ChemInform Abstract: Novel Acridinedione Derivatives: Design, Synthesis, SIRT1 Enzyme and Tumor Cell Growth Inhibition Studies.

ChemInform ◽  
2012 ◽  
Vol 43 (38) ◽  
pp. no-no
Author(s):  
Mallika Alvala ◽  
Shubhmita Bhatnagar ◽  
Alvala Ravi ◽  
Variam Ullas Jeankumar ◽  
Thimmappa H. Manjashetty ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition ◽  
Design Synthesis ◽  
Inhibition Studies

Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies

2012 ◽  
Vol 22 (9) ◽  
pp. 3256-3260 ◽  
Author(s):  
Mallika Alvala ◽  
Shubhmita Bhatnagar ◽  
Alvala Ravi ◽  
Variam Ullas Jeankumar ◽  
Thimmappa H Manjashetty ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition ◽  
Design Synthesis ◽  
Inhibition Studies

Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors

2009 ◽  
Vol 17 (16) ◽  
pp. 5900-5905 ◽  
Author(s):  
Takayoshi Suzuki ◽  
Keiko Imai ◽  
Erika Imai ◽  
Shinsuke Iida ◽  
Ryuzo Ueda ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Enzyme Inhibition ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition ◽  
Design Synthesis

Chiral derivatives of xanthones and benzophenones: Synthesis, enantioseparation, molecular docking, and tumor cell growth inhibition studies

Chirality ◽  
2021 ◽  
Author(s):  
Ye' Zaw Phyo ◽  
Joana Teixeira ◽  
Ricardo Gonçalves ◽  
Andreia Palmeira ◽  
Maria Elizabeth Tiritan ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition ◽  
Inhibition Studies ◽  
Derivatives Of

Synthesis, characterization and tumor cell growth inhibition of new trans platinum complexes with phosphane derivatives

Polyhedron ◽  
2011 ◽  
Vol 30 (10) ◽  
pp. 1646-1650 ◽  
Author(s):  
A.G. Quiroga ◽  
F.J. Ramos-Lima ◽  
A. Alvarez-Valdés ◽  
M. Font-Bardía ◽  
A. Bergamo ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Platinum Complexes ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition

Tumor Cell Growth Inhibition by Liposome-Encapsulated Aromatic Polyamidines

1990 ◽  
Vol 79 (8) ◽  
pp. 672-677 ◽  
Author(s):  
C. Nastruzzi ◽  
R. Gambari ◽  
E. Menegatti ◽  
P. Walde ◽  
P.L. Luisi
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition

scholarly journals In Vitro Tumor Cell Growth Inhibition Induced by Lophocereus marginatus (DC.) S. Arias and Terrazas Endophytic Fungi Extracts

2021 ◽  
Vol 18 (18) ◽  
pp. 9917
Author(s):  
Jesica M. Ramírez-Villalobos ◽  
César I. Romo-Sáenz ◽  
Karla S. Morán-Santibañez ◽  
Patricia Tamez-Guerra ◽  
Ramiro Quintanilla-Licea ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Endophytic Fungi ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition ◽  
Antitumor Effects ◽  
Ht 29 ◽  
Mcf 7

Endophytic fungi have become potential sources of antitumor agents, particularly against antineoplastic-resistant cancer cells, with marginal or nil adverse effects for the oncological patient. Endophytic fungi were isolated from stems of the Lophocereus marginatus cactus, commonly found in Mexico. Methanol extracts were then obtained from fungus liquid cultures and their effects on tumor cell growth against murine lymphoma (L5178Y-R), human colorectal adenocarcinoma (HT-29), and human breast cancer (MCF-7) cells were evaluated at concentrations ranging from 31 µg/mL to 250 µg/mL via the colorimetric 3- [4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide reduction assay, using monkey kidney epithelial (MA-104) and human peripheral mononuclear (PBMC) cells as controls. Furthermore, we obtained the IC50 and the selectivity index (SI) was calculated from the IC50 ratio of normal and tumor cells. In addition, molecular identification of fungi showing cytotoxic activity was determined, using internal transcribed spacer molecular markers. PME-H001, PME-H002, PME-H005, PME-H007, and PME-H008 filamentous fungus strain extracts showed significant (p < 0.05) tumor cell growth inhibition. In particular, they significantly (p < 0.05) inhibited L5178Y-R cell growth, whereas the least susceptible cell line was HT-29. The endophytic strain PME-H008 of Cladosporium sp. caused the highest growth inhibition percentage against L5178Y-R and HT-29 cells with 96.6% (p < 0.01) and 42.5% (p < 0.05) respectively, and the highest SIs against L5178Y-R cells with 2.4 and 2.9 for MA-104 and PBMCs, respectively, whereas the PME-H005 extract showed SIs of 2.77 and 1.5 against MCF-7 and L5178Y-R cells, respectively, as compared with PBMCs. In addition, the endophytic strain PME-H007 of Metarhizium anisopliae caused the highest percentage of growth inhibition (p < 0.01) against MCF-7 cells with 55.8% at 250 µg/mL. We demonstrated in vitro antitumor effects of L. marginatus endophytic fungi. Further research will involve the isolation and in vivo testing of bioactive compounds.

Butyltin(IV) Benzoates: Inhibition of Thioredoxin Reductase, Tumor Cell Growth Inhibition, and Interactions with Proteins

ChemMedChem ◽  
2012 ◽  
Vol 8 (2) ◽  
pp. 256-264 ◽  
Author(s):  
Kely Navakoski de Oliveira ◽  
Vincent Andermark ◽  
Susanne von Grafenstein ◽  
Liliane A. Onambele ◽  
Gregor Dahl ◽  
...  
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Growth Inhibition ◽  
Thioredoxin Reductase ◽  
Tumor Cell Growth ◽  
Cell Growth Inhibition
Sign in / Sign up

Export Citation Format

Share Document