ChemInform Abstract: From Polymer to Small Organic Molecules: A Tight Relationship Between Radical Chemistry and Solid-Phase Organic Synthesis

ChemInform ◽  
2011 ◽  
Vol 42 (36) ◽  
pp. no-no
Author(s):  
Danilo Mirizzi ◽  
Maurizio Pulici
Keyword(s):  
Organic Synthesis ◽  
Organic Molecules ◽  
Solid Phase ◽  
Small Organic Molecules ◽  
Radical Chemistry ◽  
Solid Phase Organic Synthesis

Greener solvents for solid-phase organic synthesis

2018 ◽  
Vol 90 (1) ◽  
pp. 157-165 ◽  
Author(s):  
Stefan B. Lawrenson
Keyword(s):  
Organic Synthesis ◽  
Chemical Process ◽  
Organic Molecules ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Rapid Synthesis ◽  
Small Organic Molecules ◽  
Solid Phase Organic Synthesis ◽  
Reaction Media ◽  
By Products

AbstractSolid-phase organic synthesis is an essential method for the rapid synthesis of complex biological structures and libraries of small organic molecules. However, it is often associated with the use of large quantities of problematic solvents for the removal of excess reagents and reaction by-products. Given that solvent will often be the biggest contributor to waste generated in the average pharmaceutical/fine-chemical process, its exchange for a more desirable alternative often presents the biggest gains in terms of reducing environmental impact. This review aims to explore recent approaches to performing solid-phase organic synthesis, and associated solid-phase peptide synthesis, in neoteric solvents and reaction media that present greener alternatives.

Recent Application of Polystyrene-supported Triphenylphosphine in Solid-Phase Organic Synthesis

2019 ◽  
Vol 23 (6) ◽  
pp. 643-678
Author(s):  
Lalthazuala Rokhum ◽  
Ghanashyam Bez
Keyword(s):  
Organic Synthesis ◽  
Combinatorial Chemistry ◽  
Solid Phase ◽  
Recent Application ◽  
Organic Transformations ◽  
Solid Phase Organic Synthesis ◽  
Wide Range ◽  
Fast Development ◽  
Polymer Supported

Recent years have witnessed a fast development of solid phase synthetic pathways, a variety of solid-supported reagent and its applications in diverse synthetic strategies and pharmaceutical applicability’s. Polymer-supported triphenylphosphine is getting a lot of applications owing to the speed and simplicity in the process. Furthermore, ease of recyclability and reuse of polymer-supported triphenylphosphine added its advantages. This review covers a wide range of useful organic transformations which are accomplished using cross-linked polystyrene-supported triphenylphosphine with the aim of giving renewed interest in the field of organic and medicinal-combinatorial chemistry.

Neutral Reducing Agents Supported on Merrifield Resin Obtained by Solid Phase Organic Synthesis

Tetrahedron ◽  
2021 ◽  
pp. 132195
Author(s):  
Milagros Aguilar-Martínez ◽  
Judas Tadeo Vargas-Durazo ◽  
Adrián Ochoa-Terán ◽  
Hisila Santacruz-Ortega ◽  
Karen Ochoa Lara ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Reducing Agents ◽  
Solid Phase Organic Synthesis ◽  
Merrifield Resin

PhFl acetic acid: A new linker for solid phase organic synthesis

1998 ◽  
Vol 39 (26) ◽  
pp. 4591-4594 ◽  
Author(s):  
Konrad H. Bleicher ◽  
James R. Wareing
Keyword(s):  
Acetic Acid ◽  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis

Solid Phase Organic Synthesis of Piperazinone Containing Enkephalin Mimetics:  A Readily Derivatized, Traceless Scaffold

1999 ◽  
Vol 1 (5) ◽  
pp. 383-387 ◽  
Author(s):  
Kevin Shreder ◽  
Li Zhang ◽  
Jean-Paul Gleeson ◽  
Jens A. Ericsson ◽  
Venkatachalapathi V. Yalamoori ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis

PhFl polystyrene: A new resin for solid phase organic synthesis

1998 ◽  
Vol 39 (26) ◽  
pp. 4587-4590 ◽  
Author(s):  
Konrad H. Bleicher ◽  
James R. Wareing
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis

Perkin 1 Abstracts: Solid Phase Organic Synthesis

1999 ◽  
pp. xi-xiv
Author(s):  
John Christopher ◽  
Catherine McCusker ◽  
Susan Booth ◽  
Jason Tierney
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis
Sign in / Sign up

Export Citation Format

Share Document