ChemInform Abstract: A Mild, One-Pot Stadler-Ziegler Synthesis of Arylsulfides Facilitated by Photoredox Catalysis in Batch and Continuous-Flow.

ChemInform ◽  
2013 ◽  
Vol 44 (50) ◽  
pp. no-no
Author(s):  
Xiao Wang ◽  
Gregory D. Cuny ◽  
Timothy Noel
Keyword(s):  
Continuous Flow ◽  
Photoredox Catalysis ◽  
One Pot

One-pot synthesis of tricyclo-1,4-benzoxazines via visible-light photoredox catalysis in continuous flow

2017 ◽  
Vol 58 (14) ◽  
pp. 1395-1398 ◽  
Author(s):  
Guolin Wu ◽  
Tingting Lv ◽  
Wenhui Mo ◽  
Xiping Yang ◽  
Yu Gao ◽  
...  
Keyword(s):  
Visible Light ◽  
Continuous Flow ◽  
Photoredox Catalysis ◽  
One Pot ◽  
One Pot Synthesis

Fast and high-efficiency synthesis of 2-substituted benzothiazoles via combining enzyme catalysis and photoredox catalysis in one-pot

2020 ◽  
pp. 104607
Author(s):  
Zeng-Jie Yang ◽  
Qing-Tian Gong ◽  
Yuan Yu ◽  
Wei-Fan Lu ◽  
Zhe-Ning Wu ◽  
...  
Keyword(s):  
Enzyme Catalysis ◽  
High Efficiency ◽  
Photoredox Catalysis ◽  
One Pot

Batch and Continuous-Flow One-Pot Processes using Amine Diazotization to Produce Silylated Diazo Reagents

2017 ◽  
Vol 56 (22) ◽  
pp. 6294-6297 ◽  
Author(s):  
Clément Audubert ◽  
Oscar Javier Gamboa Marin ◽  
Hélène Lebel
Keyword(s):  
Continuous Flow ◽  
One Pot ◽  
Diazo Reagents

Continuous Flow α-Trifluoromethylation of Ketones by Metal-Free Visible Light Photoredox Catalysis

2014 ◽  
Vol 16 (3) ◽  
pp. 896-899 ◽  
Author(s):  
David Cantillo ◽  
Oscar de Frutos ◽  
Juan A. Rincón ◽  
Carlos Mateos ◽  
C. Oliver Kappe
Keyword(s):  
Visible Light ◽  
Continuous Flow ◽  
Photoredox Catalysis ◽  
Metal Free

scholarly journals High Yielding Flow Synthesis of a Macrocyclic Molecular Hinge

2021 ◽  
Author(s):  
Christopher Jones ◽  
Laurence J. Kershaw Cook ◽  
David Marquez-Gamez ◽  
Konstantin V. Luzyanin ◽  
Jonathan Steed ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Continuous Flow ◽  
Kinetic Studies ◽  
Molecular Machines ◽  
High Dilution ◽  
Fluoride Ions ◽  
One Pot ◽  
Flow Synthesis ◽  
Single Isomer ◽  
Molecular Hinge

ABSTRACT: Many molecular machines are built from modular components with well-defined motile capabilities, such as axles and wheels. Hinges are particularly useful, as they provide the minimum flexibility needed for a simple and pronounced conformational change. Compounds with multiple stable conformers are common, but molecular hinges almost exclusively operate via dihedral rotations rather than truly hinge-like clamping mechanisms. An ideal molecular hinge would better reproduce the behavior of hinged devices, such as gates and tweezers, while remaining soluble, scalable and synthetically versatile. Herein, we describe two isomeric macrocycles with clamp-like open and closed geometries, which crystallize as separate polymorphs but interconvert freely in solution. An unusual one-pot addition cyclization reaction was used to produce the macrocycles on a multigram scale from inexpensive reagents, without supramolecular templating or high-dilution conditions. Using mechanistic information from NMR kinetic studies and at-line mass spectrometry, we developed a semi-continuous flow synthesis with maximum conversions of 85-93% and over 80% selectivity for a single isomer. The macrocycles feature voids that are sterically protected from guests, including reactive species such as fluoride ions, and could therefore serve as chemically inert hinges for adaptive supramolecular receptors and flexible porous materials.

scholarly journals A ABORDAGEM TELESCÓPICA COMO FERRAMENTA DA QUÍMICA VERDE

Química Nova ◽  
2021 ◽  
Author(s):  
Vitor Andrade ◽  
Marcio Mattos
Keyword(s):  
Green Chemistry ◽  
Organic Synthesis ◽  
Continuous Flow ◽  
Cost Savings ◽  
Cross Coupling ◽  
Waste Generation ◽  
One Pot ◽  
Sequential Reactions

THE TELESCOPIC APPROACH AS A TOOL FOR GREEN CHEMISTRY. One-pot reactions have become a powerful tool for the development of sustainable protocols in organic synthesis. In particular, the telescoping of multi-step reactions, i.e., the execution of sequential reactions without isolating and purifying intermediates, reduces the number of steps while preventing waste generation. Additionally, the processes become more sustainable through time, reagents/solvents, energy and cost savings. Therefore, the aim of this work is to summarize and discuss representative one-pot telescoped strategies involving heterocyclic construction, cross-coupling and continuous-flow reactions.

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