ChemInform Abstract: Silicon-Mediated Direct Conversion of Acyl Chlorides to Carbamoyl Azides or/and Tetrazolinones under Mild Conditions.

ChemInform ◽  
2012 ◽  
Vol 43 (10) ◽  
pp. no-no
Author(s):  
Tarek A. Salama ◽  
Saad S. Elmorsy ◽  
Abdel-Galil M. Khalil ◽  
Mohamed A. Ismail
Keyword(s):  
Direct Conversion ◽  
Acyl Chlorides ◽  
Mild Conditions

Silicon-mediated Direct Conversion of Acyl Chlorides to Carbamoyl Azides or/and Tetrazolinones under Mild Conditions

2011 ◽  
Vol 40 (10) ◽  
pp. 1149-1151 ◽  
Author(s):  
Tarek A. Salama ◽  
Saad S. Elmorsy ◽  
Abdel-Galil M. Khalil ◽  
Mohamed A. Ismail
Keyword(s):  
Direct Conversion ◽  
Acyl Chlorides ◽  
Mild Conditions

Organophosphane-Catalyzed Construction of Functionalized 2-Ylideneoxindoles via Direct β-Acylation

Synthesis ◽  
2021 ◽  
Author(s):  
Wey-Chyng Jeng ◽  
Po-Chung Chien ◽  
Sandip Sambhaji Vagh ◽  
Athukuri Edukondalu ◽  
Wenwei Lin
Keyword(s):  
Intramolecular Cyclization ◽  
Efficient Method ◽  
Bond Cleavage ◽  
Scale Up ◽  
Acyl Chlorides ◽  
Metal Free ◽  
Mild Conditions ◽  
Synthetic Utility ◽  
Mechanistic Investigations ◽  
Synthetic Transformations

We report an efficient method for the direct β-acylation of 2-ylideneoxindoles with acyl chlorides in the presence of base-catalyzed by organophosphanes. A variety of functionalized 2-ylideneoxindoles were prepared in moderate to good yields under metal-free and mild conditions via a tandem phospha-Michael/O-acylation/intramolecular cyclization/ rearrangement sequence. The mechanistic investigations revealed that the C-O bond cleavage on possible betaine intermediate is the key step for the installation of keto-functionality at β-position of 2-ylideneoxindoles in a highly stereospecific manner. The synthetic utility of this protocol could also be proven by scale-up reactions and synthetic transformations of the products.

Direct conversion of cellulose into glycolic acid by a zinc-stabilized UV-Fenton reaction

RSC Advances ◽  
2015 ◽  
Vol 5 (8) ◽  
pp. 5741-5744 ◽  
Author(s):  
Z. She ◽  
J. G. Wang ◽  
J. P. Ni ◽  
X. Q. Liu ◽  
R. Y. Zhang ◽  
...  
Keyword(s):  
Fenton Reaction ◽  
Glycolic Acid ◽  
Direct Conversion ◽  
Mild Conditions

Direct conversion of cellulose into glycolic acid at mild conditions was realized by a zinc-stabilized UV-Fenton reaction.

Consecutive Multicomponent Reactions: Synthesis of 3-Acyl-4-alkynyl-Substituted 1,3-Thiazolidines

Synthesis ◽  
2018 ◽  
Vol 50 (05) ◽  
pp. 1123-1132 ◽  
Author(s):  
Jürgen Martens ◽  
Torben Schlüter ◽  
Nils Frerichs ◽  
Marc Schmidtmann
Keyword(s):  
Functional Groups ◽  
Multicomponent Reactions ◽  
Terminal Alkynes ◽  
Synthetic Route ◽  
Acyl Chlorides ◽  
Mild Conditions ◽  
Three Component Reaction

This work describes the synthesis of compounds containing thiazolidine and propargylamidic motifs. Their preparation follows a synthetic route containing two multicomponent reactions. First, the Asinger four-component reaction is used to prepare 3-thiazolines and 3-oxazolines. Secondly, these heterocyclic imines are converted into propargylamides by a copper-catalyzed three-component reaction using acyl chlorides and terminal alkynes. The synthetic route is characterized by mild conditions and many functional groups are tolerated. The formation of an unexpected α-alkynoxyamide is also presented.

Gram-scale Preparation of Acyl Fluorides and Their Reactions with Hindered Nucleophiles

Synthesis ◽  
2021 ◽  
Author(s):  
Michał Tryniszewski ◽  
Michal Barbasiewicz
Keyword(s):  
Phase Transfer ◽  
Lithium Amide ◽  
Acyl Chlorides ◽  
Mild Conditions ◽  
Convenient Procedure ◽  
Halogen Exchange ◽  
Scale Preparation ◽  
Biphasic Mixture ◽  
Sterically Hindered

A series of acyl fluorides was synthesized at 100 mmol scale using phase transfer catalyzed halogen exchange between acyl chlorides and aqueous bifluoride solution. The convenient procedure consists of vigorous stirring of the biphasic mixture at rt, followed by extraction and distillation. Isolated acyl fluorides (usually 7 g to 20 g) display excellent purity, and can be transformed into sterically hindered amides and esters, when treated with lithium amide bases and alkoxides under mild conditions.

scholarly journals Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

RSC Advances ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 2199-2204 ◽  
Author(s):  
Chuan-Tao Zhang ◽  
Rui Zhu ◽  
Zheng Wang ◽  
Bing Ma ◽  
Adrian Zajac ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Parallel Synthesis ◽  
Grignard Reagents ◽  
Acyl Chlorides ◽  
Flow Synthesis ◽  
Flow Method ◽  
Mild Conditions ◽  
Continuous Flow Method

Continuous flow method for parallel synthesis of diaryl ketones using commercially available reagents.

A Multifunctional Reagent Designed for the Site-Selective Amination of Pyridines

2020 ◽  
Author(s):  
Patrick Fier ◽  
Suhong Kim ◽  
Ryan Cohen
Keyword(s):  
Reaction Mechanism ◽  
Direct Conversion ◽  
Single Step ◽  
The Novel ◽  
Title Reaction ◽  
Mild Conditions ◽  
Unique Reaction ◽  
Unexpected Findings ◽  
Site Selective

We report the development of a multifunctional reagent for the direct conversion of pyridines to Boc-protected 2-aminopyridines with exquisite site- and chemoselectivity. The novel reagent was prepared on 200 gram-scale in a single step, reacts in the title reaction under mild conditions without precautions towards air or moisture, and is tolerant of nearly all common functionality. Experimental and <i>in-situ </i>spectroscopic<i> </i>monitoring techniques provide detailed insights and unexpected findings for the unique reaction mechanism.

scholarly journals DIRECT CONVERSION OF CARBOXYLIC ACIDS INTO ACYL CHLORIDES AND ESTERS USING 9-CHLOROACRIDINE

1972 ◽  
Vol 1 (3) ◽  
pp. 207-208 ◽  
Author(s):  
Hiroo Inoue ◽  
Shin-ichi Kawahara ◽  
Eiji Imoto
Keyword(s):  
Carboxylic Acids ◽  
Direct Conversion ◽  
Acyl Chlorides
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