ChemInform Abstract: Novel Trinitrogen-Containing Triheterocycles via the Intramolecular Nitrile Oxide Cycloaddition Reaction.

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Andrew J. Ferreira ◽  
Danielle M. Solano ◽  
James S. Oakdale ◽  
Mark J. Kurth
Keyword(s):  
Cycloaddition Reaction ◽  
Nitrile Oxide

scholarly journals Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C–H arylation

2016 ◽  
Vol 14 (25) ◽  
pp. 5983-5991 ◽  
Author(s):  
Jian-Siang Poh ◽  
Cristina García-Ruiz ◽  
Andrea Zúñiga ◽  
Francesca Meroni ◽  
David C. Blakemore ◽  
...  
Keyword(s):  
Cycloaddition Reaction ◽  
Building Blocks ◽  
Nitrile Oxide

We report conditions for the preparation of a range of trifluoromethylated isoxazole building blocks through the cycloaddition reaction of trifluoromethyl nitrile oxide and their subsequent derivatisation.

A Novel Synthesis of Benzopyranyl Isoxazolines: Cycloaddition Reaction of Chromone Nitrile Oxide

Heterocycles ◽  
1988 ◽  
Vol 27 (5) ◽  
pp. 1127 ◽  
Author(s):  
Jagir Singh Sandhu ◽  
Arpan K. Baruah ◽  
Dipan Prajapati ◽  
Jagir S. Sandhu
Keyword(s):  
Cycloaddition Reaction ◽  
Nitrile Oxide ◽  
Novel Synthesis

New Strategy of Synthesis of Peramivir Analogues as Potential Neuraminidase Inhibitors

Synthesis ◽  
2019 ◽  
Vol 52 (06) ◽  
pp. 933-941
Author(s):  
Roberta Bartolotta ◽  
Concetta La Rosa ◽  
Donatella Nava
Keyword(s):  
Cycloaddition Reaction ◽  
Nitrile Oxide ◽  
Hydroxyl Group ◽  
Dipolar Cycloaddition ◽  
Carbon Nucleus ◽  
Neuraminidase Inhibitors ◽  
Subsequent Reaction ◽  
New Strategy

Highly functionalised potential neuraminidase (NA) inhibitors, analogues of peramivir, were synthesised via a new and versatile method starting from a stereoselective 1,3-dipolar cycloaddition reaction between the nitrile oxide derived from 2-ethylbutanal and the commercially available and inexpensive cyclopentadiene and 1,3-cyclohexadiene, which afforded the isoxazolino-cyclopentene or cyclohexene intermediates, respectively. The subsequent reaction of the C=C bond in different conditions allowed the functionalisation of the five (or six) membered carbon nucleus. Further functionalised derivatives displaying an amino and a hydroxyl group were achieved via the final opening of the isoxazoline ring.

Novel Trinitrogen-Containing Triheterocycles via the Intramolecular Nitrile Oxide Cycloaddition Reaction

Synthesis ◽  
2011 ◽  
Vol 2011 (20) ◽  
pp. 3241-3246
Author(s):  
Mark Kurth ◽  
Andrew Ferreira ◽  
Danielle Solano ◽  
James Oakdale
Keyword(s):  
Cycloaddition Reaction ◽  
Nitrile Oxide

Furanoterpene Synthesis via Intramolecular Nitrile Oxide Cycloaddition Reaction: A Total Synthesis of (+)-Menthofuran

Heterocycles ◽  
1993 ◽  
Vol 36 (2) ◽  
pp. 345 ◽  
Author(s):  
Kozo Shishido ◽  
Koji Umimoto ◽  
Takeshi Takata ◽  
Osamu Irie ◽  
Masayuki Shibuya
Keyword(s):  
Total Synthesis ◽  
Cycloaddition Reaction ◽  
Nitrile Oxide

Investigating the reaction pathways of chemical functionalization of C20 fullerene by nitrile oxide and azide; A computational study

2018 ◽  
Vol 17 (01) ◽  
pp. 1850003
Author(s):  
Sakineh Asghari ◽  
Ali Asghar Gouran ◽  
Davood Farmanzadeh ◽  
Tahereh Abdollahi
Keyword(s):  
Functional Group ◽  
Computational Study ◽  
Cycloaddition Reaction ◽  
Nitrile Oxide ◽  
Dipolar Cycloaddition ◽  
Hydrazoic Acid ◽  
Density Of State ◽  
Electronic Density ◽  
C20 Fullerene ◽  
Oxide Group

In this study, the interactions between nitrile oxide (fulminic acid) and azide (hydrazoic acid) with the C[Formula: see text] fullerene were investigated and their priority in reacting and functionalizing surface of this fullerene were compared with each other. The results show that the 1,3-dipolar cycloaddition reaction between fulminic acid and C[Formula: see text] fullerene could occur faster than this reaction by hydrazoic acid. Therefore, nitrile oxide group as a dipole is much preferred compared to the azide functional group in reacting with the surface of C[Formula: see text] fullerene. In addition, the calculated adsorption energy and electronic density of state, DOS plots for the related species confirmed that the C[Formula: see text] fullerene can be used as sensors for sensing the hydrazoic acid and fulminic acid molecules.

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