ChemInform Abstract: Backbone Amide Linker Strategy: Protocols for the Synthesis of C-Terminal Peptide Aldehydes

ChemInform ◽  
2015 ◽  
Vol 46 (20) ◽  
pp. no-no
Author(s):  
Pernille Tofteng Shelton ◽  
Knud J. Jensen
Keyword(s):  
Backbone Amide ◽  
Peptide Aldehydes ◽  
Backbone Amide Linker

Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle

2000 ◽  
Vol 41 (32) ◽  
pp. 6131-6135 ◽  
Author(s):  
Fanny Guillaumie ◽  
Joseph C Kappel ◽  
Nicholas M Kelly ◽  
George Barany ◽  
Knud J Jensen
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Backbone Amide ◽  
Peptide Aldehydes ◽  
Backbone Amide Linker

Solid-phase synthesis of peptide aldehydes by a Backbone Amide Linker (BAL) strategy

2006 ◽  
pp. 100-101
Author(s):  
Fanny Guillaumie ◽  
Nicholas M. Kelly ◽  
Joseph C. Kappel ◽  
George Barany ◽  
Knud J. Jensen
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Backbone Amide ◽  
Peptide Aldehydes ◽  
Backbone Amide Linker

Backbone Amide Linker Strategies for the Solid-Phase Synthesis of C-Terminal Modified Peptides

ChemInform ◽  
2006 ◽  
Vol 37 (9) ◽  
Author(s):  
Jordi Alsina ◽  
Steven A. Kates ◽  
George Barany ◽  
Fernando Albericio
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Backbone Amide ◽  
Modified Peptides ◽  
Backbone Amide Linker

scholarly journals Fluorescence-Based On-Resin Detection of Three Model Proteases

Chemosensors ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 359
Author(s):  
David Milićević ◽  
Jan Hlaváč
Keyword(s):  
Fluorescent Dyes ◽  
Simultaneous Detection ◽  
Solid Support ◽  
Buffer Solution ◽  
Solution Ph ◽  
New Approach ◽  
Backbone Amide ◽  
Cleavable Peptide ◽  
Backbone Amide Linker ◽  
Competitive Activities

A new approach to on-resin detection of three model proteases (trypsin, chymotrypsin, and thrombin) has been developed, while at the same time already described methodology for simultaneous detection of two enzymes (trypsin and chymotrypsin) has been additionally generalized. Appropriate immobilized substrates, comprising specifically cleavable peptide sequences capped with fluorescent dyes, have been synthesized on Rink Amide PEGA resin or Amino PEGA resin modified with backbone amide linker (BAL). Resulting solid support-bound probes were then dispersed into Tris-HCl buffer solution (pH = 8.0) and subjected to enzymatic cleavage. Liberated fluorophores have been tracked by fluorescence measuring. The competitive activities of studied proteases towards the thrombin probe have been efficiently limited and controlled by employing a Bowman-Birk inhibitor into a system.

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