ChemInform Abstract: Melamine as a Green and Reusable Catalyst for Knoevenagel Condensation at Room Temperature under Solvent-Free Conditions.

ChemInform ◽  
2012 ◽  
Vol 43 (22) ◽  
pp. no-no
Author(s):  
Xian-Cao Yang ◽  
Hong Jiang ◽  
Wen Ye
Keyword(s):  
Room Temperature ◽  
Knoevenagel Condensation ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
Solvent Free Conditions

scholarly journals A Solvent-Free Protocol for the Green Synthesis of 5-Arylidene-2,4-thiazolidinediones Using Ethylenediamine Diacetate as Catalyst

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Yuliang Zhang ◽  
Zhongqiang Zhou
Keyword(s):  
Knoevenagel Condensation ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Work Up ◽  
Solvent Free Reaction

A simple and efficient synthesis of 5-arylidene-2,4-thiazolidinediones by the Knoevenagel condensation of aromatic aldehydes with 2,4-thiazolidinedione catalyzed by ethylenediamine diacetate under solvent-free conditions is described. The major advantages of this method are simple experimental and work-up procedures, solvent-free reaction conditions, small amount of catalyst, short reaction time, high yields, and utilization of an inexpensive and reusable catalyst.

Nano-SiO2: a heterogeneous and reusable catalyst for the one-pot synthesis of symmetrical and unsymmetrical 3,3-di(aryl)indolin-2-ones under solvent-free conditions

2016 ◽  
Vol 71 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Kobra Nikoofar ◽  
Zahra Khalili
Keyword(s):  
Room Temperature ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
One Pot ◽  
Nano Sio2 ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Magnetic Stirring ◽  
Plausible Mechanism ◽  
The One

AbstractSymmetrical and unsymmetrical 3,3-di(aryl)indolin-2-ones have been synthesized by nano-SiO2 as green, heterogeneous, and reusable catalyst under solvent-free conditions at room temperature via magnetic stirring and grinding methods. A plausible mechanism of condensation has also been presented.

ZnO-nanorods Promoted Synthesis of α-amino Nitrile Benzofuran Derivatives using One-pot Multicomponent Reaction of Isocyanides

2020 ◽  
Vol 23 (4) ◽  
pp. 345-355
Author(s):  
Asef H. Najar ◽  
Zinatossadat Hossaini ◽  
Shahrzad Abdolmohammadi ◽  
Daryoush Zareyee
Keyword(s):  
Multicomponent Reaction ◽  
Room Temperature ◽  
Solvent Free ◽  
Primary Amines ◽  
Reusable Catalyst ◽  
Reaction Conditions ◽  
Trimethylsilyl Cyanide ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Amino Nitrile

Aims & Objective: In this work ZnO-nanorod (ZnO-NR) as reusable catalyst promoted Strecker-type reaction of 2,4-dihydroxyacetophenone, isopropenylacetylene, trimethylsilyl cyanide (TMSCN), primary amines and isocyanides at ambient temperature under solvent-free conditions and produced α-amino nitriles benzofuran derivatives in high yields. These synthesized compounds may have antioxidant ability. Materials and Methods: ZnO-NRs in these reactions were prepared according to reported article. 2,4-dihydroxyacetophenone 1 (2 mmol) and isopropenylacetylene 2 (2 mmol) were mixed and stirred for 30 min in the presence of ZnO-NR (10 mol%) under solvent-free conditions at room temperature. After 30 min, primary amine 3 (2 mmol) was added to the mixture gently and the mixture was stirred for 15 min. After this time TMSCN 4 (2 mmol) was added to the mixture and stirred for 15 min. After completion of the reaction, as indicated by TLC, isocyanides 5 was added to mixture in the presence of catalyst. Results: In the first step of this research, the reaction of 2,4-dihydroxyacetophenone 1, isopropenylacetylene 2, methyl amine 3a, trimethylsilyle cyanide 4 and tert-butyl isocyanides 5a was used as a sample reaction to attain the best reaction conditions. The results showed this reaction performed with catalyst and did not have any product without catalyst after 12 h. Conclusion: In conclusion, we investigate multicomponent reaction of 2,4-dihydroxyacetophenone 1, isopropenylacetylene 2, primary amines 3, trimethylsilyl cyanide 4 and isocyanides along with ZnO-NRs as reusable catalyst at room temperature under solvent-free conditions which generates α-amino nitrile benzofuran derivatives in high yields. The advantages of our method are high atom economy, green reaction conditions, higher yield, shorter reaction times, and easy work-up, which are in good agreement with some principles of green chemistry. The compounds 8c exhibit excellent DPPH radical scavenging activity and FRAP compared to synthetic antioxidants BHT and TBHQ.

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