ChemInform Abstract: Synthesis and Antifungal Activity of Some New Derivatives of 5-{4′-(2′′,4′′-Dichlorobenzyloxy)-phenyl}-1,3,4-oxadiazole-2 (3H)-thione.

ChemInform ◽  
2013 ◽  
Vol 44 (50) ◽  
pp. no-no ◽  
Author(s):  
Nisheeth Rastogi ◽  
Darwin Anil Harrison
Keyword(s):  
Antifungal Activity ◽  
Derivatives Of

Synthesis of Carbamic Esters Derivatives of Itols:  Antifungal Activity against Various Crop Diseases

1997 ◽  
Vol 45 (1) ◽  
pp. 3-6 ◽  
Author(s):  
Christophe Len ◽  
Denis Postel ◽  
Gino Ronco ◽  
Pierre Villa ◽  
Christel Goubert ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Crop Diseases ◽  
Carbamic Esters ◽  
Derivatives Of

Synthesis and Antifungal Activity of N-Benzyl Derivatives of Tetramycin B

2021 ◽  
Vol 91 (6) ◽  
pp. 1028-1038
Author(s):  
V. V. Belakhov ◽  
T. B. Chistyakova ◽  
E. E. Musayev ◽  
I. A. Smirnov ◽  
V. A. Kolodyaznaya
Keyword(s):  
Antifungal Activity ◽  
Derivatives Of

scholarly journals Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A1 (S44HP)

2009 ◽  
Vol 63 (2) ◽  
pp. 55-64 ◽  
Author(s):  
Maria N Preobrazhenskaya ◽  
Eugenia N Olsufyeva ◽  
Anna N Tevyashova ◽  
Svetlana S Printsevskaya ◽  
Svetlana E Solovieva ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Genetically Engineered ◽  
Polyene Antibiotic ◽  
Derivatives Of

2-Hydroxypropyl derivatives of 1,2,3-thiadiazole and 1,2,3-triazole: Synthesis and antifungal activity

2011 ◽  
Vol 83 (3) ◽  
pp. 715-722 ◽  
Author(s):  
Yury Morzherin ◽  
Polina E. Prokhorova ◽  
Dmitry A. Musikhin ◽  
Tatiana V. Glukhareva ◽  
Zhijin Fan
Keyword(s):  
Mass Spectrometry ◽  
Antifungal Activity ◽  
Ir Spectroscopy ◽  
Elemental Analysis ◽  
Antifungal Activities ◽  
Triazole Derivatives ◽  
New Compounds ◽  
Derivatives Of

A series of novel 5-(2-hydroxypropyl)amino-1,2,3-thiadiazole and 5-(2-hydroxy-propyl)sulfanyl-1,2,3-triazole derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by NMR and IR spectroscopy, mass spectrometry, and elemental analysis. Their antifungal activities were evaluated.

scholarly journals Synthesis and antimicrobial screening of pyrano[3,2-c]chromene derivatives of 1H-pyrazoles

2011 ◽  
Vol 9 (4) ◽  
pp. 635-647 ◽  
Author(s):  
Chetan Sangani ◽  
Divyesh Mungra ◽  
Manish Patel ◽  
Ranjan Patel
Keyword(s):  
Antifungal Activity ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Fungal Pathogens ◽  
Broth Microdilution ◽  
One Pot ◽  
E Coli ◽  
Cyclocondensation Reaction ◽  
Ft Ir ◽  
Derivatives Of

AbstractA new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial drugs against most of employed strains, as evident from the screening data.

ChemInform Abstract: Derivatives of a Novel Cyclopeptolide. Part 1. Synthesis, Antifungal Activity, and Structure-Activity Relationships.

ChemInform ◽  
2010 ◽  
Vol 25 (50) ◽  
pp. no-no
Author(s):  
G. EMMER ◽  
M. A. GRASSBERGER ◽  
J. G. MEINGASSNER ◽  
G. SCHULZ ◽  
M. SCHAUDE
Keyword(s):  
Antifungal Activity ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Derivatives Of

scholarly journals Antimicrobial and antifungal activity of new fluorophenyl-containing 1,2,4-triazoles

2021 ◽  
pp. 87-93
Author(s):  
О. А. Бігдан
Keyword(s):  
Staphylococcus Aureus ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Practical Significance ◽  
Scientific Publications ◽  
Reference Drug ◽  
Minimum Concentration ◽  
Antimicrobial And Antifungal Activity ◽  
Derivatives Of ◽  
Serial Dilutions

The achievements of the world organic chemistry are most clearly represented by scientific publications that prove the promising nature of heterocyclic substances. The possibility of combining various pharmacophore fragments and 1,2,4-triazole in one molecule is quite popular. In 2018, the drug Trifuzol-NEO appeared on the veterinary market of Ukraine, which took its rightful place among synthetic immunomodulators for various groups of unproductive animals. So, further studies of new promising compounds among substituted 1,2,4-triazole, which can be used as objects for the creation of new original domestic antimicrobial and antifungal agents, remains relevant and has theoretical and practical significance. The aim of our work was to investigate the antimicrobial and antifungal activity of a number of new fluorophenyl-containing derivatives of 1,2,4-triazole and, in some cases, to trace the presence of certain patterns between structure and action. The sensitivity of new fluorophenyl-containing derivatives of 1,2.4-triazole was studied by the method of serial dilutions in accordance with the methodological recommendations. From the initial concentration of the new synthesized compounds of 1 mg/ml, a series of two-fold serial dilutions were prepared in Mueller–Hinton broth in a volume of 1 ml. Then, 0.1 ml of microbial curtain (106 m. c./ml) was added to each tube. MIC (MIC) was determined in the absence of visible growth in a test tube with the minimum concentration of the drug, the minimum bactericidal concentration (MBcK) – in the absence of growth on agar after inoculation from transparent tubes. Dimethyl sulfoxide was used as a solvent for the compounds in the studies. The research was carried out at the Department of Microbiology, Virology and Immunology of Zaporizhzhia State Medical University. Analyzing the results of studying the sensitivity of substances to Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, it should be noted that almost all compounds were active against the bacteria. It should be noted that a number of compounds were found to be the most active against Staphylococcus aureus, and 5-(2-fluorophenyl)-4-(((5-nitrofuran-2-yl)methylene)amino-4H-1,2,4-triazole-3-thiols generally exceeded several times the activity indices of the reference drug (MIC 1.95 μg/ml, MBcK 3.9 μg/ml) to Staphylococcus aureus. Most of the compounds were found to be quite active against Candida albicans. Among the corresponding 5-(2-fluorophenyl)-4-((aryl)ylidene)amino-1,2,4-triazole-3-thiols, the highest activity for Candida albicans exhibit 5-(2-fluorophenyl) -4-((4-bromophenyl)ylidene)amino-1,2,4-triazole-3-thiol and 5-(2-fluorophenyl)-4-((2,3-dimethoxyphenyl)ylidene)amino-1,2,4-triazole-3-thiol. It was found that most of the compounds exhibit a moderate antimicrobial and a fairly high antifungal effect. The most sensitive strain was S. aureus in relation to 5-(2-fluorophenyl)-4-(((5-nitrofurans-2-yl)methylene)amino-4H-1,2,4-triazole-3-thiol, Candida albicans proved to be very sensitive to 5-(2-fluorophenyl)-4-((4-bromophenyl)ylidene)amino-1,2,4-triazole-3-thiol and 5-(2-fluorophenyl)-4((2,3-dimethoxyphenyl)ylidene)amino-1,2,4-triazole-3-thiol.

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