ChemInform Abstract: Facile Synthesis of 2-Iodo-spiro[indene-1,1′-isobenzofuran]-3′-ones via Iodine-Promoted Cascade Cyclization.

ChemInform ◽  
2013 ◽  
Vol 44 (8) ◽  
pp. no-no
Author(s):  
Hai-Tao Zhu ◽  
Xue Dong ◽  
Li-Jing Wang ◽  
Mei-Jin Zhong ◽  
Xue-Yuan Liu ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Cascade Cyclization

Facile synthesis of 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′-ones via iodine-promoted cascade cyclization

2012 ◽  
Vol 48 (87) ◽  
pp. 10748 ◽  
Author(s):  
Hai-Tao Zhu ◽  
Xue Dong ◽  
Li-Jing Wang ◽  
Mei-Jin Zhong ◽  
Xue-Yuan Liu ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Cascade Cyclization

Facile synthesis of carbamoylated benzimidazo[2,1-a]isoquinolin-6(5H)-ones via radical cascade cyclization under metal-free conditions

2021 ◽  
Author(s):  
Qi Liu ◽  
Lei Wang ◽  
Jie Liu ◽  
Shuchen Ruan ◽  
Pinhua Li
Keyword(s):  
Efficient Synthesis ◽  
Facile Synthesis ◽  
Metal Free ◽  
Cascade Cyclization ◽  
Highly Efficient ◽  
Radical Cascade

A highly efficient synthesis of carbamoylated benzimidazo[2,1-a]isoquinolin-6(5H)-ones using 2-arylbenzoimidazoles and oxamic acids was developed. This strategy tolerated various substrates on the starting materials to generate the corresponding products in good...

Facile synthesis of 11-aryl-6H-isoindolo[2,1-a]indol-6-ones via hypervalent iodine(iii)-promoted cascade cyclization

RSC Advances ◽  
2015 ◽  
Vol 5 (17) ◽  
pp. 13102-13106 ◽  
Author(s):  
Kapil Dev ◽  
Rakesh Maurya
Keyword(s):  
Efficient Method ◽  
Ring System ◽  
Hypervalent Iodine ◽  
Facile Synthesis ◽  
Metal Free ◽  
Cascade Cyclization

An efficient method was developed for the synthesis of a tetracyclic fused indole and isoindoline ring system, under metal-free conditions.

Biotemplated facile synthesis of three‐dimensional micro/nanoporous tin oxide: improving the flammable and mechanical properties of flexible PVC

2019 ◽  
Vol 14 (8) ◽  
pp. 828-830 ◽  
Author(s):  
Weihua Meng ◽  
Weihong Wu ◽  
Weiwei Zhang ◽  
Luyao Cheng ◽  
Yunhong Jiao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tin Oxide ◽  
Three Dimensional ◽  
Facile Synthesis

Selective Degradation of Grindelic Acid and Its 3α-Hydroxy Analog: Facile Synthesis of Grindelistrictic Acids and Potential Intermediates for Erigerol

Synlett ◽  
1991 ◽  
Vol 1991 (09) ◽  
pp. 725-727 ◽  
Author(s):  
Takeshi Shimizu ◽  
Sayoko Hiranuma ◽  
Zhao-hui Qian ◽  
Hirosuke Yoshioka
Keyword(s):  
Facile Synthesis ◽  
Selective Degradation

A FACILE SYNTHESIS AND REACTIONS OF AMINO SELENOLO[2,3-b]PYRIDINE CARBOXYLATE

2015 ◽  
Vol 12 (1) ◽  
pp. 3910-3918 ◽  
Author(s):  
Dr Remon M Zaki ◽  
Prof Adel M. Kamal El-Dean ◽  
Dr Nermin A Marzouk ◽  
Prof Jehan A Micky ◽  
Mrs Rasha H Ahmed
Keyword(s):  
Biological Activity ◽  
Carbonyl Compounds ◽  
Mass Spectra ◽  
The Other ◽  
Pyridine Derivatives ◽  
Facile Synthesis ◽  
High Biological Activity ◽  
Basic Hydrolysis ◽  
Pyridine Carboxylate ◽  
Hydrolysis Of

 Incorporating selenium metal bonded to the pyridine nucleus was achieved by the reaction of selenium metal with 2-chloropyridine carbonitrile 1 in the presence of sodium borohydride as reducing agent. The resulting non isolated selanyl sodium salt was subjected to react with various α-halogenated carbonyl compounds to afford the selenyl pyridine derivatives 3a-f  which compounds 3a-d underwent Thorpe-Ziegler cyclization to give 1-amino-2-substitutedselenolo[2,3-b]pyridine compounds 4a-d, while the other compounds 3e,f failed to be cyclized. Basic hydrolysis of amino selenolo[2,3-b]pyridine carboxylate 4a followed by decarboxylation furnished the corresponding amino selenolopyridine compound 6 which was used as a versatile precursor for synthesis of other heterocyclic compound 7-16. All the newly synthesized compounds were established by elemental and spectral analysis (IR, 1H NMR) in addition to mass spectra for some of them hoping these compounds afforded high biological activity.

S(IV)–Mediated Unsymmetrical Heterocycle Cross-Couplings

2019 ◽  
Author(s):  
Min Zhou ◽  
Jet Tsien ◽  
Tian Qin
Keyword(s):  
Cross Coupling ◽  
Reductive Elimination ◽  
Facile Synthesis ◽  
Trigonal Bipyramidal

<p>Herein we report a sulfur (IV) mediated cross-coupling for facile synthesis of heteroaromatic substrates. Addition of heteroaryl nucleophiles onto a simple, readily-accessible alkyl sulfinyl (IV) chloride allows formation of a trigonal bipyramidal sulfurane intermediate. Reductive elimination therefrom provides bis-heteroaryl products in a practical and efficient fashion. <br></p>

Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents

2020 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Cassandra R. Youshaw ◽  
Mingbin Yuan ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Turnover Frequency ◽  
Diverse Range ◽  
Cascade Cyclization ◽  
Radical Cascade

The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleophiles, alkyl halides, and unactivated olefins bearing diverse functional groups to yield the desired 1,2-alkylarylated products with high regiocontrol. Further, we demonstrate that this protocol is amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines via a three-component radical cascade cyclization/arylation that forges three new C-C bonds.

Facile Synthesis of a Diverse Library of Mono-3-substituted β-Cyclodextrin Analogues

2018 ◽  
Author(s):  
Kathryn Kellett ◽  
Brendan M. Duggan ◽  
Michael Gilson
Keyword(s):  
High Yield ◽  
Facile Synthesis ◽  
Wide Range

We have described simple, high-yield, protocols, which require only commonly accessible equipment, to synthesize a wide range of β-CD derivatives mono-substituted at the secondary face. These derivatives may be useful in their own right, and they are also scaffolds for further modification, and examples of the far broader array of derivatives that may be accessed by these procedures.

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