ChemInform Abstract: Highly Enantioselective Michael Addition of Malonates to β-CF3-β-(3-Indolyl)nitroalkenes: Construction of Trifluoromethylated All-Carbon Quaternary Stereogenic Centers.

ChemInform ◽  
2015 ◽  
Vol 46 (8) ◽  
pp. no-no
Author(s):  
Chun-Hui Ma ◽  
Tai-Ran Kang ◽  
Long He ◽  
Quan-Zhong Liu
Keyword(s):  
Michael Addition ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

scholarly journals A convenient approach to difluoromethylated all-carbon quaternary centers via Ni(ii)-catalyzed enantioselective Michael addition

RSC Advances ◽  
2018 ◽  
Vol 8 (35) ◽  
pp. 19402-19408
Author(s):  
Xuan Yu ◽  
Hui Bai ◽  
Dong Wang ◽  
Zhaohai Qin ◽  
Jia-Qi Li ◽  
...  
Keyword(s):  
Michael Addition ◽  
Quaternary Centers ◽  
Stereogenic Centers ◽  
Convenient Approach ◽  
Quaternary Stereogenic Centers

Ni(ii)-catalyzed enantioselective Michael addition afforded compounds with all-carbon quaternary stereogenic centers featuring a CF2H group in good enantioselectivities.

All-Carbon Quaternary Stereogenic Centers in Acyclic Systems through the Creation of Several C–C Bonds per Chemical Step

2014 ◽  
Vol 136 (7) ◽  
pp. 2682-2694 ◽  
Author(s):  
Ilan Marek ◽  
Yury Minko ◽  
Morgane Pasco ◽  
Tom Mejuch ◽  
Noga Gilboa ◽  
...  
Keyword(s):  
Stereogenic Centers ◽  
The Creation ◽  
Quaternary Stereogenic Centers

Chirality Transfer from a Chiral Primary Alcohol Equivalent Through Allyl Cyanate-to-Isocyanate Rearrangement: Synthesis of (+)-Geranyllinaloisocyanide

Synthesis ◽  
2019 ◽  
Vol 51 (15) ◽  
pp. 2959-2964 ◽  
Author(s):  
Yoshiyasu Ichikawa ◽  
Hirofumi Morimoto ◽  
Toshiya Masuda
Keyword(s):  
Natural Product ◽  
Primary Alcohol ◽  
Marine Natural Product ◽  
Chirality Transfer ◽  
New Approach ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

A new approach was developed to construct quaternary stereogenic centers bearing nitrogen substituents in an enantioselective manner. The strategy takes advantage of [1,3]-chirality transfer from a chiral primary alcohol equivalent through an allyl cyanate-to-isocyanate rearrangement. This approach was employed in an efficient eight-step synthesis of the marine natural product, (+)-geranyllinaloisocyanide, in 43% overall yield.

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