ChemInform Abstract: Multicomponent Reactions of Amino Alcohols with CH2O and Dithiols in the Synthesis of 1,3,5-Dithiazepanes and Macroheterocycles.

ChemInform ◽  
2014 ◽  
Vol 45 (43) ◽  
pp. no-no
Author(s):  
Guzel R. Khabibullina ◽  
Vnira R. Akhmetova ◽  
Marat F. Abdullin ◽  
Tatiana V. Tyumkina ◽  
Leonard M. Khalilov ◽  
...  
Keyword(s):  
Multicomponent Reactions ◽  
Amino Alcohols

Multicomponent reactions of amino alcohols with CH2O and dithiols in the synthesis of 1,3,5-dithiazepanes and macroheterocycles

Tetrahedron ◽  
2014 ◽  
Vol 70 (21) ◽  
pp. 3502-3509 ◽  
Author(s):  
Guzel R. Khabibullina ◽  
Vnira R. Akhmetova ◽  
Marat F. Abdullin ◽  
Tatiana V. Tyumkina ◽  
Leonard M. Khalilov ◽  
...  
Keyword(s):  
Multicomponent Reactions ◽  
Amino Alcohols

Synthetic Routes to 1,4,5,6-Tetrahydropyrimidines: An Overview and Recent Advances

2019 ◽  
Vol 23 (17) ◽  
pp. 1843-1856
Author(s):  
Aditya Bhattacharyya
Keyword(s):  
Carbonyl Compounds ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Biological Significance ◽  
Selective Reduction ◽  
Ring Expansion ◽  
Amino Alcohols ◽  
Review Article ◽  
Pharmacological Properties ◽  
Synthetic Routes

Partially reduced heterocyclic compounds such as 1,4,5,6-tetrahydropyrimidines are often found to possess interesting pharmacological properties. Yet, the synthetic routes towards such systems are less developed than their fully aromatic counterparts. In this review article, the biological significance of 1,4,5,6-tetrahydropyrimidines is discussed and the existing literature reports describing various preparative routes to access 1,4,5,6-tetrahydropyrimidine derivatives have been categorically described. The focus has been expanded to present an overview of the chronological development of the traditional synthetic routes as well as the contemporary approaches to 1,4,5,6-tetrahydropyrimidines that generally include: (i) condensation reactions of diamines with various appropriate counterparts such as carbonyl compounds, imino ethers, amidines or nitriles, condensation of amidines with 1,3-dibromopropane and α,β-unstaurated carbonyl compounds, condensation of amino alcohols; (ii) selective reduction of pyrimidines; (iii) ring expansion chemistry of cyclopropanes, aziridines, and azetidines; and (iv) miscellaneous examples such as various multicomponent reactions.

Sign in / Sign up

Export Citation Format

Share Document