ChemInform Abstract: Microwave-Promoted TBAF-Catalyzed SNAr Reaction of Aryl Fluorides and ArSTMS: An Efficient Synthesis of Unsymmetrical Diaryl Thioethers.

ChemInform ◽  
2011 ◽  
Vol 42 (37) ◽  
pp. no-no
Author(s):  
Chuanzhi Liu ◽  
Xufeng Zang ◽  
Baohua Yu ◽  
Xiaochun Yu ◽  
Qing Xu
Keyword(s):  
Efficient Synthesis ◽  
Snar Reaction

scholarly journals Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated SNAr reaction

2011 ◽  
Vol 7 ◽  
pp. 1360-1371 ◽  
Author(s):  
Charlotte Wiles ◽  
Paul Watts
Keyword(s):  
Reaction Time ◽  
Continuous Flow ◽  
Stopped Flow ◽  
Efficient Synthesis ◽  
Diaryl Ethers ◽  
Microwave Reactor ◽  
Starting Point ◽  
Microreaction Technology ◽  
Snar Reaction ◽  
Rapid Reaction

Whilst microwave heating has been widely demonstrated as a synthetically useful tool for rapid reaction screening, a microwave-absorbing solvent is often required in order to achieve efficient reactant heating. In comparison, microreactors can be readily heated and pressurised in order to “super-heat” the reaction mixture, meaning that microwave-transparent solvents can also be employed. To demonstrate the advantages associated with microreaction technology a series of SNAr reactions were performed under continuous flow by following previously developed microwave protocols as a starting point for the investigation. By this approach, an automated microreaction platform (Labtrix® S1) was employed for the continuous flow synthesis of diaryl ethers at 195 °C and 25 bar, affording a reduction in reaction time from tens of minutes to 60 s when compared with a stopped-flow microwave reactor.

scholarly journals Improved Synthesis of Phosphoramidite-Protected N6-Methyladenosine via BOP-Mediated SNAr Reaction

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 147
Author(s):  
Shifali Shishodia ◽  
Christopher J. Schofield
Keyword(s):  
Anticancer Drug ◽  
Dna Adduct ◽  
Efficient Synthesis ◽  
Snar Reaction ◽  
Adenosine Derivatives

N6-methyladenosine(m6A) is the most abundant modification in mRNA. Studies on proteins that introduce and bind m6A require the efficient synthesis of oligonucleotides containing m6A. We report an improved five-step synthesis of the m6A phosphoramidite starting from inosine, utilising a 1-H-benzotriazol-1-yloxytris(dimethylamino)phosphoniumhexafluorophosphate (BOP)-mediated SNAr reaction in the key step. The route manifests a substantial increase in overall yield compared to reported routes, and is useful for the synthesis of phosphoramidites of other adenosine derivatives, such as ethanoadenosine, an RNA analogue of the DNA adduct formed by the important anticancer drug Carmustine.

Microwave-Promoted TBAF-Catalyzed SNAr Reaction of Aryl Fluorides and ArSTMS: An Efficient Synthesis of Unsymmetrical Diaryl Thioethers

Synlett ◽  
2011 ◽  
Vol 2011 (08) ◽  
pp. 1143-1148 ◽  
Author(s):  
Xiaochun Yu ◽  
Qing Xu ◽  
Chuanzhi Liu ◽  
Xufeng Zang ◽  
Baohua Yu
Keyword(s):  
Efficient Synthesis ◽  
Snar Reaction

A new facile and efficient synthesis of trans-(+)-sobrerol by biotransformation of α-pinene using extremophiles microorganisms

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
LA Vilaseca ◽  
J Quillaguamán ◽  
L Fuentes ◽  
O Sterner
Keyword(s):  
Efficient Synthesis

Highly efficient synthesis of methyl ethyl ketone oxime through ammoximation over Ti-MOR catalyst

2014 ◽  
Vol 34 (1) ◽  
pp. 243-250
Author(s):  
Jianghong DING ◽  
Le XU ◽  
Hao XU ◽  
Haihong WU ◽  
Yueming LIU ◽  
...  
Keyword(s):  
Methyl Ethyl Ketone ◽  
Methyl Ethyl ◽  
Efficient Synthesis ◽  
Highly Efficient

Advanced Heterocyclic Branched Semiconducting Units - Highly Efficient Synthesis and Physicochemical Characteristic

2013 ◽  
Vol 17 (3) ◽  
pp. 283-295 ◽  
Author(s):  
Jadwiga Soloducho ◽  
Joanna Cabaj ◽  
Kamila Olech ◽  
Przemyslaw Data ◽  
Mieczyslaw Lapkowski
Keyword(s):  
Physicochemical Characteristic ◽  
Efficient Synthesis ◽  
Highly Efficient

Facile and Efficient Synthesis of New Class of Imidazole Derivatives via One-Pot Multicomponent Reactions in Water

2013 ◽  
Vol 16 (10) ◽  
pp. 788-790
Author(s):  
Zinatossadat Hossaini ◽  
Samereh Seyfi ◽  
Faramarz Rostami-Charati ◽  
Mehdi Ghambarian
Keyword(s):  
Multicomponent Reactions ◽  
Efficient Synthesis ◽  
One Pot ◽  
Imidazole Derivatives ◽  
New Class
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