ChemInform Abstract: Asymmetric Synthesis of Natural Products and Medicinal Drugs Through One-Pot-Reaction Strategies

ChemInform ◽  
2016 ◽  
Vol 47 (1) ◽  
Author(s):  
Bor-Cherng Hong ◽  
Arun Raja ◽  
Vishal M. Sheth
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
One Pot ◽  
Medicinal Drugs

Asymmetric Synthesis of Natural Products and Medicinal Drugs through One-Pot-Reaction Strategies

Synthesis ◽  
2015 ◽  
Vol 47 (21) ◽  
pp. 3257-3285 ◽  
Author(s):  
Bor-Cherng Hong ◽  
Arun Raja ◽  
Vishal Sheth
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
One Pot ◽  
Medicinal Drugs

scholarly journals Step economy in the Stereoselective Synthesis of Functionalized Oxindoles via Organocatalytic Domino/One-pot Reactions

2021 ◽  
Vol 25 ◽  
Author(s):  
Martina Bortolami ◽  
Francesca Leonelli ◽  
Marta Feroci ◽  
Fabrizio Vetica
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Bioactive Compounds ◽  
Stereoselective Synthesis ◽  
Environmentally Friendly ◽  
Important Class ◽  
One Pot ◽  
Asymmetric Organocatalysis ◽  
Toxic Approach

: Oxindoles are an important class of heterocyclic scaffolds widely present in natural products and bioactive compounds. For this reason, a plethora of methodologies for the stereoselective synthesis of enantioenriched oxindoles has been studied over the years. Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool for the asymmetric synthesis of this class of compounds being a step- and atom-economical, environmentally friendly, and non-toxic approach. This review will outline the application of asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on domino/one-pot reaction sequences in a step-economical fashion.

scholarly journals Multicomponent Domino Reaction in the Asymmetric Synthesis of Cyclopentan[c]pyran Core of Iridoid Natural Products

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1308
Author(s):  
Alejandro Manchado ◽  
Victoria Elena Ramos ◽  
David Díez ◽  
Narciso M. Garrido
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Asymmetric Synthesis ◽  
Heteronuclear Nmr ◽  
Domino Reaction ◽  
One Pot ◽  
Pharmaceutical Development ◽  
New Drug ◽  
Anti Inflammatory ◽  
Pharmaceutical Properties

The asymmetric synthesis of a compound with the cyclopentan[c]pyran core of iridoid natural products in four steps and 40% overall yield is reported. Our methodology includes a one-pot tandem domino reaction which provides a trisubstituted cyclopentane with five new completely determined stereocenters, which were determined through 2D homo and heteronuclear NMR and n.O.e. experiments on different compounds specially designed for this purpose, such as a dioxane obtained from a diol. Due to their pharmaceutical properties, including sedative, analgesic, anti-inflammatory, CNS depressor or anti-conceptive effects, this methodology to produce the abovementioned iridoid derivatives, is an interesting strategy in terms of new drug discovery as well as pharmaceutical development.

Indium Bromide-catalyzed Unprecedented Hydrogenolysis: A Novel One-Pot Synthesis of Per-O-Acetylated β-carboxymethyl O and S-glycosides

2020 ◽  
Vol 24 (8) ◽  
pp. 900-908
Author(s):  
Ram Naresh Yadav ◽  
Amrendra K Singh ◽  
Bimal Banik
Keyword(s):  
Asymmetric Synthesis ◽  
Chiral Auxiliary ◽  
Bioactive Molecules ◽  
One Pot ◽  
Enantiomerically Pure ◽  
Stereoselective Glycosylation ◽  
One Pot Synthesis ◽  
Wide Range

Numerous O (oxa)- and S (thia)-glycosyl esters and their analogous glycosyl acids have been accomplished through stereoselective glycosylation of various peracetylated bromo sugar with benzyl glycolate using InBr3 as a glycosyl promotor followed by in situ hydrogenolysis of resulting glycosyl ester. A tandem glycosylating and hydrogenolytic activity of InBr3 has been successfully investigated in a one-pot procedure. The resulting synthetically valuable and virtually unexplored class of β-CMGL (glycosyl acids) could serve as an excellent potential chiral auxiliary in the asymmetric synthesis of a wide range of enantiomerically pure medicinally prevalent β-lactams and other bioactive molecules of diverse medicinal interest.

Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis

ACS Catalysis ◽  
2013 ◽  
Vol 3 (12) ◽  
pp. 2856-2864 ◽  
Author(s):  
Carl A. Denard ◽  
John F. Hartwig ◽  
Huimin Zhao
Keyword(s):  
Asymmetric Synthesis ◽  
One Pot

ChemInform Abstract: Organocatalytic Asymmetric Synthesis of Chiral Nitrogenous Heterocycles and Natural Products

ChemInform ◽  
2015 ◽  
Vol 46 (7) ◽  
pp. no-no
Author(s):  
Jie Yu ◽  
Ya Zhou ◽  
Dian-Feng Chen ◽  
Liu-Zhu Gong
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis

Asymmetric synthesis of dihydrocarbazoles through Friedel-Crafts alkylation/annulation sequential reaction of indoles

2021 ◽  
Author(s):  
Linfeng Hu ◽  
Weidi Cao ◽  
Kaixuan Wang ◽  
Xiaohua Liu ◽  
Xiaoming Feng
Keyword(s):  
Asymmetric Synthesis ◽  
One Pot ◽  
Sequential Reaction

An enantioselective tandem Friedel-Crafts alkylation/annulation of indoles with diazoacetoacetate enones is realized in one pot. A series of dihydrocarbazoles were obtained in moderate yields with good to excellent ee values...

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