ChemInform Abstract: Synthesis and Spectral Characterization of Related Substances of Vardenafil, an Erectile Dysfunction Drug

ChemInform ◽  
2013 ◽  
Vol 44 (5) ◽  
pp. no-no
Author(s):  
Vajrala Venkata Reddy ◽  
Mandava Venkata Naga ◽  
Brahmeswara Rao ◽  
Ghanta Mahesh Reddy ◽  
Khagga Mukkanti ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Spectral Characterization ◽  
Related Substances ◽  
Erectile Dysfunction Drug

Synthesis and Spectral Characterization of Related Substances of Vardenafil, an Erectile Dysfunction Drug

2012 ◽  
Vol 42 (23) ◽  
pp. 3513-3523 ◽  
Author(s):  
Vajrala Venkata Reddy ◽  
Mandava Venkata Naga Brahmeswara Rao ◽  
Ghanta Mahesh Reddy ◽  
Khagga Mukkanti ◽  
Ganta Madhusudhan Reddy
Keyword(s):  
Erectile Dysfunction ◽  
Spectral Characterization ◽  
Related Substances ◽  
Erectile Dysfunction Drug

scholarly journals Identification, Synthesis, Isolation and Spectral Characterization of Multidrug-Resistant Tuberculosis (MDR-TB) Related Substances

2018 ◽  
Vol 08 (02) ◽  
pp. 190-207
Author(s):  
Sureshbabu Jayachandra ◽  
Madhuresh Kumar Sethi ◽  
Vipin Kumar Kaushik ◽  
Vijayakrishna Ravi ◽  
Saiprasad Kottolla ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Spectral Characterization ◽  
Related Substances ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis ◽  
Mdr Tb

Synthesis and Spectral Characterization of Related Substances of Lacidipine, an Antihypertensive Drug

2009 ◽  
Vol 39 (12) ◽  
pp. 2137-2145 ◽  
Author(s):  
V. V. N. K. V. Prasada Raju ◽  
Ganta Madhusudhan Reddy ◽  
Vedantham Ravindra ◽  
Vijayavitthal T. Mathad ◽  
P. K. Dubey ◽  
...  
Keyword(s):  
Antihypertensive Drug ◽  
Spectral Characterization ◽  
Related Substances

scholarly journals Synthesis and spectral characterization of zolpidem related substances - hypnotic agent

ARKIVOC ◽  
2009 ◽  
Vol 2009 (7) ◽  
pp. 143-149 ◽  
Author(s):  
Yasareni Sumalatha ◽  
Padi Pratap Reddy ◽  
Ranga Reddy ◽  
Bollikonda Satyanarayana
Keyword(s):  
Spectral Characterization ◽  
Related Substances ◽  
Hypnotic Agent

Optimized Synthesis and Spectral Characterization of Some Hydrazones Based on 5-Nitroindazole with Pharmacological Potential

2014 ◽  
Vol 59 (3) ◽  
pp. 313-318
Author(s):  
C. Cheptea ◽  
◽  
L.M. Ivan ◽  
D.O. Dorohoi ◽  
V. Sunel ◽  
...  
Keyword(s):  
Spectral Characterization ◽  
Pharmacological Potential

Synthesis and Spectral Characterization of Derivatives of Benzotriazole and Piperidine

2018 ◽  
Vol 8 (2) ◽  
pp. 278-287
Author(s):  
Selvarathy Grace P ◽  
Ravindran Durainayagam B ◽  
Pon Matheswari P.
Keyword(s):  
Spectral Characterization ◽  
Derivatives Of

Synthesis and Spectral Characterization of New S-Alkylated 1,2,4-Triazoles as Potential Biological Agents

2017 ◽  
Vol 68 (10) ◽  
pp. 2436-2439
Author(s):  
Stefania Felicia Barbuceanu ◽  
Laura Ileana Socea ◽  
Constantin Draghici ◽  
Elena Mihaela Pahontu ◽  
Theodora Venera Apostol ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spectral Data ◽  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Ethyl Bromide ◽  
Spectral Characterization ◽  
Basic Medium ◽  
Phenacyl Bromide

In the work we presented the behavior of 5-(4-(4-X-phenylsulfonyl)phenyl)-4-(n-propyl)-2H-1,2,4-triazole-3(4H)-thiones (X= Cl or Br) with some alkylation agents. Thus, new S-alkylated 1,2,4-triazole derivatives were synthesized by reaction of the corresponding 1,2,4-triazole-3-thione derivatives with different �-halogenated compounds (ethyl bromide, ethyl chloroacetate or phenacyl bromide), in basic medium. The structures of synthesized compounds were elucidated by spectral data (1H-NMR, 13C-NMR, mass spectrometry) and elemental analysis.

Synthesis and Characterization of Potential and Degraded Impurities of Regadenoson

2020 ◽  
Vol 16 (8) ◽  
pp. 1130-1139
Author(s):  
Singaram Sathiyanarayanan ◽  
Chidambaram Subramanian Venkatesan ◽  
Senthamaraikannan Kabilan
Keyword(s):  
Mass Spectra ◽  
Degradation Products ◽  
Hplc Method ◽  
Forced Degradation ◽  
Spectroscopic Techniques ◽  
A2a Adenosine Receptor ◽  
Degradation Study ◽  
Related Substances ◽  
Adenosine Receptor Agonist

Background: Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator and commonly used as a pharmacologic cardiac stressing agents. Methods: HPLC method was used for the analysis of related substances. The degraded impurities during the process were isolated and characterized by IR, Mass and NMR spectral analysis. Results: Forced degradation study of regadenoson under conditions of hydrolysis (neutral, acidic and alkaline) and oxidations suggested in the ICH Q1A(R2) was accomplished. The drug showed significant degradation under all the above conditions. On the whole, five novel degradation products were found under diverse conditions along with process related impurities which were not reported earlier. Conclusion: All the degradation products were well characterized by using advanced spectroscopic techniques like IR, 1H NMR, 13C NMR and Mass spectra. The identification of these impurities will be productive for the quality control during the production and stability behavior of the regadenoson drug substance.

Sign in / Sign up

Export Citation Format

Share Document