ChemInform Abstract: Calcium Carbide as a Cost-Effective Starting Material for Symmetrical Diarylethynes via Pd-Catalyzed Coupling Reaction.

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Padon Chuentragool ◽  
Kunnigar Vongnam ◽  
Paitoon Rashatasakhon ◽  
Mongkol Sukwattanasinitt ◽  
Sumrit Wacharasindhu
Keyword(s):  
Coupling Reaction ◽  
Calcium Carbide ◽  
Cost Effective ◽  
Starting Material

Calcium carbide as a cost-effective starting material for symmetrical diarylethynes via Pd-catalyzed coupling reaction

Tetrahedron ◽  
2011 ◽  
Vol 67 (42) ◽  
pp. 8177-8182 ◽  
Author(s):  
Padon Chuentragool ◽  
Kunnigar Vongnam ◽  
Paitoon Rashatasakhon ◽  
Mongkol Sukwattanasinitt ◽  
Sumrit Wacharasindhu
Keyword(s):  
Coupling Reaction ◽  
Calcium Carbide ◽  
Cost Effective ◽  
Starting Material

scholarly journals Grignard coupling-based synthesis of vinyl-substituted hydridopolycarbosilane: effect of starting material and polymerization behavior

RSC Advances ◽  
2021 ◽  
Vol 11 (19) ◽  
pp. 11771-11778
Author(s):  
Minji Jeong ◽  
Moon-Gun Choi ◽  
Yoonjoo Lee
Keyword(s):  
Coupling Reaction ◽  
Starting Material ◽  
Polymerization Behavior

Polymerization of VHPCS by the Grignard coupling reaction depended on the type of starting material. In the case of Cl3SiCH2Cl starting material, a stepwise growth manner was shown, due to a coupling between –CH2Cl and the Si–Cl sites.

The Preparation of 1,2-Bis(2,2′:6′,2′′-Terpyridin-4′yl)Ethanone: The First Example of 4′-Terpyridyls Unsymmetrically Linked by a Functionalized Two-Carbon Chain

2004 ◽  
Vol 57 (7) ◽  
pp. 689 ◽  
Author(s):  
Zhi-Long Chen ◽  
Ronald N. Warrener ◽  
Douglas N. Butler
Keyword(s):  
Sulfuric Acid ◽  
Hydrochloric Acid ◽  
Single Crystal ◽  
Coupling Reaction ◽  
Carbon Chain ◽  
Sodium Cyanide ◽  
Starting Material ◽  
X Ray ◽  
Concentrated Sulfuric Acid ◽  
Single Crystal Analysis

1,2-Bis(2,2′:6′,2′′-terpyridin-4′yl)ethanone 7, an unsymmetrically linked bis-tridentatate ligand, was prepared by treatment of 4′-cyanomethylterpyridine 10 (RT, overnight) or 4′-(methoxycarbonylmethyl)terpyridine 11 (60°C, 7 h) with concentrated hydrochloric acid. These conversions, which involved an unprecedented homo-coupling reaction, are discussed with the structure of 7 being confirmed by X-ray single crystal analysis. The nitrile starting material 10 was prepared by reaction of the mesylate 9, derived from the known 4′-hydroxymethylterpyridine 8 with sodium cyanide, while ester 11 was prepared by reaction of 10 with methanol in the presence of concentrated sulfuric acid.

scholarly journals Spent Yeast from Brewing Processes: A Biodiverse Starting Material for Yeast Extract Production

Fermentation ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. 51 ◽  
Author(s):  
Friedrich Felix Jacob ◽  
Lisa Striegel ◽  
Michael Rychlik ◽  
Mathias Hutzler ◽  
Frank-Jürgen Methner
Keyword(s):  
Yeast Extract ◽  
Cost Effective ◽  
Lactobacillus Brevis ◽  
Fermentation Medium ◽  
Starting Material ◽  
Industrial Manufacturing ◽  
Yeast Strains ◽  
Brewing Process ◽  
P 16 ◽  
Saccharomyces Yeast

