ChemInform Abstract: An Efficient Method for the Preparation of Mono α-Aryl Derivatives of Diethyl Malonate and Ethyl Cyanoacetate Using Ethyl-1-imidazole Carbamate (EImC).

ChemInform ◽  
2012 ◽  
Vol 43 (25) ◽  
pp. no-no
Author(s):  
Manoranjan Behera ◽  
R. Venkat Ragavan ◽  
M. Sambaiah ◽  
Balaiah Erugu ◽  
J. Rama Krishna Reddy ◽  
...  
Keyword(s):  
Efficient Method ◽  
Ethyl Cyanoacetate ◽  
Diethyl Malonate ◽  
Derivatives Of

An efficient method for the preparation of mono α-aryl derivatives of diethyl malonate and ethyl cyanoacetate using ethyl-1-imidazole carbamate (EImC)

2012 ◽  
Vol 53 (9) ◽  
pp. 1060-1062 ◽  
Author(s):  
Manoranjan Behera ◽  
R. Venkat Ragavan ◽  
M. Sambaiah ◽  
Balaiah Erugu ◽  
J. Rama Krishna Reddy ◽  
...  
Keyword(s):  
Efficient Method ◽  
Ethyl Cyanoacetate ◽  
Diethyl Malonate ◽  
Derivatives Of

Use of malonic acid derivatives for the construction of substituted side chains in the position 17β of steroids

1982 ◽  
Vol 47 (4) ◽  
pp. 1240-1251 ◽  
Author(s):  
Pavel Drašar ◽  
Vladimír Pouzar ◽  
Ivan Černý ◽  
Miroslav Havel ◽  
Sofia N. Ananchenko ◽  
...  
Keyword(s):  
Malonic Acid ◽  
Ethyl Cyanoacetate ◽  
Diethyl Malonate ◽  
Side Chain ◽  
Knoevenagel Reaction ◽  
Side Chains ◽  
Condensation Products ◽  
Malonic Acid Derivatives ◽  
Derivatives Of ◽  
Dioxane Ring

Using the Knoevenagel reaction condensation products of 3β-acetoxyandrost-5-en-17-one with diethyl malonate, ethyl cyanoacetate and malononitrile were prepared which converted to derivatives of 3β-hydroxypregn-5-en-21-oic acid. Reductions and oxidations of the double bonds in the positions 5,6 and 17,20 and the stereochemistry at atoms C(17) and C(20) of some derivatives were also investigated. From derivatives of 23,24-dinorchola-5,17(20)-diene-21,22-diol compounds with a 1,3-dioxane ring in the side chain were prepared.

Reactions of 3-cyano-1-methylquinolinium methyl sulphate with some C-acids and with p-nitroaniline

1981 ◽  
Vol 46 (2) ◽  
pp. 503-505 ◽  
Author(s):  
Oldřich Kocián ◽  
Miloslav Ferles
Keyword(s):  
Sodium Methoxide ◽  
Ethyl Cyanoacetate ◽  
Derivatives Of

The action of malononitrile, ethyl cyanoacetate, dibenzoylmethane and/or p-nitroaniline on compound I in the presence of sodium methoxide gives rise to derivatives of 3-cyano-1-methyl-1,4-dihydroquinoline, II and III

A mild and efficient chemoselective N-benzyloxycarbonylation of amines using TBAB as a catalyst under solvent-free conditions

2009 ◽  
Vol 87 (2) ◽  
pp. 393-396 ◽  
Author(s):  
Kothamasu Suresh Babu ◽  
Vidadala Rama Subba Rao ◽  
Ravu Ranga Rao ◽  
Sakhamuri Sivaram Babu ◽  
Janaswami Madhusudana Rao
Keyword(s):  
Efficient Method ◽  
Aromatic Amines ◽  
Solvent Free ◽  
Solvent Free Conditions ◽  
Derivatives Of

We describe a mild and efficient method for the chemoselective N-benzyloxycarbonylation of amines by treatment of amines and aminoesters with benzyloxycarbonyl chloride (Cbz-Cl) in the presence of TBAB under solvent-free conditions in excellent yields. The method is general for the preparation of a wide variety of N-Cbz derivatives of aliphatic, aromatic amines, and aminoesters.

scholarly journals Kinase Inhibitors of Novel Pyridopyrimidinone Candidates: Synthesis and In Vitro Anticancer Properties

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Nagy M. Khalifa ◽  
Mohamed A. Al-Omar ◽  
Hamad M. Alkahtani ◽  
Ahmed H. Bakheit
Keyword(s):  
Kinase Inhibitors ◽  
Human Cancer ◽  
Ethyl Cyanoacetate ◽  
Diethyl Malonate ◽  
Aromatic Aldehydes ◽  
Docking Studies ◽  
Braf V600e ◽  
Kinase Assay ◽  
Human Cancer Cell Lines

A new class of pyridopyrimidinone compounds containing different nitrogenous heterocycles were synthesized starting from the key precursor 2-hydrazinyl-5-phenyl-7-(pyridin-3-yl)pyrido[2,3-d]pyrimidin-4(3H)-one via condensation with series of aromatic aldehydes and cyclization using different reagents as ethyl acetoacetate, ethyl cyanoacetate, diethyl malonate, and ammonium isothiocyanate. The bioassay results showed compound 6 to be highly effective towards three human cancer cell lines (HepG2, PC-3, and HCT-116) in vitro with promising activity values (IC50: 0.5 μM) relative to the standard doxorubicin (IC50: 0.6 μM). Kinase inhibitory evaluation of compound 6 displays hopeful inhibitory action against BRAF V600E, EGFR, and PDGFRβ at100 μM. The molecular docking studies supported the initial kinase assay.

scholarly journals A Simple and Efficient Tensor Calculus

2020 ◽  
Vol 34 (04) ◽  
pp. 4527-4534
Author(s):  
Sören Laue ◽  
Matthias Mitterreiter ◽  
Joachim Giesen
Keyword(s):  
Machine Learning ◽  
Efficient Method ◽  
Automatic Differentiation ◽  
State Of The Art ◽  
Higher Order ◽  
Tensor Representation ◽  
Tensor Calculus ◽  
Correct Algorithm ◽  
Previous State ◽  
Derivatives Of

Computing derivatives of tensor expressions, also known as tensor calculus, is a fundamental task in machine learning. A key concern is the efficiency of evaluating the expressions and their derivatives that hinges on the representation of these expressions. Recently, an algorithm for computing higher order derivatives of tensor expressions like Jacobians or Hessians has been introduced that is a few orders of magnitude faster than previous state-of-the-art approaches. Unfortunately, the approach is based on Ricci notation and hence cannot be incorporated into automatic differentiation frameworks like TensorFlow, PyTorch, autograd, or JAX that use the simpler Einstein notation. This leaves two options, to either change the underlying tensor representation in these frameworks or to develop a new, provably correct algorithm based on Einstein notation. Obviously, the first option is impractical. Hence, we pursue the second option. Here, we show that using Ricci notation is not necessary for an efficient tensor calculus and develop an equally efficient method for the simpler Einstein notation. It turns out that turning to Einstein notation enables further improvements that lead to even better efficiency.

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