ChemInform Abstract: Steroids from Commiphora mukul Display Antiproliferative Effect Against Human Prostate Cancer PC3 Cells via Induction of Apoptosis.

ChemInform ◽  
2012 ◽  
Vol 43 (46) ◽  
pp. no-no ◽  
Author(s):  
Tao Shen ◽  
Li Zhang ◽  
Yan-Yan Wang ◽  
Pei-Hong Fan ◽  
Xiao-Ning Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Antiproliferative Effect ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Commiphora Mukul ◽  
Pc3 Cells ◽  
Induction Of Apoptosis

Allyl Isothiocyanate Induces Autophagy through the Up-Regulation of Beclin-1 in Human Prostate Cancer Cells

2018 ◽  
Vol 46 (07) ◽  
pp. 1625-1643 ◽  
Author(s):  
Hung-En Chen ◽  
Ji-Fan Lin ◽  
Te-Fu Tsai ◽  
Yi-Chia Lin ◽  
Kuang-Yu Chou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Allyl Isothiocyanate ◽  
Beclin 1 ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Normal Prostate ◽  
Autophagy Induction ◽  
Pc3 Cells

Allyl isothiocyanate (AITC), one of the most widely studied phytochemicals, inhibits the survival of human prostate cancer cells while minimally affecting normal prostate epithelial cells. Our study demonstrates the mechanism of AITC-induced cell death in prostate cancer cells. AITC induces autophagy in RV1 and PC3 cells, judging from the increased level of LC3-II protein in a dose- and time-dependent manner, but not in the normal prostate epithelial cell (PrEC). Inhibition of autophagy in AITC-treated cells decreased cell viability and enhanced apoptosis, suggesting that the autophagy played a protective role. There are several pathways activated in ATIC-treated cells. We detected the phosphorylation forms of mTOR, ERK, AMPK, JNK and p38, and ERK AMPK and JNK activation were also detected. However, inhibition of AITC-activated ERK, AMPK and JNK by pre-treatment of specific inhibitors did not alter autophagy induction. Finally, increased beclin-1 expression was detected in AITC-treated cells, and inhibition of AITC-induced beclin-1 attanuated autophagy induction, indicating that AITC-induced autophagy occurs through upregulating beclin-1. Overall, our data show for the first time that AITC induces protective autophagy in Rv1 and PC3 cells through upregulation of beclin-1. Our results could potentially contribute to a therapeutic application of AITC in prostate cancer patients.

Inhibition of PARP1 by small interfering RNA enhances docetaxel activity against human prostate cancer PC3 cells

2013 ◽  
Vol 442 (1-2) ◽  
pp. 127-132 ◽  
Author(s):  
Wenqi Wu ◽  
Zhenzhen Kong ◽  
Xiaolu Duan ◽  
Hanliang Zhu ◽  
Shujue Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Small Interfering Rna ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Pc3 Cells ◽  
Interfering Rna

scholarly journals The Effect of Ethanol Baneh Skin Extract on the Expressions of Bcl - 2, Bax, and Caspase - 3 Concentration in Human Prostate Cancer pc3 Cells

2018 ◽  
Vol 11 (3) ◽  
Author(s):  
Maryam Amiri ◽  
Foad Nasrollahi ◽  
Siamak Barghi ◽  
Nazanin Ebrahimi ◽  
Afsaneh Rajizadeh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Caspase 3 ◽  
Human Prostate ◽  
Skin Extract ◽  
Human Prostate Cancer ◽  
Pc3 Cells
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