ChemInform Abstract: Highly Efficient Synthesis of 3,4-Dihydro-2(1H)-quinolinone Derivatives under Microwave Heating

ChemInform ◽  
2012 ◽  
Vol 43 (45) ◽  
pp. no-no
Author(s):  
Xiao-Tong Zhu ◽  
Qiu-yun Li ◽  
Bo Jiang ◽  
Shu-Jiang Tu
Keyword(s):  
Microwave Heating ◽  
Efficient Synthesis ◽  
Highly Efficient

Highly Efficient Synthesis of 3,4-Dihydro-2(1H)-quinolinone Derivatives under Microwave Heating

Heterocycles ◽  
2012 ◽  
Vol 85 (7) ◽  
pp. 1615 ◽  
Author(s):  
Shu-Jiang Tu ◽  
Bo Jiang ◽  
Xiao-Tong Zhu ◽  
Qiu-Yun Li
Keyword(s):  
Microwave Heating ◽  
Efficient Synthesis ◽  
Highly Efficient

Highly Efficient Synthesis of Tricyclic Perimidines under Microwave Heating

2013 ◽  
Vol 50 (S1) ◽  
pp. E63-E66 ◽  
Author(s):  
Wei-Jun Zhu ◽  
Jie Ding ◽  
Bo Jiang ◽  
Shu-Jiang Tu
Keyword(s):  
Microwave Heating ◽  
Efficient Synthesis ◽  
Highly Efficient

Highly efficient synthesis of methyl ethyl ketone oxime through ammoximation over Ti-MOR catalyst

2014 ◽  
Vol 34 (1) ◽  
pp. 243-250
Author(s):  
Jianghong DING ◽  
Le XU ◽  
Hao XU ◽  
Haihong WU ◽  
Yueming LIU ◽  
...  
Keyword(s):  
Methyl Ethyl Ketone ◽  
Methyl Ethyl ◽  
Efficient Synthesis ◽  
Highly Efficient

Advanced Heterocyclic Branched Semiconducting Units - Highly Efficient Synthesis and Physicochemical Characteristic

2013 ◽  
Vol 17 (3) ◽  
pp. 283-295 ◽  
Author(s):  
Jadwiga Soloducho ◽  
Joanna Cabaj ◽  
Kamila Olech ◽  
Przemyslaw Data ◽  
Mieczyslaw Lapkowski
Keyword(s):  
Physicochemical Characteristic ◽  
Efficient Synthesis ◽  
Highly Efficient

Hafnium(IV) Chloride Catalyzes Highly Efficient Acetalization of Carbonyl Compounds

2019 ◽  
Vol 16 (6) ◽  
pp. 913-920 ◽  
Author(s):  
Israel Bonilla-Landa ◽  
Emizael López-Hernández ◽  
Felipe Barrera-Méndez ◽  
Nadia C. Salas ◽  
José L. Olivares-Romero
Keyword(s):  
Microwave Heating ◽  
Reaction Times ◽  
Protecting Groups ◽  
Catalyst Loading ◽  
Selective Protection ◽  
Highly Efficient ◽  
Aldehydes And Ketones ◽  
High Yields ◽  
Novel Catalyst ◽  
Acid Labile

Background: Hafnium(IV) tetrachloride efficiently catalyzes the protection of a variety of aldehydes and ketones, including benzophenone, acetophenone, and cyclohexanone, to the corresponding dimethyl acetals and 1,3-dioxolanes, under microwave heating. Substrates possessing acid-labile protecting groups (TBDPS and Boc) chemoselectively generated the corresponding acetal/ketal in excellent yields. Aim and Objective: In this study. the selective protection of aldehydes and ketones using a Hafnium(IV) chloride, which is a novel catalyst, under microwave heating was observed. Hence, it is imperative to find suitable conditions to promote the protection reaction in high yields and short reaction times. This study was undertaken not only to find a novel catalyst but also to perform the reaction with substrates bearing acid-labile protecting groups, and study the more challenging ketones as benzophenone. Materials and Methods: Using a microwave synthesis reactor Monowave 400 of Anton Paar, the protection reaction was performed on a raging temperature of 100°C ±1, a pressure of 2.9 bar, and an electric power of 50 W. More than 40 substrates have been screened and protected, not only the aldehydes were protected in high yields but also the more challenging ketones such as benzophenone were protected. All the products were purified by simple flash column chromatography, using silica gel and hexanes/ethyl acetate (90:10) as eluents. Finally, the protected substrates were characterized by NMR 1H, 13C and APCI-HRMS-QTOF. Results: Preliminary screening allowed us to find that 5 mol % of the catalyst is enough to furnish the protected aldehyde or ketone in up to 99% yield. Also it was found that substrates with a variety of substitutions on the aromatic ring (aldehyde or ketone), that include electron-withdrawing and electrondonating group, can be protected using this methodology in high yields. The more challenging cyclic ketones were also protected in up to 86% yield. It was found that trimethyl orthoformate is a very good additive to obtain the protected acetophenone. Finally, the protection of aldehydes with sensitive functional groups was performed. Indeed, it was found that substrates bearing acid labile groups such as Boc and TBDPS, chemoselectively generated the corresponding acetal/ketal compound while keeping the protective groups intact in up to 73% yield. Conclusion: Hafnium(IV) chloride as a catalyst provides a simple, highly efficient, and general chemoselective methodology for the protection of a variety of structurally diverse aldehydes and ketones. The major advantages offered by this method are: high yields, low catalyst loading, air-stability, and non-toxicity.

Highly Efficient Synthesis of Clean Biofuels from Biomass Using FeCuZnAlK Catalyst

2011 ◽  
Vol 24 (6) ◽  
pp. 745-752 ◽  
Author(s):  
Song-bai Qiu ◽  
Yong Xu ◽  
Tong-qi Ye ◽  
Fei-yan Gong ◽  
Zhi Yang ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Highly Efficient

Sustainable production of γ-valerolactone and δ-valerolactone through the coupling of hydrogenation and dehydrogenation

2021 ◽  
Author(s):  
Hongxing Wang ◽  
Guoqiang Ding ◽  
Xianqing Li ◽  
Haohao She ◽  
Yulei Zhu ◽  
...  
Keyword(s):  
Sustainable Production ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
Catalytic Processes ◽  
Lignocellulose Biomass

γ-valerolactone (GVL) and δ-valerolactone (DVL) are valuable chemicals that can be obtained by catalytic processes from nonedible lignocellulose biomass. However, highly efficient synthesis of GVL and DVL in an environmentally...

Highly efficient synthesis of 5-hydroxymethylfurfural with carbohydrates over renewable cyclopentanone-based acidic resin

2017 ◽  
Vol 19 (8) ◽  
pp. 1855-1860 ◽  
Author(s):  
Hao Tang ◽  
Ning Li ◽  
Fang Chen ◽  
Guangyi Li ◽  
Aiqin Wang ◽  
...  
Keyword(s):  
Reusable Catalyst ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
Acidic Resin

A sulfated cyclopentanone-formaldehyde condensate was found to be an effective and reusable catalyst for the dehydration of fructose to 5-hydroxymethylfurfural (HMF).

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