assembled small molecular prodrug loaded with camptothecin in response to glutathione and folate receptors for combined tumour detection and treatment.

Sign in / Sign up

Export Citation Format

Share Document