ChemInform Abstract: Electrosprayed Nanoparticles and Electrospun Nanofibers Based on Natural Materials: Applications in Tissue Regeneration, Drug Delivery and Pharmaceuticals

ChemInform ◽  
2015 ◽  
Vol 46 (15) ◽  
pp. no-no
Author(s):  
Radhakrishnan Sridhar ◽  
Rajamani Lakshminarayanan ◽  
Kalaipriya Madhaiyan ◽  
Veluchamy Amutha Barathi ◽  
Keith Hsiu Chin Lim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Regeneration ◽  
Electrospun Nanofibers ◽  
Natural Materials

Electrosprayed nanoparticles and electrospun nanofibers based on natural materials: applications in tissue regeneration, drug delivery and pharmaceuticals

2015 ◽  
Vol 44 (3) ◽  
pp. 790-814 ◽  
Author(s):  
Radhakrishnan Sridhar ◽  
Rajamani Lakshminarayanan ◽  
Kalaipriya Madhaiyan ◽  
Veluchamy Amutha Barathi ◽  
Keith Hsiu Chin Lim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Electrospun Nanofibers ◽  
Natural Polymers ◽  
Engineering Applications ◽  
Natural Materials

The role of electrospun and electrosprayed natural polymers or drug ingredients for pharmaceutical and tissue engineering applications is presented in this review.

scholarly journals Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mary Beth Wandel ◽  
Craig A. Bell ◽  
Jiayi Yu ◽  
Maria C. Arno ◽  
Nathan Z. Dreger ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Biological Tissues ◽  
Soft Tissue Regeneration ◽  
Soft Tissue Engineering ◽  
Degradation Properties ◽  
Enhance Cell Adhesion

AbstractComplex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.

scholarly journals Fast Dissolving Electrospun Nanofibers Fabricated from Jelly Fig Polysaccharide/Pullulan for Drug Delivery Applications

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 241
Author(s):  
Thangavel Ponrasu ◽  
Bei-Hsin Chen ◽  
Tzung-Han Chou ◽  
Jia-Jiuan Wu ◽  
Yu-Shen Cheng
Keyword(s):  
Drug Delivery ◽  
Water Vapor Permeability ◽  
Electrospun Nanofibers ◽  
Average Diameter ◽  
Xrd Analysis ◽  
Water Soluble ◽  
Vapor Permeability ◽  
Uv Spectrum ◽  
Sem Images ◽  
Triton X

The fast-dissolving drug delivery systems (FDDDSs) are developed as nanofibers using food-grade water-soluble hydrophilic biopolymers that can disintegrate fast in the oral cavity and deliver drugs. Jelly fig polysaccharide (JFP) and pullulan were blended to prepare fast-dissolving nanofiber by electrospinning. The continuous and uniform nanofibers were produced from the solution of 1% (w/w) JFP, 12% (w/w) pullulan, and 1 wt% Triton X-305. The SEM images confirmed that the prepared nanofibers exhibited uniform morphology with an average diameter of 144 ± 19 nm. The inclusion of JFP in pullulan was confirmed by TGA and FTIR studies. XRD analysis revealed that the increased crystallinity of JFP/pullulan nanofiber was observed due to the formation of intermolecular hydrogen bonds. The tensile strength and water vapor permeability of the JFP/pullulan nanofiber membrane were also enhanced considerably compared to pullulan nanofiber. The JFP/pullulan nanofibers loaded with hydrophobic model drugs like ampicillin and dexamethasone were rapidly dissolved in water within 60 s and release the encapsulants dispersive into the surrounding. The antibacterial activity, fast disintegration properties of the JFP/pullulan nanofiber were also confirmed by the zone of inhibition and UV spectrum studies. Hence, JFP/pullulan nanofibers could be a promising carrier to encapsulate hydrophobic drugs for fast-dissolving/disintegrating delivery applications.

Electrospun nanofibers comprising of silk fibroin/gelatin for drug delivery applications: Thyme essential oil and doxycycline monohydrate release study

2018 ◽  
Vol 106 (4) ◽  
pp. 1092-1103 ◽  
Author(s):  
Masoud Dadras Chomachayi ◽  
Atefeh Solouk ◽  
Somaye Akbari ◽  
Davoud Sadeghi ◽  
Fereshteh Mirahmadi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Essential Oil ◽  
Silk Fibroin ◽  
Electrospun Nanofibers ◽  
Thyme Essential Oil ◽  
Release Study ◽  
Drug Delivery Applications

scholarly journals Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery

2012 ◽  
Vol 370 (1963) ◽  
pp. 1400-1421 ◽  
Author(s):  
María Vallet-Regí ◽  
Isabel Izquierdo-Barba ◽  
Montserrat Colilla
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Cells ◽  
Added Value ◽  
Bone Tissue Regeneration ◽  
Local Drug Delivery ◽  
Chemical Compositions ◽  
Sustained Drug Release

This review article describes the importance of structure and functionalization in the performance of mesoporous silica bioceramics for bone tissue regeneration and local drug delivery purposes. Herein, we summarize the pivotal features of mesoporous bioactive glasses, also known as ‘templated glasses’ (TGs), which present chemical compositions similar to those of conventional bioactive sol–gel glasses and the added value of an ordered mesopore arrangement. An in-depth study concerning the possibility of tailoring the structural and textural characteristics of TGs at the nanometric scale and their influence on bioactive behaviour is discussed. The highly ordered mesoporous arrangement of cavities allows these materials to confine drugs to be subsequently released, acting as drug delivery devices. The functionalization of mesoporous silica walls has been revealed as the cornerstone in the performance of these materials as controlled release systems. The synergy between the improved bioactive behaviour and local sustained drug release capability of mesostructured materials makes them suitable to manufacture three-dimensional macroporous scaffolds for bone tissue engineering. Finally, this review tackles the possibility of covalently grafting different osteoinductive agents to the scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

scholarly journals A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Matrices

2018 ◽  
Vol 15 (10) ◽  
pp. 1360-1374 ◽  
Author(s):  
Erick José Torres-Martinez ◽  
José Manuel Cornejo Bravo ◽  
Aracely Serrano Medina ◽  
Graciela Lizeth Pérez González ◽  
Luis Jesús Villarreal Gómez
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Electrospun Nanofibers
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