Spent yeast from beer manufacturing is a cost-effective and nutrient-rich starting material for the production of yeast extracts. In this study, it is shown how physiologically important ingredients in a yeast extract are influenced by the composition of the spent yeast from the brewing process. In pilot fermentations, the time of cropping (primary fermentation, lagering) of the spent yeast and the original gravity (12 ˚P, 16 ˚P, 20 ˚P) of the fermentation medium was varied, and four alternative non-Saccharomyces yeast strains were compared with two commercial Saccharomyces yeast strains. In addition, spent yeast was contaminated with the beer spoiler Lactobacillus brevis. The general nutrient composition (total protein, fat, ash) was investigated as well as the proteinogenic amino acid spectrum, the various folate vitamers (5-CH3-H4folate, 5-CHO-H4folate, 10-CHO-PteGlu, H4folate, PteGlu) and the biological activity (reduction, antioxidative potential) of a mechanically (ultrasonic sonotrode) and an autolytically produced yeast extract. All the investigated ingredients from the yeast extract were influenced by the composition of the spent yeast from the brewing process. The biodiversity of the spent yeast from the brewing process therefore directly affects the content of physiologically valuable ingredients of a yeast extract and should be taken into consideration in industrial manufacturing processes.

Synthesis of 6-alkynylated uridines

1986 ◽  
Vol 64 (8) ◽  
pp. 1560-1563 ◽  
Author(s):  
Hiromichi Tanaka ◽  
Kazuhiro Haraguchi ◽  
Yachiyo Koizumi ◽  
Mariko Fukui ◽  
Tadashi Miyasaka
Keyword(s):  
Coupling Reaction ◽  
Starting Material ◽  
Terminal Alkynes

6-Alkynylated uridines, a hitherto unknown class of compounds, were synthesized by a coupling reaction of terminal alkynes with 6-iodo-2′,3′-O-isopropylidene-5′-O-methoxymethyluridine in the presence of bis(triphenylphosphine)palladium(II) chloride and copper(I) iodide. 6-Ethynyl-2′-deoxyuridine was also prepared by using 6-iodo-3′,5′-O-(tetraisopropyldisiloxan-1,3-diyl)-2′-deoxyuridine as a starting material.

scholarly journals Hollow-Shell-Structured Mesoporous Silica-Supported Palladium Catalyst for an Efficient Suzuki-Miyaura Cross-Coupling Reaction

Catalysts ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 582
Author(s):  
Abdulelah Taher Ali Mohammed ◽  
Lijian Wang ◽  
Ronghua Jin ◽  
Guohua Liu ◽  
Chunxia Tan
Keyword(s):  
Chemical Engineering ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Cost Effective ◽  
Active Species ◽  
Palladium Acetate ◽  
Hollow Shell ◽  
Electron Microscopies ◽  
Cross Coupling Reaction ◽  
The Cost

The construction of a high stability heterogeneous catalyst for privileged common catalysis is a benefit in regard to reuse and separation. Herein, a palladium diphenylphosphine-based hollow-shell-structured mesoporous catalyst (HS@PdPPh2@MSN) was prepared by immobilizing bis((diphenylphosphino)ethyltriethoxysilane)palladium acetate onto the inner wall of a mesoporous organicsilicane hollow shell, whose surface was protected by a –Si(Me)3 group. Electron microscopies confirmed its hollow-shell-structure, and structural analyses and characterizations revealed its well-defined single-site active species within the silicate network. As presented in this study, the newly constructed HS@PdPPh2@MSN enabled an efficient Suzuki-Miyaura cross-coupling reaction for varieties of substrates with up to 95% yield in mild conditions. Meanwhile, it could be reused at least five times with good activity, indicating its excellent stability and recyclability. Furthermore, the cost-effective and easily synthesized HS@PdPPh2@MSN made it a good candidate for employment in fine chemical engineering.

