ChemInform Abstract: Enantioselective Small Molecule Synthesis by Carbon Dioxide Fixation Using a Dual Broensted Acid/Base Organocatalyst.

ChemInform ◽  
2015 ◽  
Vol 46 (41) ◽  
pp. no-no
Author(s):  
Brandon A. Vara ◽  
Thomas J. Struble ◽  
Weiwei Wang ◽  
Mark C. Dobish ◽  
Jeffrey N. Johnston
Keyword(s):  
Carbon Dioxide ◽  
Small Molecule ◽  
Carbon Dioxide Fixation ◽  
Acid Base ◽  
Small Molecule Synthesis

scholarly journals Enantioselective Small Molecule Synthesis by Carbon Dioxide Fixation using a Dual Brønsted Acid/Base Organocatalyst

2015 ◽  
Vol 137 (23) ◽  
pp. 7302-7305 ◽  
Author(s):  
Brandon A. Vara ◽  
Thomas J. Struble ◽  
Weiwei Wang ◽  
Mark C. Dobish ◽  
Jeffrey N. Johnston
Keyword(s):  
Carbon Dioxide ◽  
Small Molecule ◽  
Carbon Dioxide Fixation ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Acid Base ◽  
Brönsted Acid ◽  
Small Molecule Synthesis

scholarly journals CARBON DIOXIDE FIXATION IN ISOCITRIC ACID

1947 ◽  
Vol 170 (2) ◽  
pp. 461-465
Author(s):  
Santiago Grisolia ◽  
Birgit Vennesland
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Fixation ◽  
Isocitric Acid

scholarly journals THE PREPARATION OF C14-LABELED BIOTIN AND A STUDY OF ITS STABILITY DURING CARBON DIOXIDE FIXATION

1949 ◽  
Vol 180 (1) ◽  
pp. 299-305 ◽  
Author(s):  
Donald B. Melville ◽  
John G. Pierce ◽  
C.W.H. Partridge
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Fixation

scholarly journals BIOSYNTHESIS OF TRICARBOXYLIC ACIDS BY CARBON DIOXIDE FIXATION

1948 ◽  
Vol 174 (1) ◽  
pp. 123-132 ◽  
Author(s):  
Severo Ochoa ◽  
Erna Weisz-Tabori
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Fixation

scholarly journals Contrast‐enhanced ultrasound imaging can be used to evaluate fetal cerebral perfusion: potential implications for fetal surgery

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Kendall M. Lawrence ◽  
Barbara E. Coons ◽  
Anush Sridharan ◽  
Avery C. Rossidis ◽  
Marcus G. Davey ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Cerebral Perfusion ◽  
Fetal Surgery ◽  
Time Dependent ◽  
Contrast Enhanced Ultrasound ◽  
Acid Base ◽  
Fetal Sheep ◽  
Contrast Enhanced ◽  
Support Device ◽  
Acid Base Status

Abstract Background Fetal surgery is increasingly performed to correct congenital defects. Currently, fetal brain perfusion cannot be assessed intra-operatively. The purpose of this study was to determine if contrast-enhanced ultrasound (CEUS) could be used to monitor fetal cerebral perfusion during fetal surgery and if parameters correlate with fetal hemodynamics or acid/base status. Methods Cannulated fetal sheep were insufflated with carbon dioxide gas in an extra-uterine support device and in utero to mimic fetal surgery. Fetal heart rate, mean arterial pressure, and arterial blood gases were serially measured. CEUS examinations of the brain were performed and time-dependent metrics were quantified to evaluate perfusion. The relationships between measured parameters were determined with mixed linear effects models or two-way repeated measures analysis of variance. Results 6 fetal sheep (113 ± 5 days) insufflated at multiple time-points (n = 20 experiments) in an extra-uterine support device demonstrated significant correlations between time-dependent perfusion parameters and fetal pH and carbon dioxide levels. In utero, 4 insufflated fetuses (105 ± 1 days) developed hypercarbic acidosis and had reductions in cerebral perfusion parameters compared to age-matched controls (n = 3). There was no significant relationship between cerebral perfusion parameters and fetal hemodynamics. Conclusions CEUS-derived cerebral perfusion parameters can be measured during simulated fetal surgery and strongly correlate with fetal acid/base status.

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