ChemInform Abstract: Synthesis of Saturated Heterocycles via Metal-Catalyzed Allylic Alkylation Reactions

ChemInform ◽  
2015 ◽  
Vol 46 (33) ◽  
pp. no-no
Author(s):  
John M. Ketcham ◽  
Aaron Aponick
Keyword(s):  
Allylic Alkylation ◽  
Metal Catalyzed ◽  
Alkylation Reactions ◽  
Saturated Heterocycles

Asymmetric Rhodium-Catalyzed Allylic Substitution Reactions with Nitrile-Stabilized Carbanions

Synlett ◽  
2021 ◽  
Author(s):  
Mai-Jan Tom ◽  
P. Andrew Evans
Keyword(s):  
Biologically Active ◽  
Allylic Alkylation ◽  
Substitution Reactions ◽  
Stereogenic Centers ◽  
Enantioselective Reactions ◽  
Catalyzed Reactions ◽  
Metal Catalyzed ◽  
Alkylation Reactions ◽  
Quaternary Stereogenic Centers ◽  
Selective Access

This Account summarizes our recent work on rhodium-catalyzed allylic alkylation reactions with nitrile-stabilized carbanions. Despite the challenges associated with employing nitrile stabilized nucleophiles in transition-metal-catalyzed reactions, we recently developed both enantiospecific and enantioselective allylic alkylation reactions. Notably, these novel reactions permit the expedient and selective access to an array of acyclic ternary and quaternary stereogenic centers that are present in important biologically active molecules. 1 Introduction 2 Enantiospecific Reactions of Nitrile-Stabilized Anions 3 Enantioselective Reactions of Nitrile-Stabilized Anions 4 Conclusion

Novel Chiral Ligands for Palladium-catalyzed Asymmetric Allylic Alkylation/ Asymmetric Tsuji-Trost Reaction: A Review

2019 ◽  
Vol 23 (11) ◽  
pp. 1168-1213 ◽  
Author(s):  
Samar Noreen ◽  
Ameer Fawad Zahoor ◽  
Sajjad Ahmad ◽  
Irum Shahzadi ◽  
Ali Irfan ◽  
...  
Keyword(s):  
Asymmetric Catalysis ◽  
Enantioselective Synthesis ◽  
Chiral Ligands ◽  
Allylic Alkylation ◽  
Research Groups ◽  
Asymmetric Allylic Alkylation ◽  
Catalytic Potential ◽  
Long Time ◽  
Palladium Catalyzed ◽  
Alkylation Reactions

Background: Asymmetric catalysis holds a prestigious role in organic syntheses since a long time and chiral inductors such as ligands have been used to achieve the utmost desired results at this pitch. The asymmetric version of Tsuji-Trost allylation has played a crucial role in enantioselective synthesis. Various chiral ligands have been known for Pdcatalyzed Asymmetric Allylic Alkylation (AAA) reactions and exhibited excellent catalytic potential. The use of chiral ligands as asymmetric inductors has widened the scope of Tsuji-Trost allylic alkylation reactions. Conclusion: Therefore, in this review article, a variety of chiral inductors or ligands have been focused for palladium catalyzed asymmetric allylic alkylation (Tsuji-Trost allylation) and in this regard, recently reported literature (2013-2017) has been described. The use of ligands causes the induction of enantiodiscrimination to the allylated products, therefore, the syntheses of various kinds of ligands have been targeted by many research groups to employ in Pd-catalyzed AAA reactions.

scholarly journals Pd-Catalyzed Cross-Electrophile Coupling/C–H Alkylation Reaction Enabled by a Mediator Generated via C(sp3)–H Activation

2021 ◽  
Author(s):  
Zhuo Wu ◽  
Hang Jiang ◽  
Yanghui Zhang
Keyword(s):  
Transition Metal ◽  
Alkyl Group ◽  
Alkylation Reaction ◽  
Aromatic Rings ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Alkylation Reactions

Transition-metal-catalyzed cross-electrophile C(sp2)–(sp3) coupling and C–H alkylation reactions represent two efficient methods for the incorpration of an alkyl group into aromatic rings. Herein, we report a Pd-catalyzed cascade cross-electrophile coupling...

scholarly journals Iridium-Catalyzed Stereoselective Allylic Alkylation Reactions with Crotyl Chloride

2016 ◽  
Vol 55 (52) ◽  
pp. 16092-16095 ◽  
Author(s):  
J. Caleb Hethcox ◽  
Samantha E. Shockley ◽  
Brian M. Stoltz
Keyword(s):  
Allylic Alkylation ◽  
Alkylation Reactions

ChemInform Abstract: Chiral Recognition for Control of Alkene Geometry in a Transition Metal Catalyzed Allylic Alkylation.

ChemInform ◽  
2010 ◽  
Vol 31 (3) ◽  
pp. no-no
Author(s):  
Barry M. Trost ◽  
Christoph Heinemann ◽  
Xavier Ariza ◽  
Stefan Weigand
Keyword(s):  
Transition Metal ◽  
Chiral Recognition ◽  
Allylic Alkylation ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed
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