Anchored Pd(0) Nanoparticles on Synthetic Talc for the Synthesis of Biaryls and a Precursor of Angiotensin II Inhibitors

Synthesis ◽  
2020 ◽  
Author(s):  
Nelson Luís C. Domingues ◽  
Beatriz F. dos Santos ◽  
Beatriz A. L. da Silva ◽  
Aline R. de Oliveira ◽  
Maria H. Sarragiotto
Keyword(s):  
Angiotensin Ii ◽  
Palladium Catalysts ◽  
Rational Design ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Cost Effective ◽  
Significant Loss ◽  
Cross Coupling Reaction ◽  
Palladium Catalyzed ◽  
Short Time

AbstractThe palladium-catalyzed Suzuki–Miyaura cross-coupling reaction is one of the most important and efficient reactions to prepare a variety of organic compounds, including biaryls. Despite the overwhelming number of reports related to this topic, some methodological difficulties persist in terms of catalyst handling, recovery, and reuse, as well as the reaction media. This work reports the rational design of new, efficient, cost-effective, and reusable palladium catalysts supported on synthetic talc for the Suzuki–Miyaura reaction. From the results, key points were identified: both designed catalysts accelerated the reaction in EtOH and an open-flask setup, affording moderate to excellent yields within a short time (e.g., 30 min) even for deactivated aryl halides; the protocol can be applied to a great number of both cross-coupling partners, showing an excellent functional group tolerance; the catalysts can be recovered and reused without significant loss of activity. This protocol was used for the synthesis of a precursor of angiotensin II inhibitors such as valsartan, losartan, irbesartan, and telmisartan.

scholarly journals Cost-Effective Cosmetic-Grade Hyaluronan Hydrogels for ReNcell VM Human Neural Stem Cell Culture

Biomolecules ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 515 ◽  
Author(s):  
Ma ◽  
Suh
Keyword(s):  
Stem Cell ◽  
Neuronal Differentiation ◽  
Neural Stem Cell ◽  
Pharmaceutical Research ◽  
Cost Effective ◽  
Cellular Adhesion ◽  
Starting Material ◽  
Human Neural Stem Cells ◽  
Similar Chemical

Hyaluronic acid (HA) is a polysaccharide polymer frequently used as a starting material to fabricate hydrogels, especially for recapitulating the brain’s extracellular matrix (ECM) for in vitro neural stem cell (NSC) cultures. Here, we report the successful synthesis of a methacrylated HA (MeHA) polymer from an inexpensive cosmetic-grade hyaluronan starting material. The MeHA polymers synthesized from cosmetic-grade HA yielded similar chemical purity to those from pharmaceutical/research-grade HA reported in the literature. Crosslinked MeHA (x-MeHA) hydrogels were formed using radical polymerization which resulted in mechanical properties matching previously reported mechanical property ranges for enhanced neuronal differentiation of NSCs. We assessed cellular adhesion, spreading, proliferation, and stiffness-dependent neuronal differentiation properties of ReNcell VM human neural stem cells (hNSCs) and compared our results to studies reported in the literature (that utilized non-human and human pluripotent cell-derived NSCs).

scholarly journals A chiral “Siamese-Twin” calix[4]pyrrole tetramer

2016 ◽  
Vol 7 (9) ◽  
pp. 5976-5982 ◽  
Author(s):  
Albano Galán ◽  
Gemma Aragay ◽  
Pablo Ballester
Keyword(s):  
Coupling Reaction ◽  
Starting Material ◽  
Reaction Conditions ◽  
Siamese Twin

We describe our results in the attempted template syntheses of oligomacrocycle calix[4]pyrrole dimer 4, using Hay coupling reaction conditions, tetraalkynyl calix[4]pyrrole 5 as starting material and two bipyridyl N-oxides of different length as templates.

Nickel nanoparticles supported on reduced graphene oxide sheets: a phosphine free, magnetically recoverable and cost effective catalyst for Sonogashira cross-coupling reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103105-103115 ◽  
Author(s):  
Najrul Hussain ◽  
Pranjal Gogoi ◽  
Puja Khare ◽  
Manash R. Das
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Cost Effective ◽  
Coupling Reactions ◽  
Efficient Catalyst ◽  
Cross Coupling Reactions ◽  
Reduced Graphene ◽  
Graphene Oxide Sheets

Synthesis of magnetically recoverable Ni nanoparticles supported reduced graphene oxide sheets as an efficient catalyst for the Sonogashira cross-coupling reaction.

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