ChemInform Abstract: A Bioinspired Ugi/Michael/Aza-Michael Cascade Reaction in Aqueous Media: Natural-Product-Like Molecular Diversity.

ChemInform ◽  
2012 ◽  
Vol 43 (8) ◽  
pp. no-no
Author(s):  
Soumava Santra ◽  
Peter R. Andreana
Keyword(s):  
Natural Product ◽  
Molecular Diversity ◽  
Aqueous Media ◽  
Cascade Reaction

scholarly journals Molecular diversity of bacteria in commercially available “Spirulina” food supplements

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e1610 ◽  
Author(s):  
Elisabeth Vardaka ◽  
Konstantinos A. Kormas ◽  
Matina Katsiapi ◽  
Savvas Genitsaris ◽  
Maria Moustaka-Gouni
Keyword(s):  
Natural Product ◽  
454 Pyrosequencing ◽  
Molecular Diversity ◽  
Arthrospira Platensis ◽  
Food Supplements ◽  
Health Issues ◽  
Operational Taxonomic Units ◽  
Health Promoting ◽  
First Time ◽  
Pyrosequencing Analysis

The cyanobacteriumArthrospirais among the most well-known food supplements worldwide known as “Spirulina.” While it is a widely recognized health-promoting natural product, there are no reports on the molecular diversity of commercially available brands of “Spirulina” supplements and the occurrence of other cyanobacterial and heterotrophic bacterial microorganisms in these products. In this study, 454-pyrosequencing analysis of the total bacterial occurrence in 31 brands of “Spirulina” dietary supplements from the Greek market was applied for the first time. In all samples, operational taxonomic units (OTUs) ofArthrospira platensiswere the predominant cyanobacteria. Some products contained additional cyanobacterial OTUs including a few known potentially toxic taxa. Moreover, 469 OTUs were detected in all 31 products collectively, with most of them being related to the Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Verrucomicrobia. All samples included heterotrophic bacterial OTUs, ranging from 9–157 per product. Among the most common OTUs were ones closely related to taxa known for causing health issues (i.e.,Pseudomonas,Flavobacterium,Vibrio,Aeromonas,Clostridium,Bacillus,Fusobacterium,Enterococcus). The observed high cyanobacterial and heterotrophic bacterial OTUs richness in the final product is a point for further research on the growth and processing ofArthrospirabiomass for commercial purposes.

A bifunctional pyrazolone–chromone synthon directed organocatalytic double Michael cascade reaction: forging five stereocenters in structurally diverse hexahydroxanthones

2019 ◽  
Vol 6 (9) ◽  
pp. 1485-1490 ◽  
Author(s):  
Xiong-Li Liu ◽  
Xiong Zuo ◽  
Jun-Xin Wang ◽  
Shun-qin Chang ◽  
Qi-Di Wei ◽  
...  
Keyword(s):  
Small Molecules ◽  
Natural Product ◽  
Cascade Reaction

The merging of two or more known natural product-based scaffolds is a powerful and routine strategy to develop bioactive small molecules.

scholarly journals Synthesis of Functionalized Dihydropyrido[2,3-d]pyrimidines in Aqueous Medium

SynOpen ◽  
2018 ◽  
Vol 02 (01) ◽  
pp. 0001-0005 ◽  
Author(s):  
Saeed Balalaie ◽  
Hamed Esmaeilabadi ◽  
Saber Mehrparvar ◽  
Frank Rominger ◽  
Fatima Hamdan ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Aqueous Media ◽  
Aromatic Aldehydes ◽  
Cascade Reaction ◽  
Hydrogen Phosphate ◽  
Diammonium Hydrogen Phosphate ◽  
Diammonium Hydrogen

Synthesis of functionalized 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one from a cascade reaction between 3-formylchromone, malononitrile, diammonium hydrogen phosphate, and aromatic aldehydes in aqueous media is described.

One-pot synthesis of natural-product inspired spiroindolines with anti-cancer activities

2022 ◽  
Author(s):  
Shiqiang Li ◽  
Wei Yan ◽  
Liu-Jun He ◽  
Ming Zhang ◽  
Dianyong Tang ◽  
...  
Keyword(s):  
Natural Product ◽  
Cascade Reaction ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Anti Cancer

A post-Ugi/diastereoselective cascade reaction was developed to construct naturally existing spiroindolines via a facile and metal-free one-pot protocol. During the construction, a new C-C bond was formed through a selective...

The metal tin promoted cascade reaction of ketones in aqueous media for the construction of 2-bromo-4-aryl-1,3-pentadiene

2014 ◽  
Vol 12 (29) ◽  
pp. 5393-5399 ◽  
Author(s):  
Lingyan Liu ◽  
Yan Zhang ◽  
Hua Zhang ◽  
Kaimeng Huang ◽  
Bo-xin Gao ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Aqueous Media ◽  
Cascade Reaction

A novel Barbier-type allenylation cascade reaction of carbonyl compounds promoted by tin was discovered, and afforded a new, highly functionalized 1,3-pentadiene.

ChemInform Abstract: The Metal Tin Promoted Cascade Reaction of Ketones in Aqueous Media for the Construction of 2-Bromo-4-aryl-1,3-pentadiene.

ChemInform ◽  
2015 ◽  
Vol 46 (1) ◽  
Author(s):  
Lingyan Liu ◽  
Yan Zhang ◽  
Hua Zhang ◽  
Kaimeng Huang ◽  
Bo-xin Gao ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Cascade Reaction

scholarly journals 3-Bromotetrazine: A Versatile Precursor for the Synthesis of 3-Monosubstituted s-Tetrazines and the Labelling of Macromolecules

2019 ◽  
Author(s):  
Simon Schnell ◽  
Lukas Hoff ◽  
Advaita Panchagnula ◽  
Simon Sieber ◽  
Anthony Linden ◽  
...  
Keyword(s):  
Natural Product ◽  
Mammalian Cells ◽  
Functional Group ◽  
Aqueous Media ◽  
Diels Alder ◽  
The Novel ◽  
Chemical Probe ◽  
Complex Molecules ◽  
Inverse Electron Demand ◽  
Electron Demand

<div><div><div><p>We report the synthesis of the novel precursor 3-bromotetrazine and its successful use in the synthesis of various families of 3-monosubstituted s-tetrazines. A remarkable functional group selectivity is utilized to site-selectively functionalize different complex molecules. The unexpected stability of 3- bromotetrazine in aqueous media facilitated the development of a protocol for protein functionalization in- stalling a tetrazine unit as a bio-orthogonal handle for inverse electron demand Diels-Alder reactions. Addi- tionally, a novel tetrazine-based chemical probe was developed and its application in the context of thiol- targeted natural product isolation and labelling of mammalian cells is demonstrated.</p></div></div></div>

An Efficient Solvent- and Catalyst-Free Synthesis of Bicyclic Pyridones with High Molecular Diversity via Cascade Reaction

Heterocycles ◽  
2018 ◽  
Vol 96 (2) ◽  
pp. 311 ◽  
Author(s):  
Chao Huang ◽  
Wen-Rong Yang ◽  
Huang-Mei Fu ◽  
Hong-Bin Wang ◽  
Li-Juan Yang
Keyword(s):  
Molecular Diversity ◽  
Cascade Reaction ◽  
Catalyst Free
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