ChemInform Abstract: Efficient Synthesis of Conformationally Constrained, Amino-triazoloazepinone-containing Di- and Tripeptides via a One-Pot Ugi-Huisgen Tandem Reaction.

ChemInform ◽  
2015 ◽  
Vol 46 (8) ◽  
pp. no-no
Author(s):  
T. M. A. Barlow ◽  
M. Jida ◽  
D. Tourwe ◽  
S. Ballet
Keyword(s):  
Tandem Reaction ◽  
Efficient Synthesis ◽  
One Pot ◽  
Conformationally Constrained

Efficient synthesis of conformationally constrained, amino-triazoloazepinone-containing di- and tripeptides via a one-pot Ugi–Huisgen tandem reaction

2014 ◽  
Vol 12 (36) ◽  
pp. 6986-6989 ◽  
Author(s):  
T. M. A. Barlow ◽  
M. Jida ◽  
D. Tourwé ◽  
S. Ballet
Keyword(s):  
Tandem Reaction ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
One Pot ◽  
Conformationally Constrained ◽  
Catalyst Free

Herein we describe a catalyst-free procedure employing an Ugi-4CR followed by a thermal azide–alkyne Huisgen cycloaddition to generate a 16-member library with up to four points of diversification and high atom economy.

One-pot atom-efficient synthesis of bio-renewable polyesters and cyclic carbonates through tandem catalysis

2015 ◽  
Vol 51 (40) ◽  
pp. 8504-8507 ◽  
Author(s):  
Fan Jia ◽  
Xiaoyu Chen ◽  
Yan Zheng ◽  
Yusheng Qin ◽  
Youhua Tao ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Cyclic Carbonates ◽  
Tandem Catalysis ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Salen Complexes ◽  
High Yields ◽  
First Time

One-pot synthesis of well-defined bio-renewable polyesters and cyclic carbonates in high yields was successfully realized for the first time by way of a tandem reaction using metal salen complexes as catalysts.

scholarly journals Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

2013 ◽  
Vol 9 ◽  
pp. 2846-2851 ◽  
Author(s):  
Haijun Qu ◽  
Xuejian Li ◽  
Fan Mo ◽  
Xufeng Lin
Keyword(s):  
Molecular Iodine ◽  
Tandem Reaction ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Type Reaction ◽  
Reaction Proceeds ◽  
Phosphoric Acids ◽  
Substituted Urea

A one-pot three-component synthesis of dihydropyrimidinones via a molecular iodine-catalyzed tandem reaction of simple readily available mono-substituted urea, alkylaldehyde, and arylaldehyde has been developed. The reaction proceeds with high chemo- and regioselectivity to give highly diverse dihydropyrimidinones in reasonable yields under mild reaction conditions. Moreover, the first catalytic enantioselective version of this reaction was also realized by using chiral spirocyclic SPINOL-phosphoric acids.

A copper-mediated tandem reaction through isocyanide insertion into N–H bonds: efficient access to unsymmetrical tetrasubstituted ureas

2014 ◽  
Vol 50 (12) ◽  
pp. 1465-1468 ◽  
Author(s):  
Xiaomei Huang ◽  
Shuguang Xu ◽  
Qitao Tan ◽  
Mingchun Gao ◽  
Minjie Li ◽  
...  
Keyword(s):  
Tandem Reaction ◽  
Efficient Synthesis ◽  
One Pot ◽  
Efficient Access

A copper-mediated multi-component reaction was developed through isocyanide insertion into N–H bonds of less active secondary arylamines. This approach leads to an efficient synthesis of unsymmetrical tetrasubstituted ureas in one pot.

One-pot cascade reactions of 1-arylpenta-3,4-dien-2-ones leading to 2-arylphenols and dibenzopyroanones

2014 ◽  
Vol 50 (95) ◽  
pp. 14968-14970 ◽  
Author(s):  
Yan He ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Cascade Reactions ◽  
Tandem Reaction ◽  
Efficient Synthesis ◽  
One Pot

A one-pot tandem reaction of 1-arylpenta-3,4-dien-2-ones with activated ketones allowed for an efficient synthesis of 2-arylphenols. Moreover, this reaction was found to be also compatible and combinable with Pd-catalyzed C–H activation and carbonylation of the in situ formed 2-arylphenols to provide dibenzopyranones.

scholarly journals Efficient synthesis of diarylidene octahydroacridines by one-pot multi-component tandem reactions

2008 ◽  
Vol 6 (3) ◽  
pp. 404-409 ◽  
Author(s):  
Qi-Fang Wang ◽  
Chao-Guo Yan
Keyword(s):  
Microwave Irradiation ◽  
Aromatic Aldehydes ◽  
Tandem Reaction ◽  
Tandem Reactions ◽  
Efficient Synthesis ◽  
One Pot ◽  
Molar Equivalent ◽  
High Yields

AbstractA one-pot multi-component reaction is developed for the efficient synthesis of 4,5-dibenzylidene octahydroacridines in high yields. The reaction is performed by the tandem reaction of three molar equivalent aromatic aldehydes with two molar equivalent 4-alkylcyclohexanone in the system of NH4OAc/HOAc under microwave irradiation.

Tandem reaction of Morita–Baylis–Hillman alcohols derived from acrylic nitrile with 2-aminobenzimidazole in ionic liquid [BMIM]Cl/H2O

2012 ◽  
Vol 90 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Yan Wang ◽  
Li Liu ◽  
Dong Wang ◽  
Yong-Jun Chen
Keyword(s):  
Ionic Liquid ◽  
Michael Addition ◽  
Cyano Group ◽  
Reaction Medium ◽  
Tandem Reaction ◽  
Amino Group ◽  
Efficient Synthesis ◽  
One Pot ◽  
Imine Compounds

The tandem reaction of Morita–Baylis–Hillman (MBH) alcohols 1a–1l derived from acrylic nitrile with 2-aminobenzimidazole (2) in ionic iquid (IL) [BMIM]Cl/H2O without additional catalyst was developed for the efficient synthesis of benzimidazol[1,2-a]pyrimidin-7(8H)-imine compounds. The tandem reaction included aza-Michael addition and intramolecular addition of an amino group to the cyano group in one pot. The combination of ionic liquid and water was found to be the best reaction medium, which played a role for accelerating the tandem reaction.

Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

2013 ◽  
Vol 16 (10) ◽  
pp. 788-790
Author(s):  
Zinatossadat Hossaini ◽  
Samereh Seyfi ◽  
Faramarz Rostami-Charati ◽  
Mehdi Ghambarian
Keyword(s):  
Multicomponent Reactions ◽  
Efficient Synthesis ◽  
One Pot ◽  
Imidazole Derivatives ◽  
New Class
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