ChemInform Abstract: Activation of Allenes by Gold Complexes: A Theoretical Standpoint

ChemInform ◽  
2012 ◽  
Vol 43 (14) ◽  
pp. no-no
Author(s):  
Max Malacria ◽  
Louis Fensterbank ◽  
Vincent Gandon
Keyword(s):  
Gold Complexes ◽  
Theoretical Standpoint

Electronmicroscopic localization of ribonucleic acids in ciliate Bursaria truncatella during cell division

1990 ◽  
Vol 48 (3) ◽  
pp. 132-133
Author(s):  
Vladimir Popenko ◽  
Natalya Cherny ◽  
Maria Yakovleva
Keyword(s):  
Cell Division ◽  
High Specificity ◽  
Longitudinal Axis ◽  
Gold Complexes ◽  
Somatic Nucleus ◽  
Ribonucleic Acids ◽  
Biological Meaning ◽  
Bivalent Cations ◽  
Lowicryl K4m ◽  
Short Time

Highly polyploid somatic nucleus (macronucleus) of ciliate Bursaria truncatella under goes severe changes in morphology during cell division. At first, macronucleus (Ma) condences, diminishes in size and turns perpendicular to longitudinal axis of the cell. After short time, Ma turns again, elongates and only afterwards the process of division itself occurs. The biological meaning of these phenomena is not clear.Localization of RNA in the cells was performed on sections of ciliates B. truncatella, embedded in “Lowicryl K4M” at various stages: (1) before cell division (Figs. 2,3); (11) at the stage of macronucleus condensation; (111) during elongation of Ma (Fig.4); (1111) in young cells (0-5min. after division). For cytochemical labelling we used RNaseAcolloidal gold complexes (RNase-Au), which are known to bind to RNA containing cell ularstructures with high specificity. The influence of different parameters on the reliability and reproducibility of labelling was studied. In addition to the factors, discussed elsewhere, we found that the balance of mono- and bivalent cations is of great significance.

Competition and Commercialisation of Microfinance Institutions: Implications for the Sector

Think India ◽  
2018 ◽  
Vol 21 (2) ◽  
pp. 1-16
Author(s):  
Joyeeta Deb
Keyword(s):  
Low Income ◽  
Development Programme ◽  
Microfinance Institutions ◽  
Dependent Development ◽  
Social Mission ◽  
Low Income Population ◽  
Development Institutions ◽  
Potential Impact ◽  
Intensity Of Competition ◽  
Theoretical Standpoint

Until 1990s microfinance was mainly seen as an impact – driven development programme based on the support of government and private donors. However, the failure of many subsidy dependent development institutions advocated for microfinance institutions to be self-sufficient and sustainable. This prompted MFIs to be commercially oriented and profit motivated. Also, with the growing proliferation of new providers of microcredit and influx of commercial investment in the sector, there is an increasing intensity of competition in the sector. Increased competition coupled with commercialisation helped in integrating the low-income population into a more formal financial system. But critics view that, this process has led the MFIs to search for better off clientele, thereby in many cases, departing from their social mission. Increasing competition followed by saturation in the sector has led to the mission drift of MFIs and has become a major cause of concern globally. However, some view this process to be a “win-win’ scenario whereby there exists scope for widening outreach and attaining sustainability. The present paper is devoted to examine the process of commercialisation and gauge the potential impact of competition and commercialisation of microfinance institutions on MFI performance from a theoretical standpoint.

scholarly journals Emerging Molecular Receptors for the Specific-Target Delivery of Ruthenium and Gold Complexes into Cancer Cells

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3153
Author(s):  
João Franco Machado ◽  
João D. G. Correia ◽  
Tânia S. Morais
Keyword(s):  
Progesterone Receptors ◽  
Biological Evaluation ◽  
Cell Organelles ◽  
Gold Complexes ◽  
Main Research ◽  
Wide Range ◽  
Cancer Types ◽  
Organometallic Molecules ◽  
G Protein Coupled

Cisplatin and derivatives are highly effective in the treatment of a wide range of cancer types; however, these metallodrugs display low selectivity, leading to severe side effects. Additionally, their administration often results in the development of chemoresistance, which ultimately results in therapeutic failure. This scenario triggered the study of other transition metals with innovative pharmacological profiles as alternatives to platinum, ruthenium- (e.g., KP1339 and NAMI-A) and gold-based (e.g., Auranofin) complexes being among the most advanced in terms of clinical evaluation. Concerning the importance of improving the in vivo selectivity of metal complexes and the current relevance of ruthenium and gold metals, this review article aims to survey the main research efforts made in the past few years toward the design and biological evaluation of target-specific ruthenium and gold complexes. Herein, we give an overview of the inorganic and organometallic molecules conjugated to different biomolecules for targeting membrane proteins, namely cell adhesion molecules, G-protein coupled receptors, and growth factor receptors. Complexes that recognize the progesterone receptors or other targets involved in metabolic pathways such as glucose transporters are discussed as well. Finally, we describe some complexes aimed at recognizing cell organelles or compartments, mitochondria being the most explored. The few complexes addressing targeted gene therapy are also presented and discussed.

Gold complexes of bis-indazole-derived N-Heterocyclic carbene: Synthesis, structural characterizations, and catalysis

2021 ◽  
Vol 1233 ◽  
pp. 130043
Author(s):  
Hua Zhang ◽  
Ting Xu ◽  
Dongdong Li ◽  
Tao Cheng ◽  
Jing Chen ◽  
...  
Keyword(s):  
Gold Complexes ◽  
Structural Characterizations

scholarly journals Ethical dilemmas are really important to potential adopters of autonomous vehicles

2021 ◽  
Author(s):  
Tripat Gill
Keyword(s):  
Autonomous Vehicles ◽  
Ethical Issues ◽  
Social Dilemma ◽  
Innovation Adoption ◽  
Preliminary Evidence ◽  
Policy Makers ◽  
Early Adopters ◽  
The Social ◽  
Legal And Ethical Issues ◽  
Theoretical Standpoint

AbstractThe ethical dilemma (ED) of whether autonomous vehicles (AVs) should protect the passengers or pedestrians when harm is unavoidable has been widely researched and debated. Several behavioral scientists have sought public opinion on this issue, based on the premise that EDs are critical to resolve for AV adoption. However, many scholars and industry participants have downplayed the importance of these edge cases. Policy makers also advocate a focus on higher level ethical principles rather than on a specific solution to EDs. But conspicuously absent from this debate is the view of the consumers or potential adopters, who will be instrumental to the success of AVs. The current research investigated this issue both from a theoretical standpoint and through empirical research. The literature on innovation adoption and risk perception suggests that EDs will be heavily weighted by potential adopters of AVs. Two studies conducted with a broad sample of consumers verified this assertion. The results from these studies showed that people associated EDs with the highest risk and considered EDs as the most important issue to address as compared to the other technical, legal and ethical issues facing AVs. As such, EDs need to be addressed to ensure robustness in the design of AVs and to assure consumers of the safety of this promising technology. Some preliminary evidence is provided about interventions to resolve the social dilemma in EDs and about the ethical preferences of prospective early adopters of AVs.

Dinuclear N-Heterocyclic Dicarbene Gold Complexes in I–III and III–III Oxidation States: Synthesis and Structural Analysis

2011 ◽  
Vol 30 (17) ◽  
pp. 4607-4615 ◽  
Author(s):  
Marco Baron ◽  
Cristina Tubaro ◽  
Marino Basato ◽  
Andrea Biffis ◽  
Marta M. Natile ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Oxidation States ◽  
Gold Complexes
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