ChemInform Abstract: Design and Synthesis of Novel Opioid Ligands and Their Pharmacologies

Hiroshi Nagase; Hideaki Fujii

doi:10.1002/chin.201245265

The design and synthesis of kappa opioid ligands based on a binding model for kappa agonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(00)80677-0 ◽

1993 ◽

Vol 3 (5) ◽

pp. 841-846 ◽

Cited By ~ 14

Author(s):

Michael Higginbottom ◽

William Nolan ◽

John O'Toole ◽

Giles S. Ratcliffe ◽

David C. Rees ◽

...

Keyword(s):

Kappa Opioid ◽

Binding Model ◽

Opioid Ligands ◽

Design And Synthesis

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Design and Synthesis of Novel Opioid Ligands and Their Pharmacologies

Heterocycles ◽

10.3987/rev-12-738 ◽

2012 ◽

Vol 85 (8) ◽

pp. 1821 ◽

Cited By ~ 7

Author(s):

Hiroshi Nagase ◽

Hideaki Fujii

Keyword(s):

Opioid Ligands ◽

Design And Synthesis

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Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.03.001 ◽

2012 ◽

Vol 22 (8) ◽

pp. 2689-2692 ◽

Cited By ~ 5

Author(s):

Yoshikazu Watanabe ◽

Shota Kitazawa ◽

Hideaki Fujii ◽

Toru Nemoto ◽

Shigeto Hirayama ◽

...

Keyword(s):

Opioid Ligands ◽

Design And Synthesis

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Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.03.026 ◽

2013 ◽

Vol 21 (11) ◽

pp. 3032-3050 ◽

Cited By ~ 3

Author(s):

Yoshikazu Watanabe ◽

Shota Kitazawa ◽

Toru Nemoto ◽

Shigeto Hirayama ◽

Takashi Iwai ◽

...

Keyword(s):

Side Chain ◽

Opioid Ligands ◽

Design And Synthesis ◽

Amide Side Chain

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Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100115870 ◽

1975 ◽

Vol 33 ◽

pp. 450-451

Author(s):

W. Allen Shannon ◽

José A. Serrano ◽

Hannah L. Wasserkrug ◽

Anna A. Serrano ◽

Arnold M. Seligman

Keyword(s):

Acid Phosphatase ◽

Phosphate Buffer ◽

Prostatic Carcinoma ◽

Prostatic Acid Phosphatase ◽

Chemotherapeutic Agents ◽

Specific Substrate ◽

Acid Phosphate ◽

Lysosomal Acid ◽

Design And Synthesis ◽

New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

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Tailoring microstructures of materials through biomimetics

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100148332 ◽

1993 ◽

Vol 51 ◽

pp. 500-501

Author(s):

Mehmet Sarikaya ◽

Ilhan A. Aksay

Keyword(s):

Chemical Properties ◽

Design And Synthesis ◽

Structure Sensitive ◽

Macro Scale ◽

Methods Of Synthesis ◽

Successive Level ◽

Engineering Materials ◽

Physical And Chemical ◽

And Chemical Properties ◽

Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

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