ChemInform Abstract: Iron-Catalyzed Tandem Cyclization of Olefinic Dicarbonyl Compounds with Benzylic Csp3-H Bonds for the Synthesis of Dihydrofurans.

ChemInform ◽  
2015 ◽  
Vol 46 (29) ◽  
pp. no-no
Author(s):  
Li-Na Guo ◽  
Shun Wang ◽  
Xin-Hua Duan ◽  
Shi-Liu Zhou
Keyword(s):  
Dicarbonyl Compounds ◽  
Tandem Cyclization

Iron-catalyzed tandem cyclization of olefinic dicarbonyl compounds with benzylic Csp3–H bonds for the synthesis of dihydrofurans

2015 ◽  
Vol 51 (23) ◽  
pp. 4803-4806 ◽  
Author(s):  
Li-Na Guo ◽  
Shun Wang ◽  
Xin-Hua Duan ◽  
Shi-Liu Zhou
Keyword(s):  
Radical Cyclization ◽  
Quaternary Carbon ◽  
Dicarbonyl Compounds ◽  
Ready Access ◽  
Tandem Cyclization

A novel iron-catalyzed radical cyclization of olefinic dicarbonyl compounds with benzyl hydrocarbons and simple alkanes has been developed. This protocol provides ready access to a variety of dihydrofurans containing a quaternary carbon center in moderate to good yields.

Facile Synthesis of Polysubstituted Imidazoles through CBr4-Mediated Tandem Cyclization of Amidines with 1,3-Dicarbonyl Compounds or Ketones

2016 ◽  
Vol 2017 (2) ◽  
pp. 237-240 ◽  
Author(s):  
Xiaoqiang Zhou ◽  
Haojie Ma ◽  
Chong Shi ◽  
Yixin Zhang ◽  
XingXing Liu ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Dicarbonyl Compounds ◽  
Tandem Cyclization

Dicarbonyl derived post-translational modifications: chemistry bridging biology and aging-related disease

2020 ◽  
Vol 64 (1) ◽  
pp. 97-110
Author(s):  
Christian Sibbersen ◽  
Mogens Johannsen
Keyword(s):  
Mass Spectrometry ◽  
Future Research ◽  
Amino Acid Residues ◽  
Post Translational Modification ◽  
Dicarbonyl Compounds ◽  
Protein Targets ◽  
Post Translational Modifications ◽  
Reactive Protein ◽  
Glycation End Products ◽  
Direct Mass Spectrometry

Abstract In living systems, nucleophilic amino acid residues are prone to non-enzymatic post-translational modification by electrophiles. α-Dicarbonyl compounds are a special type of electrophiles that can react irreversibly with lysine, arginine, and cysteine residues via complex mechanisms to form post-translational modifications known as advanced glycation end-products (AGEs). Glyoxal, methylglyoxal, and 3-deoxyglucosone are the major endogenous dicarbonyls, with methylglyoxal being the most well-studied. There are several routes that lead to the formation of dicarbonyl compounds, most originating from glucose and glucose metabolism, such as the non-enzymatic decomposition of glycolytic intermediates and fructosyl amines. Although dicarbonyls are removed continuously mainly via the glyoxalase system, several conditions lead to an increase in dicarbonyl concentration and thereby AGE formation. AGEs have been implicated in diabetes and aging-related diseases, and for this reason the elucidation of their structure as well as protein targets is of great interest. Though the dicarbonyls and reactive protein side chains are of relatively simple nature, the structures of the adducts as well as their mechanism of formation are not that trivial. Furthermore, detection of sites of modification can be demanding and current best practices rely on either direct mass spectrometry or various methods of enrichment based on antibodies or click chemistry followed by mass spectrometry. Future research into the structure of these adducts and protein targets of dicarbonyl compounds may improve the understanding of how the mechanisms of diabetes and aging-related physiological damage occur.

ChemInform Abstract: CONDENSATION OF O-AMINOPHENOL AND α-DICARBONYL COMPOUNDS. PART 1. BENZOXAZINES

1978 ◽  
Vol 9 (18) ◽  
Author(s):  
E. BELGODERE ◽  
R. BOSSIO ◽  
V. PARRINI ◽  
R. PEPINO
Keyword(s):  
Dicarbonyl Compounds

scholarly journals Stereoselective Tandem Iridium-Catalyzed Alkene Isomerization-Cope Rearrangement of ω-diene Epoxides: Efficient Access to Acyclic 1,6-Dicarbonyl Compounds

2021 ◽  
Author(s):  
Rahul Suresh ◽  
Itai Massad ◽  
Ilan Marek
Keyword(s):  
Bond Cleavage ◽  
Cope Rearrangement ◽  
Dicarbonyl Compounds ◽  
Alkene Isomerization ◽  
Efficient Access

The Cope rearrangement of 2,3-divinyloxiranes, a rare example of epoxide C-C bond cleavage, results in 4,5-dihydrooxepines which are amenable to hydrolysis, furnishing 1,6-dicarbonyl compounds containing two contiguous stereocenters at the 3- and 4- positions. We employ...

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