The silica gel surface was alkylated by silane coupling agent KH-570 under the microwave assisted and orthogonal experiment was adopted to optimize the silica gel surface silanized experimental conditions with synthetic yield as index. With quercetin as the template molecule, 4 - vinyl pyridine as the functional monomer, ethylene glycol dimethyl acrylate as the cross linking agent, azodiisobutyronitrile as initiator, under the microwave assisted in silane silicone surface quercetin molecularly imprinted polymer was successfully synthesized. Take selected quercetin as index, another orthogonal experiment was implemented to optimize the quercetin-selective MIPs synthesis experiment on silica gel surface. What is more, the adsorptive property of quercetin-selective MIPs which was grafted on silica gel surface has been inspected. We have extracted of quercetin in the ethyl acetate from raspberry with quercetin-selective MIPs grafted on silica gel surface. Synthetic time have been shortened more than a dozen times, the efficiency of preparation of MIPs have been greatly improved.