ChemInform Abstract: Synthesis of 7-Alkoxy-4-trifluoromethylcoumarins via the von Pechmann Reaction Catalyzed by Molecular Iodine.

ChemInform ◽  
2015 ◽  
Vol 46 (16) ◽  
pp. no-no
Author(s):  
Jami DeGrote ◽  
Stephen Tyndall ◽  
Koon Fai Wong ◽  
Melissa VanAlstine-Parris
Keyword(s):  
Molecular Iodine ◽  
Pechmann Reaction

Expeditious Approach to Coumarins via Pechmann Reaction Catalyzed by Molecular Iodine or AgOTf.

ChemInform ◽  
2007 ◽  
Vol 38 (11) ◽  
Author(s):  
Jie Wu ◽  
Tianning Diao ◽  
Wei Sun ◽  
Yizhe Li
Keyword(s):  
Molecular Iodine ◽  
Pechmann Reaction

Synthesis of 7-alkoxy-4-trifluoromethylcoumarins via the von Pechmann reaction catalyzed by molecular iodine

2014 ◽  
Vol 55 (49) ◽  
pp. 6715-6717 ◽  
Author(s):  
Jami DeGrote ◽  
Stephen Tyndall ◽  
Koon Fai Wong ◽  
Melissa VanAlstine-Parris
Keyword(s):  
Molecular Iodine ◽  
Pechmann Reaction

Expeditious Approach to Coumarins via Pechmann Reaction Catalyzed by Molecular Iodine or AgOTf

2006 ◽  
Vol 36 (20) ◽  
pp. 2949-2956 ◽  
Author(s):  
Jie Wu ◽  
Tianning Diao ◽  
Wei Sun ◽  
Yizhe Li
Keyword(s):  
Molecular Iodine ◽  
Pechmann Reaction

Molecular iodine synergized and sensitized neuroblastoma cells to the antineoplastic effect of ATRA

2020 ◽  
Vol 27 (12) ◽  
pp. 699-710
Author(s):  
Irasema Mendieta ◽  
Gabriel Rodríguez-Gómez ◽  
Bertha Rueda-Zarazúa ◽  
Julia Rodríguez-Castelán ◽  
Winniberg Álvarez-León ◽  
...  
Keyword(s):  
Residual Disease ◽  
Neuroblastoma Cells ◽  
Survivin Expression ◽  
Body Weight Loss ◽  
Immunohistochemical Analysis ◽  
Molecular Iodine ◽  
Tyrosine Kinase Receptor ◽  
Adjuvant Effect

Neuroblastoma (NB) is the most common solid childhood tumor, and all-trans retinoic acid (ATRA) is used as a treatment to decrease minimal residual disease. Molecular iodine (I2) induces differentiation and/or apoptosis in several neoplastic cells through activation of PPARγ nuclear receptors. Here, we analyzed whether the coadministration of I2 and ATRA increases the efficacy of NB treatment. ATRA-sensitive (SH-SY5Y), partially-sensitive (SK-N-BE(2)), and non-sensitive (SK-N-AS) NB cells were used to analyze the effect of I2 and ATRA in vitro and in xenografts (Foxn1 nu/nu mice), exploring actions on cellular viability, differentiation, and molecular responses. In the SH-SY5Y cells, 200 μM I2 caused a 100-fold (0.01 µM) reduction in the antiproliferative dose of ATRA and promoted neurite extension and neural marker expression (tyrosine hydroxylase (TH) and tyrosine kinase receptor alpha (Trk-A)). In SK-N-AS, the I2 supplement sensitized these cells to 0.1 μM ATRA, increasing the ATRA-receptor (RARα) and PPARγ expression, and decreasing the Survivin expression. The I2 supplement increased the mitochondrial membrane potential in SK-N-AS suggesting the participation of mitochondrial-mediated mechanisms involved in the sensibilization to ATRA. In vivo, oral I2 supplementation (0.025%) synergized the antitumor effect of ATRA (1.5 mg/kg BW) and prevented side effects (body weight loss and diarrhea episodes). The immunohistochemical analysis showed that I2 supplementation decreased the intratumoral vasculature (CD34). We suggest that the I2 + ATRA combination should be studied in preclinical and clinical trials to evaluate its potential adjuvant effect in addition to conventional treatments.

Organic Domino Reactions Catalyzed by Molecular Iodine

2012 ◽  
Vol 1 (2) ◽  
pp. 137-158 ◽  
Author(s):  
Gunasekar Ramachandran ◽  
Kulathu Sathiyanarayanan
Keyword(s):  
Molecular Iodine ◽  
Domino Reactions

Antiproliferative Effects of Molecular Iodine in Cancers

2011 ◽  
Vol 5 (3) ◽  
pp. 168-176
Author(s):  
Pompilio Elio Torremante ◽  
Harald Rosner
Keyword(s):  
Molecular Iodine ◽  
Antiproliferative Effects
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